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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Not detected
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
0.0
nTPM
HPA Brain:
0.3
nTPM
GTEx:
0.0
nTPM
FANTOM5:
0.0
Scaled Tags Per Million
Pig:
0.0
nTPM
Mouse:
0.3
nTPM
HIPPOCAMPUS - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA001349
Antibody CAB016527
Glial cells
Not detected
Not detected
Neuronal cells
Not detected
Medium
HIPPOCAMPAL FORMATION - HPA Brain RNA-seq
Max nTPM
0.3
Sample id
Sample description
nTPM
Hippocampus nTPM: 0.1
1855
Male, age 76, left hemisphere
0.2
2148
Female, age 91, left hemisphere
0.2
2621
Female, age 67, right hemisphere
0.2
1898
Male, age 80, left hemisphere
0.1
2529
Female, age 94, left hemisphere
0.1
1911
Female, age 85, right hemisphere
0.0
Dentate gyrus nTPM: 0.3
2531
Female, age 67, both hemispheres
1.1
2246
Female, age 85, both hemispheres
0.4
2528
Male, age 74, both hemispheres
0.3
2010
Male, age 76, both hemispheres
0.1
1927
Female, age 91, both hemispheres
0.0
2530
Female, age 94, left hemisphere
0.0
Entorhinal gyrus nTPM: 0.0
1787
Male, age 76, left hemisphere
0.0
1938
Female, age 85, left hemisphere
0.0
2117
Female, age 91, right hemisphere
0.0
2613
Female, age 94, left hemisphere
0.0
2686
Male, age 75, right hemisphere
0.0
2764
Male, age 80, right hemisphere
0.0
Hippocampus, CA1 nTPM: 0.2
2045
Male, age 76, both hemispheres
0.4
1873
Female, age 85, both hemispheres
0.2
2082
Female, age 91, right hemisphere
0.1
2749
Male, age 80, left hemisphere
0.1
2527
Male, age 74, both hemispheres
0.0
Hippocampus, CA2 nTPM: 0.0
1892
Male, age 76, both hemispheres
0.0
1940
Female, age 85, left hemisphere
0.0
1963
Male, age 80, left hemisphere
0.0
2113
Female, age 91, right hemisphere
0.0
2249
Male, age 74, both hemispheres
0.0
2437
Female, age 94, left hemisphere
0.0
Hippocampus, CA3 nTPM: 0.3
2861
Female, age 67, both hemispheres
0.8
2620
Female, age 94, left hemisphere
0.4
1891
Female, age 85, both hemispheres
0.2
2137
Male, age 80, left hemisphere
0.2
1867
Male, age 76, both hemispheres
0.1
2436
Male, age 74, both hemispheres
0.0
Parahippocampal cortex nTPM: 0.0
1933
Female, age 85, both hemispheres
0.2
1850
Male, age 80, both hemispheres
0.0
1990
Female, age 91, right hemisphere
0.0
2018
Male, age 76, both hemispheres
0.0
2245
Female, age 91, both hemispheres
0.0
2250
Female, age 67, right hemisphere
0.0
2532
Female, age 72, left hemisphere
0.0
2622
Female, age 67, right hemisphere
0.0
2692
Male, age 74, both hemispheres
0.0
2693
Female, age 94, both hemispheres
0.0
Perirhinal gyrus nTPM: 0.0
1794
Male, age 80, right hemisphere
0.0
1841
Female, age 85, right hemisphere
0.0
1847
Female, age 91, left hemisphere
0.0
2521
Female, age 94, right hemisphere
0.0
2848
Male, age 76, right hemisphere
0.0
Subiculum nTPM: 0.0
2729
Female, age 91, right hemisphere
0.3
1901
Male, age 80, both hemispheres
0.0
1977
Female, age 85, both hemispheres
0.0
2042
Male, age 76, both hemispheres
0.0
2438
Female, age 94, left hemisphere
0.0
2619
Male, age 74, both hemispheres
0.0
HIPPOCAMPAL FORMATION - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
0.0
GTEx sample id
Sample description
nTPM
Brain - Hippocampus Average nTPM: 0.0
Samples: 197
Max nTPM: 0.1
Min nTPM: 0.0
Std nTPM: 0.0
Median nTPM: 0.0
GTEX-13O3Q-0011-R1b-SM-5KM3L
50-59 years, male
0.1
GTEX-X4EP-0011-R1A-SM-3P624
60-69 years, female
0.1
GTEX-1B996-0011-R1b-SM-7P8PO
60-69 years, male
0.1
GTEX-11GSO-0011-R1b-SM-57WD3
60-69 years, male
0.0
GTEX-11ONC-0011-R1a-SM-57WD4
60-69 years, male
0.0
GTEX-11UD1-0011-R1b-SM-5BC7D
40-49 years, female
0.0
GTEX-11ZTS-0011-R1a-SM-5BC71
60-69 years, female
0.0
GTEX-11ZVC-0011-R1b-SM-5BC6M
50-59 years, female
0.0
GTEX-1212Z-0011-R1b-SM-5BC72
60-69 years, male
0.0
GTEX-12WSD-0011-R1b-SM-5LZVY
60-69 years, female
0.0
GTEX-12WSE-0011-R1b-SM-5GU4V
20-29 years, male
0.0
GTEX-12WSF-0011-R1a-SM-5DUVI
70-79 years, male
0.0
GTEX-12WSH-0011-R1a-SM-5GU5V
50-59 years, male
0.0
GTEX-12WSM-0011-R1a-SM-5LZW6
60-69 years, male
0.0
GTEX-12ZZX-0011-R1a-SM-5EQ6B
40-49 years, female
0.0
GTEX-13112-0011-R1b-SM-5HL7K
50-59 years, male
0.0
GTEX-1313W-0011-R1b-SM-5EQ4A
50-59 years, female
0.0
GTEX-131XH-0011-R1a-SM-5DUWA
50-59 years, male
0.0
GTEX-131YS-0011-R1a-SM-5DUXC
60-69 years, female
0.0
GTEX-132Q8-0011-R1a-SM-5EGLK
60-69 years, male
0.0
GTEX-1399T-0011-R1b-SM-5DUWN
60-69 years, male
0.0
GTEX-139T8-0011-R1a-SM-5HL75
60-69 years, male
0.0
GTEX-139TT-0011-R1a-SM-5LZVD
60-69 years, male
0.0
GTEX-13CF2-0011-R1a-SM-5LZY1
60-69 years, male
0.0
GTEX-13FHO-0011-R1b-SM-5KLZG
60-69 years, male
0.0
GTEX-13FHP-0011-R1b-SM-5K7XL
50-59 years, male
0.0
GTEX-13FLW-0011-R1b-SM-5LZX2
50-59 years, male
0.0
GTEX-13FTY-0011-R1a-SM-5LZXE
40-49 years, female
0.0
GTEX-13FXS-0011-R1a-SM-5K7U6
50-59 years, male
0.0
GTEX-13G51-0011-R1a-SM-5LZYR
60-69 years, male
0.0
GTEX-13JUV-0011-R1a-SM-5LZY4
40-49 years, female
0.0
GTEX-13JVG-0011-R1a-SM-5KM32
60-69 years, male
0.0
GTEX-13N1W-0011-R1b-SM-5MR4T
70-79 years, male
0.0
GTEX-13N2G-0011-R1b-SM-5MR3G
60-69 years, male
0.0
GTEX-13NYB-0011-R1b-SM-5KM4F
40-49 years, male
0.0
GTEX-13NYS-0011-R1b-SM-5MR55
60-69 years, male
0.0
GTEX-13NZ8-0011-R1b-SM-5KM3V
60-69 years, female
0.0
GTEX-13NZA-0011-R1b-SM-5LUAF
60-69 years, male
0.0
GTEX-13O3O-0011-R1b-SM-5KM2K
60-69 years, female
0.0
GTEX-13OVJ-0011-R1b-SM-5L3I6
50-59 years, female
0.0
GTEX-13OVL-0011-R1a-SM-5L3H5
50-59 years, male
0.0
GTEX-13OW5-0011-R1b-SM-5L3GE
60-69 years, male
0.0
GTEX-13OW6-0011-R1a-SM-5L3HQ
50-59 years, male
0.0
GTEX-13OW7-0011-R1b-SM-5L3HF
50-59 years, male
0.0
GTEX-13OW8-0011-R1a-SM-5L3HI
60-69 years, male
0.0
GTEX-13PDP-0011-R1a-SM-5PNX5
60-69 years, male
0.0
GTEX-13QIC-0011-R1a-SM-5O9CJ
60-69 years, female
0.0
GTEX-13QJC-0011-R1b-SM-5S2UU
60-69 years, female
0.0
GTEX-13RTJ-0011-R1a-SM-5O9D9
60-69 years, male
0.0
GTEX-13RTL-0011-R1a-SM-5PNZ8
40-49 years, male
0.0
GTEX-13S7M-0011-R1b-SM-5PNZE
60-69 years, female
0.0
GTEX-13SLW-0011-R1a-SM-5S2W7
70-79 years, male
0.0
GTEX-13X6I-0011-R1b-SM-5PNZC
60-69 years, male
0.0
GTEX-144GL-0011-R1a-SM-5PNZ5
50-59 years, male
0.0
GTEX-144GO-0011-R1a-SM-5PNWO
60-69 years, male
0.0
GTEX-145LS-0011-R1b-SM-5PNUP
60-69 years, female
0.0
GTEX-145LU-0011-R1a-SM-5Q5CE
50-59 years, male
0.0
GTEX-145MH-0011-R1b-SM-5PNWY
50-59 years, male
0.0
GTEX-14ABY-0011-R1a-SM-6EU2W
50-59 years, male
0.0
GTEX-14ASI-0011-R1b-SM-5S2TY
60-69 years, male
0.0
GTEX-14BIM-0011-R1a-SM-69LQI
60-69 years, female
0.0
GTEX-14C5O-0011-R1b-SM-6AJBW
60-69 years, male
0.0
GTEX-14E6D-0011-R1b-SM-5YYAW
50-59 years, male
0.0
GTEX-14E7W-0011-R1b-SM-5YYAT
70-79 years, male
0.0
GTEX-14JIY-0011-R1a-SM-68713
60-69 years, male
0.0
GTEX-14LLW-0011-R1a-SM-5ZZVD
70-79 years, female
0.0
GTEX-14LZ3-0011-R1a-SM-69LP5
60-69 years, female
0.0
GTEX-14PJO-0011-R1b-SM-6AJAK
60-69 years, male
0.0
GTEX-14PN4-0011-R1b-SM-69LP8
50-59 years, male
0.0
GTEX-14PQA-0011-R1b-SM-6EU1G
50-59 years, female
0.0
GTEX-15DCD-0011-R1b-SM-6LPIJ
70-79 years, female
0.0
GTEX-15ER7-0011-R1b-SM-7KUE1
20-29 years, female
0.0
GTEX-16GPK-0011-R1b-SM-7EWDH
60-69 years, male
0.0
GTEX-16XZZ-0011-R1a-SM-7LTAH
60-69 years, male
0.0
GTEX-16YQH-0011-R1a-SM-7LT8R
30-39 years, male
0.0
GTEX-16Z82-0011-R1b-SM-7EPHZ
60-69 years, male
0.0
GTEX-17EVP-0011-R1a-SM-7DHLA
40-49 years, male
0.0
GTEX-17EVQ-0011-R1a-SM-7189S
70-79 years, male
0.0
GTEX-17F97-0011-R1b-SM-7IGM9
50-59 years, male
0.0
GTEX-17HG3-0011-R1a-SM-7LG6H
30-39 years, female
0.0
GTEX-17HHY-0011-R1a-SM-7189V
50-59 years, male
0.0
GTEX-17JCI-0011-R1b-SM-718A3
60-69 years, female
0.0
GTEX-17MF6-0011-R1a-SM-72D6O
40-49 years, male
0.0
GTEX-183WM-0011-R1a-SM-718A8
70-79 years, female
0.0
GTEX-18A6Q-0011-R1b-SM-731DI
60-69 years, male
0.0
GTEX-N7MS-0011-R1a-SM-2HMJG
60-69 years, male
0.0
GTEX-NL3H-0011-R1a-SM-48TDJ
60-69 years, male
0.0
GTEX-NPJ7-0011-R1a-SM-3GACT
60-69 years, female
0.0
GTEX-NPJ8-0011-R1a-SM-33HCB
40-49 years, male
0.0
GTEX-OHPN-0011-R1A-SM-2I5GB
60-69 years, female
0.0
GTEX-P44G-0011-R1A-SM-2I3FE
30-39 years, male
0.0
GTEX-P44H-0011-R1A-SM-3NM8J
40-49 years, male
0.0
GTEX-PVOW-0011-R1A-SM-32PL6
40-49 years, male
0.0
GTEX-PWO3-0011-R1A-SM-2I5EW
60-69 years, female
0.0
GTEX-Q2AG-0011-R1A-SM-2HMJI
40-49 years, female
0.0
GTEX-QDT8-0011-R1A-SM-32PKS
30-39 years, female
0.0
GTEX-QMR6-0011-R1A-SM-32PKW
50-59 years, male
0.0
GTEX-QVJO-0011-R1A-SM-2S1QI
60-69 years, female
0.0
GTEX-QVUS-0011-R1A-SM-3GAD2
60-69 years, female
0.0
GTEX-R55E-0011-R1A-SM-2TC6N
20-29 years, male
0.0
GTEX-S7SE-0011-R1A-SM-2XCDE
50-59 years, male
0.0
GTEX-T5JC-0011-R1A-SM-32PM6
20-29 years, male
0.0
GTEX-T6MN-0011-R1A-SM-32QOY
50-59 years, male
0.0
GTEX-TSE9-0011-R1A-SM-3DB7E
60-69 years, female
0.0
GTEX-UTHO-0011-R1A-SM-3GIJO
60-69 years, male
0.0
GTEX-WHSE-0011-R1A-SM-3P5ZK
20-29 years, male
0.0
GTEX-WL46-0011-R1A-SM-3LK6M
50-59 years, male
0.0
GTEX-WVLH-0011-R1A-SM-4MVOK
50-59 years, male
0.0
GTEX-WWYW-0011-R1A-SM-3TW8G
50-59 years, female
0.0
GTEX-WZTO-0011-R1B-SM-3NMAR
40-49 years, male
0.0
GTEX-X4XX-0011-R1B-SM-3P622
60-69 years, male
0.0
GTEX-X585-0011-R1B-SM-46MVE
50-59 years, male
0.0
GTEX-XMD1-0011-R1A-SM-4AT4C
60-69 years, male
0.0
GTEX-Y8DK-0011-R1A-SM-4RGLO
60-69 years, male
0.0
GTEX-YFC4-0011-R1a-SM-4V6EH
40-49 years, female
0.0
GTEX-YJ89-0011-R1a-SM-4RGLS
60-69 years, male
0.0
GTEX-ZAB4-0011-R1a-SM-4RGNO
40-49 years, male
0.0
GTEX-ZDXO-0011-R1a-SM-4WKF4
60-69 years, male
0.0
GTEX-ZE7O-0011-R1a-SM-57WDM
50-59 years, female
0.0
GTEX-ZF28-0011-R1a-SM-4WWD1
60-69 years, male
0.0
GTEX-ZUA1-0011-R1a-SM-4YCE2
40-49 years, male
0.0
GTEX-ZVZQ-0011-R1a-SM-57WBU
60-69 years, female
0.0
GTEX-11DXW-0011-R1a-SM-DNZZD
40-49 years, male
0.0
GTEX-11EI6-0011-R1a-SM-DO93L
60-69 years, male
0.0
GTEX-11GS4-0011-R1a-SM-DO129
60-69 years, male
0.0
GTEX-11GSP-0011-R1a-SM-9QEJ3
60-69 years, female
0.0
GTEX-11TUW-0011-R1a-SM-DO92S
60-69 years, male
0.0
GTEX-11WQC-0011-R1b-SM-DO932
60-69 years, male
0.0
GTEX-14PJM-0011-R1a-SM-CNPO3
50-59 years, female
0.0
GTEX-15CHQ-0011-R1a-SM-COH27
60-69 years, male
0.0
GTEX-15UF6-0011-R1a-SM-9QEGH
70-79 years, female
0.0
GTEX-16NPV-0011-R1b-SM-7MGVZ
50-59 years, female
0.0
GTEX-17HII-0011-R1b-SM-7MGVW
50-59 years, male
0.0
GTEX-1A32A-0011-R1a-SM-7P8SQ
50-59 years, female
0.0
GTEX-1A3MX-0011-R1b-SM-7P8PH
60-69 years, male
0.0
GTEX-1A8G6-0011-R1a-SM-7P8PC
60-69 years, male
0.0
GTEX-1AX9I-0011-R1b-SM-7RHG2
60-69 years, male
0.0
GTEX-1B8L1-0011-R1a-SM-7P8SS
60-69 years, male
0.0
GTEX-1B8SF-0011-R1b-SM-7P8Q8
60-69 years, male
0.0
GTEX-1B933-0011-R1b-SM-9QEGW
50-59 years, female
0.0
GTEX-1BAJH-0011-R1a-SM-7P8SV
70-79 years, male
0.0
GTEX-1C64N-0011-R1b-SM-7P8Q7
50-59 years, male
0.0
GTEX-1C6VQ-0011-R1a-SM-7P8Q2
50-59 years, male
0.0
GTEX-1C6VR-0011-R1a-SM-7MXUE
60-69 years, male
0.0
GTEX-1CAV2-0011-R1a-SM-ARZML
40-49 years, female
0.0
GTEX-1CB4G-0011-R1b-SM-9QEHT
60-69 years, male
0.0
GTEX-1CB4J-0011-R1a-SM-9WG64
60-69 years, male
0.0
GTEX-1E1VI-0011-R1a-SM-ARZMM
50-59 years, male
0.0
GTEX-1E2YA-0011-R1b-SM-CJI29
50-59 years, male
0.0
GTEX-1EH9U-0011-R1b-SM-CJI2B
60-69 years, male
0.0
GTEX-1EKGG-0011-R1b-SM-9QEI1
60-69 years, male
0.0
GTEX-1EMGI-0011-R1b-SM-9OSWZ
60-69 years, male
0.0
GTEX-1EWIQ-0011-R1a-SM-9OSX7
70-79 years, female
0.0
GTEX-1EX96-0011-R1a-SM-CE6R5
50-59 years, male
0.0
GTEX-1F48J-0011-R1a-SM-9QEIC
50-59 years, female
0.0
GTEX-1F6I4-0011-R1a-SM-9OSWU
60-69 years, male
0.0
GTEX-1F6IF-0011-R1b-SM-9WG78
60-69 years, male
0.0
GTEX-1F75A-0011-R1b-SM-CE6RA
50-59 years, male
0.0
GTEX-1F75W-0011-R1a-SM-ARU81
60-69 years, male
0.0
GTEX-1GF9V-0011-R1a-SM-CKZNQ
60-69 years, male
0.0
GTEX-1GF9W-0011-R1a-SM-9QEIQ
60-69 years, male
0.0
GTEX-1GMR8-0011-R1b-SM-CJI2O
50-59 years, female
0.0
GTEX-1GN1U-0011-R1a-SM-CJI25
50-59 years, female
0.0
GTEX-1GN2E-0011-R1b-SM-CE6RJ
60-69 years, male
0.0
GTEX-1GN73-0011-R1a-SM-CKZNT
60-69 years, male
0.0
GTEX-1GTWX-0011-R1a-SM-CE6RL
60-69 years, male
0.0
GTEX-1GZ2Q-0011-R1a-SM-CJI2Y
40-49 years, male
0.0
GTEX-1GZHY-0011-R1a-SM-CE6RR
50-59 years, female
0.0
GTEX-1H1CY-0011-R1a-SM-CKZOZ
60-69 years, female
0.0
GTEX-1H1DG-0011-R1b-SM-CKZP1
70-79 years, male
0.0
GTEX-1H1ZS-0011-R1b-SM-A9G1E
70-79 years, male
0.0
GTEX-1H23P-0011-R1a-SM-ACKVC
60-69 years, male
0.0
GTEX-1H3NZ-0011-R1a-SM-CKZP5
60-69 years, male
0.0
GTEX-1H3O1-0011-R1b-SM-CL554
60-69 years, male
0.0
GTEX-1H3VE-0011-R1a-SM-A9G1K
40-49 years, male
0.0
GTEX-1H4P4-0011-R1b-SM-CL54V
50-59 years, male
0.0
GTEX-1HBPI-0011-R1b-SM-A9SKF
50-59 years, male
0.0
GTEX-1HGF4-0011-R1a-SM-CJI3S
60-69 years, male
0.0
GTEX-1HR98-0011-R1a-SM-ARZLQ
60-69 years, male
0.0
GTEX-1HSKV-0011-R1b-SM-CMKH7
60-69 years, male
0.0
GTEX-1HSMO-0011-R1a-SM-CM2SV
60-69 years, male
0.0
GTEX-1HT8W-0011-R1b-SM-CJI3V
30-39 years, male
0.0
GTEX-1I1GQ-0011-R1a-SM-CY8GG
50-59 years, male
0.0
GTEX-1I1GS-0011-R1a-SM-CJI43
60-69 years, male
0.0
GTEX-1I1GV-0011-R1a-SM-CL559
60-69 years, male
0.0
GTEX-1I1HK-0011-R1b-SM-CM2T7
60-69 years, male
0.0
GTEX-1ICLZ-0011-R1b-SM-A9SM3
60-69 years, male
0.0
GTEX-1IDJH-0011-R1b-SM-ARU6U
70-79 years, male
0.0
GTEX-1IKK5-0011-R1b-SM-CE6SQ
60-69 years, male
0.0
GTEX-1IOXB-0011-R1a-SM-D4P27
50-59 years, male
0.0
GTEX-1IY9M-0011-R1a-SM-EXURZ
60-69 years, male
0.0
GTEX-1J1OQ-0011-R1a-SM-A9G1Z
40-49 years, female
0.0
GTEX-1J8Q2-0011-R1a-SM-D4P2D
60-69 years, male
0.0
GTEX-1LB8K-0011-R1b-SM-EZ6MV
50-59 years, male
0.0
GTEX-1LG7Y-0011-R1a-SM-EYYWV
50-59 years, male
0.0
GTEX-N7MT-0011-R1a-SM-CNPO1
60-69 years, female
0.0
GTEX-RNOR-0011-R1A-SM-CNNP5
50-59 years, female
0.0
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HIPPOCAMPAL FORMATION - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.