GENERAL INFORMATIONi
Gene namei PTK2
Synonyms FADK, FAK, FAK1, PPP1R71
Gene descriptioni Protein tyrosine kinase 2
Protein classi Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 8
Cytoband q24.3
Chromosome location (bp) 140657900 - 141002216
Number of transcriptsi 34
Ensembl ENSG00000169398 (version 109)
Entrez gene 5747
HGNC HGNC:9611
UniProt Q05397 (UniProt - Evidence at protein level)
neXtProt NX_Q05397
GeneCards PTK2
Antibodypedia PTK2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation 1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. show less
Molecular function (UniProt)i Developmental protein, Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Angiogenesis
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PTK2-201
ENSP00000341189
ENST00000340930
Q05397
[Direct mapping] Focal adhesion kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035995 [detection of muscle stretch]
GO:0036064 [ciliary basal body]
GO:0038007 [netrin-activated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048870 [cell motility]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
GO:0090303 [positive regulation of wound healing]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140677 [molecular function activator activity]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1065 aa
120.9 kDa 		No 0
PTK2-202
ENSP00000378644
ENST00000395218
Q05397
[Direct mapping] Focal adhesion kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035995 [detection of muscle stretch]
GO:0036064 [ciliary basal body]
GO:0038007 [netrin-activated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048870 [cell motility]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
GO:0090303 [positive regulation of wound healing]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140677 [molecular function activator activity]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1006 aa
114.3 kDa 		No 0
PTK2-203
ENSP00000403416
ENST00000430260
B4DWJ1
[Direct mapping] Focal adhesion kinase 1; cDNA FLJ57218, highly similar to Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 362 aa
40.2 kDa 		No 0
PTK2-205
ENSP00000430951
ENST00000517453
E5RH01
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 117 aa
13.2 kDa 		No 0
PTK2-206
ENSP00000430916
ENST00000517712
E5RHD8
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 115 aa
12.9 kDa 		No 0
PTK2-207
ENSP00000429082
ENST00000517887
E7ESA6
[Direct mapping] Non-specific protein-tyrosine kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0008284 [positive regulation of cell population proliferation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
Show all
 1096 aa
124.1 kDa 		No 0
PTK2-210
ENSP00000428232
ENST00000519024
E5RJI4
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 168 aa
19.2 kDa 		No 0
PTK2-212
ENSP00000429129
ENST00000519419
E7ESA6
[Direct mapping] Non-specific protein-tyrosine kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0008284 [positive regulation of cell population proliferation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
Show all
 1096 aa
124.1 kDa 		No 0
PTK2-213
ENSP00000429170
ENST00000519465
E9PEI4
[Direct mapping] Focal adhesion kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 680 aa
76.8 kDa 		No 0
PTK2-215
ENSP00000429929
ENST00000519654
H0YBP1
[Direct mapping] Non-specific protein-tyrosine kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0008284 [positive regulation of cell population proliferation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
Show all
 1017 aa
115.4 kDa 		No 0
PTK2-216
ENSP00000430277
ENST00000519881
E5RFW9
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 121 aa
13.8 kDa 		No 0
PTK2-219
ENSP00000430044
ENST00000520045
E5RH01
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 117 aa
13.2 kDa 		No 0
PTK2-220
ENSP00000428482
ENST00000520151
E5RI29
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 124 aa
14 kDa 		No 0
PTK2-222
ENSP00000428792
ENST00000520475
E5RGA6
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
Show all
 156 aa
18.2 kDa 		No 0
PTK2-223
ENSP00000427762
ENST00000520828
E5RG86
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
Show all
 59 aa
7.2 kDa 		No 0
PTK2-225
ENSP00000427904
ENST00000520892
E5RFW9
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 121 aa
13.8 kDa 		No 0
PTK2-228
ENSP00000429474
ENST00000521059
Q05397
[Direct mapping] Focal adhesion kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035995 [detection of muscle stretch]
GO:0036064 [ciliary basal body]
GO:0038007 [netrin-activated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048870 [cell motility]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
GO:0090303 [positive regulation of wound healing]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140677 [molecular function activator activity]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1052 aa
119.2 kDa 		No 0
PTK2-231
ENSP00000429409
ENST00000521332
E5RIK4
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 65 aa
7.2 kDa 		No 0
PTK2-232
ENSP00000429907
ENST00000521395
E5RH48
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 107 aa
12 kDa 		No 0
PTK2-233
ENSP00000431106
ENST00000521562
E5RJQ2
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 132 aa
14.8 kDa 		No 0
PTK2-235
ENSP00000427795
ENST00000521907
E5RG66
[Direct mapping] Focal adhesion kinase 1
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
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 119 aa
13.5 kDa 		No 0
PTK2-238
ENSP00000430603
ENST00000521986
H0YBZ1
[Direct mapping] Focal adhesion kinase 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 753 aa
84.8 kDa 		No 0
PTK2-239
ENSP00000427774
ENST00000522424
E5RG80
[Direct mapping] Focal adhesion kinase 1
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
15 kDa 		No 0
PTK2-240
ENSP00000429911
ENST00000522684
Q05397
[Direct mapping] Focal adhesion kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035995 [detection of muscle stretch]
GO:0036064 [ciliary basal body]
GO:0038007 [netrin-activated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048870 [cell motility]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070161 [anchoring junction]
GO:0071310 [cellular response to organic substance]
GO:0090303 [positive regulation of wound healing]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140677 [molecular function activator activity]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1052 aa
119.2 kDa 		No 0
PTK2-241
ENSP00000429437
ENST00000522950
E5RII9
[Direct mapping] Focal adhesion kinase 1
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
7.6 kDa 		No 0
PTK2-243
ENSP00000429702
ENST00000523388
E5RHK7
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 67 aa
7.3 kDa 		No 0
PTK2-244
ENSP00000430828
ENST00000523435
E5RI03
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 120 aa
13.7 kDa 		No 0
PTK2-246
ENSP00000428492
ENST00000523539
H0YB16
[Direct mapping] Focal adhesion kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 724 aa
81.5 kDa 		No 0
PTK2-249
ENSP00000429028
ENST00000523679
E5RJN1
[Direct mapping] Focal adhesion kinase 1
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 14 aa
1.5 kDa 		No 0
PTK2-252
ENSP00000429530
ENST00000523803
E5RI72
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 120 aa
13.7 kDa 		No 0
PTK2-254
ENSP00000430037
ENST00000524040
E5RH08
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.6 kDa 		No 0
PTK2-256
ENSP00000431023
ENST00000524257
A0A1D5RMT1
[Direct mapping] Focal adhesion kinase 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 8 aa
0.9 kDa 		No 0
PTK2-257
ENSP00000429001
ENST00000524357
E5RJP0
[Direct mapping] Focal adhesion kinase 1
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 122 aa
13.8 kDa 		No 0
PTK2-258
ENSP00000512868
ENST00000696786
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007172 [signal complex assembly]
Show all
 1096 aa
124.2 kDa 		No 0

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The Human Protein Atlas

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