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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Not detected
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
19.0
nTPM
HPA Brain:
15.3
nTPM
GTEx:
19.0
nTPM
FANTOM5:
3.6
Scaled Tags Per Million
Pig:
10.6
nTPM
Mouse:
2.2
nTPM
HIPPOCAMPUS - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA007164
Antibody HPA008905
Glial cells
Not detected
Not detected
Neuronal cells
Not detected
Not detected
HIPPOCAMPAL FORMATION - HPA Brain RNA-seq
Max nTPM
15.3
Sample id
Sample description
nTPM
Hippocampus nTPM: 14.2
2529
Female, age 94, left hemisphere
20.8
2148
Female, age 91, left hemisphere
16.2
1855
Male, age 76, left hemisphere
13.8
2621
Female, age 67, right hemisphere
13.0
1911
Female, age 85, right hemisphere
11.0
1898
Male, age 80, left hemisphere
10.3
Dentate gyrus nTPM: 13.6
2246
Female, age 85, both hemispheres
15.5
2530
Female, age 94, left hemisphere
14.7
2528
Male, age 74, both hemispheres
14.1
2531
Female, age 67, both hemispheres
13.1
2010
Male, age 76, both hemispheres
12.6
1927
Female, age 91, both hemispheres
11.5
Entorhinal gyrus nTPM: 14.3
2686
Male, age 75, right hemisphere
17.8
2117
Female, age 91, right hemisphere
15.0
1787
Male, age 76, left hemisphere
14.2
2613
Female, age 94, left hemisphere
13.9
1938
Female, age 85, left hemisphere
12.7
2764
Male, age 80, right hemisphere
12.3
Hippocampus, CA1 nTPM: 14.5
2045
Male, age 76, both hemispheres
16.6
2527
Male, age 74, both hemispheres
15.0
2082
Female, age 91, right hemisphere
14.1
2749
Male, age 80, left hemisphere
13.6
1873
Female, age 85, both hemispheres
13.0
Hippocampus, CA2 nTPM: 12.7
2249
Male, age 74, both hemispheres
15.4
1940
Female, age 85, left hemisphere
13.8
1963
Male, age 80, left hemisphere
12.7
2437
Female, age 94, left hemisphere
12.1
2113
Female, age 91, right hemisphere
11.1
1892
Male, age 76, both hemispheres
10.8
Hippocampus, CA3 nTPM: 15.3
2620
Female, age 94, left hemisphere
18.4
2436
Male, age 74, both hemispheres
17.6
2861
Female, age 67, both hemispheres
16.6
2137
Male, age 80, left hemisphere
15.3
1867
Male, age 76, both hemispheres
12.3
1891
Female, age 85, both hemispheres
11.9
Parahippocampal cortex nTPM: 12.4
2622
Female, age 67, right hemisphere
17.1
2692
Male, age 74, both hemispheres
15.0
2245
Female, age 91, both hemispheres
14.7
2018
Male, age 76, both hemispheres
14.2
2693
Female, age 94, both hemispheres
12.1
2532
Female, age 72, left hemisphere
11.9
2250
Female, age 67, right hemisphere
11.1
1933
Female, age 85, both hemispheres
10.5
1850
Male, age 80, both hemispheres
9.0
1990
Female, age 91, right hemisphere
8.9
Perirhinal gyrus nTPM: 10.9
2521
Female, age 94, right hemisphere
12.1
2848
Male, age 76, right hemisphere
11.1
1794
Male, age 80, right hemisphere
10.8
1841
Female, age 85, right hemisphere
10.4
1847
Female, age 91, left hemisphere
10.3
Subiculum nTPM: 14.7
2438
Female, age 94, left hemisphere
17.2
2729
Female, age 91, right hemisphere
16.4
2042
Male, age 76, both hemispheres
15.2
1901
Male, age 80, both hemispheres
13.8
2619
Male, age 74, both hemispheres
13.7
1977
Female, age 85, both hemispheres
11.8
HIPPOCAMPAL FORMATION - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
19.0
GTEx sample id
Sample description
nTPM
Brain - Hippocampus Average nTPM: 19.0
Samples: 197
Max nTPM: 34.3
Min nTPM: 5.9
Std nTPM: 5.2
Median nTPM: 18.5
GTEX-ZF28-0011-R1a-SM-4WWD1
60-69 years, male
34.3
GTEX-1GF9V-0011-R1a-SM-CKZNQ
60-69 years, male
33.7
GTEX-WVLH-0011-R1A-SM-4MVOK
50-59 years, male
32.2
GTEX-1399T-0011-R1b-SM-5DUWN
60-69 years, male
30.8
GTEX-X4XX-0011-R1B-SM-3P622
60-69 years, male
30.3
GTEX-132Q8-0011-R1a-SM-5EGLK
60-69 years, male
29.5
GTEX-13NYS-0011-R1b-SM-5MR55
60-69 years, male
29.0
GTEX-14BIM-0011-R1a-SM-69LQI
60-69 years, female
28.7
GTEX-139T8-0011-R1a-SM-5HL75
60-69 years, male
28.5
GTEX-13NYB-0011-R1b-SM-5KM4F
40-49 years, male
28.3
GTEX-13OW7-0011-R1b-SM-5L3HF
50-59 years, male
28.3
GTEX-13SLW-0011-R1a-SM-5S2W7
70-79 years, male
28.1
GTEX-1HGF4-0011-R1a-SM-CJI3S
60-69 years, male
28.1
GTEX-1GMR8-0011-R1b-SM-CJI2O
50-59 years, female
26.8
GTEX-16Z82-0011-R1b-SM-7EPHZ
60-69 years, male
26.4
GTEX-P44G-0011-R1A-SM-2I3FE
30-39 years, male
26.2
GTEX-12WSD-0011-R1b-SM-5LZVY
60-69 years, female
26.1
GTEX-14PJO-0011-R1b-SM-6AJAK
60-69 years, male
26.1
GTEX-17F97-0011-R1b-SM-7IGM9
50-59 years, male
25.8
GTEX-11UD1-0011-R1b-SM-5BC7D
40-49 years, female
25.7
GTEX-13OW8-0011-R1a-SM-5L3HI
60-69 years, male
25.7
GTEX-15CHQ-0011-R1a-SM-COH27
60-69 years, male
25.7
GTEX-14PJM-0011-R1a-SM-CNPO3
50-59 years, female
25.5
GTEX-17HG3-0011-R1a-SM-7LG6H
30-39 years, female
25.4
GTEX-13FHP-0011-R1b-SM-5K7XL
50-59 years, male
25.3
GTEX-1H1CY-0011-R1a-SM-CKZOZ
60-69 years, female
25.3
GTEX-1IKK5-0011-R1b-SM-CE6SQ
60-69 years, male
25.3
GTEX-13O3Q-0011-R1b-SM-5KM3L
50-59 years, male
25.2
GTEX-11WQC-0011-R1b-SM-DO932
60-69 years, male
25.2
GTEX-17JCI-0011-R1b-SM-718A3
60-69 years, female
25.1
GTEX-11EI6-0011-R1a-SM-DO93L
60-69 years, male
24.7
GTEX-1H4P4-0011-R1b-SM-CL54V
50-59 years, male
24.7
GTEX-1I1GQ-0011-R1a-SM-CY8GG
50-59 years, male
24.7
GTEX-17MF6-0011-R1a-SM-72D6O
40-49 years, male
24.5
GTEX-11GS4-0011-R1a-SM-DO129
60-69 years, male
24.5
GTEX-13OW5-0011-R1b-SM-5L3GE
60-69 years, male
24.4
GTEX-17HHY-0011-R1a-SM-7189V
50-59 years, male
24.3
GTEX-11GSP-0011-R1a-SM-9QEJ3
60-69 years, female
24.3
GTEX-1EWIQ-0011-R1a-SM-9OSX7
70-79 years, female
24.3
GTEX-1HT8W-0011-R1b-SM-CJI3V
30-39 years, male
24.1
GTEX-1J1OQ-0011-R1a-SM-A9G1Z
40-49 years, female
24.0
GTEX-16NPV-0011-R1b-SM-7MGVZ
50-59 years, female
23.7
GTEX-1HR98-0011-R1a-SM-ARZLQ
60-69 years, male
23.7
GTEX-NL3H-0011-R1a-SM-48TDJ
60-69 years, male
23.5
GTEX-16GPK-0011-R1b-SM-7EWDH
60-69 years, male
23.4
GTEX-18A6Q-0011-R1b-SM-731DI
60-69 years, male
23.3
GTEX-Y8DK-0011-R1A-SM-4RGLO
60-69 years, male
23.3
GTEX-1GN2E-0011-R1b-SM-CE6RJ
60-69 years, male
23.3
GTEX-S7SE-0011-R1A-SM-2XCDE
50-59 years, male
23.2
GTEX-UTHO-0011-R1A-SM-3GIJO
60-69 years, male
23.0
GTEX-11ONC-0011-R1a-SM-57WD4
60-69 years, male
22.9
GTEX-13FXS-0011-R1a-SM-5K7U6
50-59 years, male
22.8
GTEX-13QJC-0011-R1b-SM-5S2UU
60-69 years, female
22.7
GTEX-11GSO-0011-R1b-SM-57WD3
60-69 years, male
22.5
GTEX-T5JC-0011-R1A-SM-32PM6
20-29 years, male
22.3
GTEX-15UF6-0011-R1a-SM-9QEGH
70-79 years, female
22.3
GTEX-144GO-0011-R1a-SM-5PNWO
60-69 years, male
22.2
GTEX-13CF2-0011-R1a-SM-5LZY1
60-69 years, male
21.9
GTEX-XMD1-0011-R1A-SM-4AT4C
60-69 years, male
21.8
GTEX-14C5O-0011-R1b-SM-6AJBW
60-69 years, male
21.1
GTEX-13PDP-0011-R1a-SM-5PNX5
60-69 years, male
21.0
GTEX-WWYW-0011-R1A-SM-3TW8G
50-59 years, female
21.0
GTEX-1H1DG-0011-R1b-SM-CKZP1
70-79 years, male
21.0
GTEX-1HBPI-0011-R1b-SM-A9SKF
50-59 years, male
20.9
GTEX-ZVZQ-0011-R1a-SM-57WBU
60-69 years, female
20.8
GTEX-PVOW-0011-R1A-SM-32PL6
40-49 years, male
20.7
GTEX-1I1GS-0011-R1a-SM-CJI43
60-69 years, male
20.7
GTEX-13JVG-0011-R1a-SM-5KM32
60-69 years, male
20.6
GTEX-139TT-0011-R1a-SM-5LZVD
60-69 years, male
20.5
GTEX-13N2G-0011-R1b-SM-5MR3G
60-69 years, male
20.5
GTEX-1ICLZ-0011-R1b-SM-A9SM3
60-69 years, male
20.5
GTEX-14ASI-0011-R1b-SM-5S2TY
60-69 years, male
20.3
GTEX-14E7W-0011-R1b-SM-5YYAT
70-79 years, male
20.3
GTEX-1GF9W-0011-R1a-SM-9QEIQ
60-69 years, male
20.2
GTEX-1E1VI-0011-R1a-SM-ARZMM
50-59 years, male
20.0
GTEX-13OW6-0011-R1a-SM-5L3HQ
50-59 years, male
19.8
GTEX-1GZ2Q-0011-R1a-SM-CJI2Y
40-49 years, male
19.8
GTEX-131YS-0011-R1a-SM-5DUXC
60-69 years, female
19.6
GTEX-13QIC-0011-R1a-SM-5O9CJ
60-69 years, female
19.5
GTEX-14PN4-0011-R1b-SM-69LP8
50-59 years, male
19.5
GTEX-13112-0011-R1b-SM-5HL7K
50-59 years, male
19.4
GTEX-11ZTS-0011-R1a-SM-5BC71
60-69 years, female
19.3
GTEX-12WSM-0011-R1a-SM-5LZW6
60-69 years, male
19.3
GTEX-11DXW-0011-R1a-SM-DNZZD
40-49 years, male
19.3
GTEX-14E6D-0011-R1b-SM-5YYAW
50-59 years, male
19.1
GTEX-1B996-0011-R1b-SM-7P8PO
60-69 years, male
19.1
GTEX-1I1GV-0011-R1a-SM-CL559
60-69 years, male
19.1
GTEX-13FTY-0011-R1a-SM-5LZXE
40-49 years, female
19.0
GTEX-145MH-0011-R1b-SM-5PNWY
50-59 years, male
19.0
GTEX-TSE9-0011-R1A-SM-3DB7E
60-69 years, female
19.0
GTEX-1EKGG-0011-R1b-SM-9QEI1
60-69 years, male
18.9
GTEX-1F6I4-0011-R1a-SM-9OSWU
60-69 years, male
18.9
GTEX-1GZHY-0011-R1a-SM-CE6RR
50-59 years, female
18.9
GTEX-1212Z-0011-R1b-SM-5BC72
60-69 years, male
18.7
GTEX-145LS-0011-R1b-SM-5PNUP
60-69 years, female
18.7
GTEX-1J8Q2-0011-R1a-SM-D4P2D
60-69 years, male
18.7
GTEX-1C6VR-0011-R1a-SM-7MXUE
60-69 years, male
18.6
GTEX-1GN1U-0011-R1a-SM-CJI25
50-59 years, female
18.5
GTEX-1GTWX-0011-R1a-SM-CE6RL
60-69 years, male
18.5
GTEX-N7MT-0011-R1a-SM-CNPO1
60-69 years, female
18.5
GTEX-13NZ8-0011-R1b-SM-5KM3V
60-69 years, female
18.4
GTEX-13FLW-0011-R1b-SM-5LZX2
50-59 years, male
18.3
GTEX-13OVJ-0011-R1b-SM-5L3I6
50-59 years, female
18.3
GTEX-ZE7O-0011-R1a-SM-57WDM
50-59 years, female
18.3
GTEX-13N1W-0011-R1b-SM-5MR4T
70-79 years, male
18.2
GTEX-14JIY-0011-R1a-SM-68713
60-69 years, male
18.2
GTEX-1GN73-0011-R1a-SM-CKZNT
60-69 years, male
18.2
GTEX-13OVL-0011-R1a-SM-5L3H5
50-59 years, male
17.7
GTEX-183WM-0011-R1a-SM-718A8
70-79 years, female
17.7
GTEX-1H3VE-0011-R1a-SM-A9G1K
40-49 years, male
17.7
GTEX-ZDXO-0011-R1a-SM-4WKF4
60-69 years, male
17.6
GTEX-1AX9I-0011-R1b-SM-7RHG2
60-69 years, male
17.6
GTEX-17EVQ-0011-R1a-SM-7189S
70-79 years, male
17.5
GTEX-1EX96-0011-R1a-SM-CE6R5
50-59 years, male
17.5
GTEX-1HSKV-0011-R1b-SM-CMKH7
60-69 years, male
17.5
GTEX-11ZVC-0011-R1b-SM-5BC6M
50-59 years, female
17.4
GTEX-12WSE-0011-R1b-SM-5GU4V
20-29 years, male
17.3
GTEX-15ER7-0011-R1b-SM-7KUE1
20-29 years, female
17.3
GTEX-1CB4J-0011-R1a-SM-9WG64
60-69 years, male
17.2
GTEX-13FHO-0011-R1b-SM-5KLZG
60-69 years, male
17.1
GTEX-1H23P-0011-R1a-SM-ACKVC
60-69 years, male
17.1
GTEX-13S7M-0011-R1b-SM-5PNZE
60-69 years, female
17.0
GTEX-16XZZ-0011-R1a-SM-7LTAH
60-69 years, male
16.9
GTEX-1F75A-0011-R1b-SM-CE6RA
50-59 years, male
16.9
GTEX-1IDJH-0011-R1b-SM-ARU6U
70-79 years, male
16.9
GTEX-17EVP-0011-R1a-SM-7DHLA
40-49 years, male
16.8
GTEX-NPJ7-0011-R1a-SM-3GACT
60-69 years, female
16.8
GTEX-13O3O-0011-R1b-SM-5KM2K
60-69 years, female
16.7
GTEX-11TUW-0011-R1a-SM-DO92S
60-69 years, male
16.7
GTEX-17HII-0011-R1b-SM-7MGVW
50-59 years, male
16.7
GTEX-1B8SF-0011-R1b-SM-7P8Q8
60-69 years, male
16.7
GTEX-1EH9U-0011-R1b-SM-CJI2B
60-69 years, male
16.7
GTEX-1F75W-0011-R1a-SM-ARU81
60-69 years, male
16.7
GTEX-1C6VQ-0011-R1a-SM-7P8Q2
50-59 years, male
16.6
GTEX-13X6I-0011-R1b-SM-5PNZC
60-69 years, male
16.4
GTEX-14PQA-0011-R1b-SM-6EU1G
50-59 years, female
16.4
GTEX-1H1ZS-0011-R1b-SM-A9G1E
70-79 years, male
16.3
GTEX-1A32A-0011-R1a-SM-7P8SQ
50-59 years, female
16.1
GTEX-YFC4-0011-R1a-SM-4V6EH
40-49 years, female
16.0
GTEX-13JUV-0011-R1a-SM-5LZY4
40-49 years, female
15.9
GTEX-N7MS-0011-R1a-SM-2HMJG
60-69 years, male
15.9
GTEX-R55E-0011-R1A-SM-2TC6N
20-29 years, male
15.9
GTEX-13G51-0011-R1a-SM-5LZYR
60-69 years, male
15.8
GTEX-14LZ3-0011-R1a-SM-69LP5
60-69 years, female
15.8
GTEX-OHPN-0011-R1A-SM-2I5GB
60-69 years, female
15.7
GTEX-WL46-0011-R1A-SM-3LK6M
50-59 years, male
15.6
GTEX-WZTO-0011-R1B-SM-3NMAR
40-49 years, male
15.5
GTEX-1B8L1-0011-R1a-SM-7P8SS
60-69 years, male
15.5
GTEX-1BAJH-0011-R1a-SM-7P8SV
70-79 years, male
15.5
GTEX-PWO3-0011-R1A-SM-2I5EW
60-69 years, female
15.4
GTEX-WHSE-0011-R1A-SM-3P5ZK
20-29 years, male
15.3
GTEX-131XH-0011-R1a-SM-5DUWA
50-59 years, male
15.2
GTEX-13RTJ-0011-R1a-SM-5O9D9
60-69 years, male
15.2
GTEX-ZAB4-0011-R1a-SM-4RGNO
40-49 years, male
15.2
GTEX-1B933-0011-R1b-SM-9QEGW
50-59 years, female
15.2
GTEX-1A3MX-0011-R1b-SM-7P8PH
60-69 years, male
15.0
GTEX-QMR6-0011-R1A-SM-32PKW
50-59 years, male
14.9
GTEX-13RTL-0011-R1a-SM-5PNZ8
40-49 years, male
14.8
GTEX-1E2YA-0011-R1b-SM-CJI29
50-59 years, male
14.7
GTEX-ZUA1-0011-R1a-SM-4YCE2
40-49 years, male
14.6
GTEX-1CB4G-0011-R1b-SM-9QEHT
60-69 years, male
14.5
GTEX-1IOXB-0011-R1a-SM-D4P27
50-59 years, male
14.4
GTEX-QVUS-0011-R1A-SM-3GAD2
60-69 years, female
14.2
GTEX-1EMGI-0011-R1b-SM-9OSWZ
60-69 years, male
14.1
GTEX-1H3NZ-0011-R1a-SM-CKZP5
60-69 years, male
14.1
GTEX-1LG7Y-0011-R1a-SM-EYYWV
50-59 years, male
14.1
GTEX-QVJO-0011-R1A-SM-2S1QI
60-69 years, female
14.0
GTEX-Q2AG-0011-R1A-SM-2HMJI
40-49 years, female
13.8
GTEX-1A8G6-0011-R1a-SM-7P8PC
60-69 years, male
13.8
GTEX-1I1HK-0011-R1b-SM-CM2T7
60-69 years, male
13.8
GTEX-P44H-0011-R1A-SM-3NM8J
40-49 years, male
13.7
GTEX-X4EP-0011-R1A-SM-3P624
60-69 years, female
13.7
GTEX-YJ89-0011-R1a-SM-4RGLS
60-69 years, male
13.6
GTEX-1F6IF-0011-R1b-SM-9WG78
60-69 years, male
13.3
GTEX-12WSF-0011-R1a-SM-5DUVI
70-79 years, male
13.2
GTEX-1C64N-0011-R1b-SM-7P8Q7
50-59 years, male
13.1
GTEX-14ABY-0011-R1a-SM-6EU2W
50-59 years, male
13.0
GTEX-1HSMO-0011-R1a-SM-CM2SV
60-69 years, male
13.0
GTEX-1313W-0011-R1b-SM-5EQ4A
50-59 years, female
12.8
GTEX-1IY9M-0011-R1a-SM-EXURZ
60-69 years, male
12.8
GTEX-X585-0011-R1B-SM-46MVE
50-59 years, male
12.2
GTEX-RNOR-0011-R1A-SM-CNNP5
50-59 years, female
12.0
GTEX-1LB8K-0011-R1b-SM-EZ6MV
50-59 years, male
11.4
GTEX-1F48J-0011-R1a-SM-9QEIC
50-59 years, female
11.3
GTEX-12ZZX-0011-R1a-SM-5EQ6B
40-49 years, female
10.8
GTEX-144GL-0011-R1a-SM-5PNZ5
50-59 years, male
10.8
GTEX-15DCD-0011-R1b-SM-6LPIJ
70-79 years, female
10.6
GTEX-NPJ8-0011-R1a-SM-33HCB
40-49 years, male
10.6
GTEX-13NZA-0011-R1b-SM-5LUAF
60-69 years, male
10.2
GTEX-12WSH-0011-R1a-SM-5GU5V
50-59 years, male
9.9
GTEX-14LLW-0011-R1a-SM-5ZZVD
70-79 years, female
9.7
GTEX-1CAV2-0011-R1a-SM-ARZML
40-49 years, female
9.2
GTEX-1H3O1-0011-R1b-SM-CL554
60-69 years, male
9.0
GTEX-16YQH-0011-R1a-SM-7LT8R
30-39 years, male
8.4
GTEX-145LU-0011-R1a-SM-5Q5CE
50-59 years, male
7.4
GTEX-T6MN-0011-R1A-SM-32QOY
50-59 years, male
7.4
GTEX-QDT8-0011-R1A-SM-32PKS
30-39 years, female
5.9
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HIPPOCAMPAL FORMATION - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.