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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p21.2
Chromosome location (bp)
27109141 - 27230174
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital malformations Congenital malformations of eye Congenital malformations of the circulatory system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0001935[endothelial cell proliferation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002040[sprouting angiogenesis] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0005902[microvillus] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007267[cell-cell signaling] GO:0007507[heart development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010595[positive regulation of endothelial cell migration] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016525[negative regulation of angiogenesis] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030334[regulation of cell migration] GO:0032878[regulation of establishment or maintenance of cell polarity] GO:0033674[positive regulation of kinase activity] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034451[centriolar satellite] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043114[regulation of vascular permeability] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045121[membrane raft] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0048014[Tie signaling pathway] GO:0050728[negative regulation of inflammatory response] GO:0051894[positive regulation of focal adhesion assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0060216[definitive hemopoiesis] GO:0060347[heart trabecula formation] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072012[glomerulus vasculature development] GO:0072359[circulatory system development] GO:1902533[positive regulation of intracellular signal transduction] GO:2000026[regulation of multicellular organismal development] GO:2000251[positive regulation of actin cytoskeleton reorganization] GO:2000351[regulation of endothelial cell apoptotic process] GO:2000352[negative regulation of endothelial cell apoptotic process]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital malformations Congenital malformations of eye Congenital malformations of the circulatory system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0001935[endothelial cell proliferation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002040[sprouting angiogenesis] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0005902[microvillus] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007267[cell-cell signaling] GO:0007507[heart development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010595[positive regulation of endothelial cell migration] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016525[negative regulation of angiogenesis] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030334[regulation of cell migration] GO:0032878[regulation of establishment or maintenance of cell polarity] GO:0033674[positive regulation of kinase activity] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034451[centriolar satellite] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043114[regulation of vascular permeability] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045121[membrane raft] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0048014[Tie signaling pathway] GO:0050728[negative regulation of inflammatory response] GO:0051894[positive regulation of focal adhesion assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0060216[definitive hemopoiesis] GO:0060347[heart trabecula formation] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072012[glomerulus vasculature development] GO:0072359[circulatory system development] GO:1902533[positive regulation of intracellular signal transduction] GO:2000026[regulation of multicellular organismal development] GO:2000251[positive regulation of actin cytoskeleton reorganization] GO:2000351[regulation of endothelial cell apoptotic process] GO:2000352[negative regulation of endothelial cell apoptotic process]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of eye Congenital malformations of the circulatory system Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0030334[regulation of cell migration] GO:0072359[circulatory system development] GO:2000026[regulation of multicellular organismal development]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital malformations Congenital malformations of eye Congenital malformations of the circulatory system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0001935[endothelial cell proliferation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002040[sprouting angiogenesis] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0005911[cell-cell junction] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007267[cell-cell signaling] GO:0007507[heart development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010595[positive regulation of endothelial cell migration] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016525[negative regulation of angiogenesis] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030334[regulation of cell migration] GO:0032878[regulation of establishment or maintenance of cell polarity] GO:0033674[positive regulation of kinase activity] GO:0034446[substrate adhesion-dependent cell spreading] GO:0034451[centriolar satellite] GO:0038023[signaling receptor activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043114[regulation of vascular permeability] GO:0043235[receptor complex] GO:0043410[positive regulation of MAPK cascade] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045121[membrane raft] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0048014[Tie signaling pathway] GO:0050728[negative regulation of inflammatory response] GO:0051894[positive regulation of focal adhesion assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0060216[definitive hemopoiesis] GO:0060347[heart trabecula formation] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072012[glomerulus vasculature development] GO:0072359[circulatory system development] GO:1902533[positive regulation of intracellular signal transduction] GO:2000026[regulation of multicellular organismal development] GO:2000251[positive regulation of actin cytoskeleton reorganization] GO:2000351[regulation of endothelial cell apoptotic process] GO:2000352[negative regulation of endothelial cell apoptotic process]
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Human disease related genes Congenital malformations Congenital malformations of eye Congenital malformations of the circulatory system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005524[ATP binding] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0072359[circulatory system development]
The Human Protein Atlas project is funded
