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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Cells in glomeruli:
Not detected
Cells in tubules:
High
Protein profiling Multiplex tissuei
A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.
Cytoplasmic and plasma membranous staining in distal tubules. Additional cytoplasmic and plasma membranous staining in collecting ducts.
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
9.2
nTPM
HPA:
3.9
nTPM
GTEx:
9.2
nTPM
FANTOM5:
15.5
Scaled Tags Per Million
KIDNEY - Multiplex stainingi
Antibody localization in the annotated cell types/states of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state-specific markers, and subcellular location. The scores are based on multiplex immunohistochemistry profiling in selected tissues.
Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity,
while additional locations are characterized by lower overlap and weaker antibody signal intensity.
The antibody of interest is reported in green, while cell types/states are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.
- Antibody HPA060617
Main location
Distal tubules
Additional location
Collecting ducts
Antibody overlap
<25%
Location
Cytoplasm Plasma membrane
No antibody overlap
Antibody overlap
>75%
Location
Cytoplasm Plasma membrane
No antibody overlap
No antibody overlap
KIDNEY - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA053836
Antibody HPA060617
Cells in glomeruli
Not detected
Not detected
Cells in tubules
High
High
KIDNEY - HPA RNA-seqi
The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.
Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.
Average nTPM
3.9
Female, age 58
Kidney sample 55 nTPM: 4.7
Cell types%
Cells in tubules:
60
Cells in glomeruli:
20
Fibroblasts:
5
Other cell types:
15
Female, age 67
Kidney sample 56 nTPM: 4.4
Cell types%
Cells in tubules:
70
Cells in glomeruli:
15
Fibroblasts:
10
Other cell types:
5
Female, age 55
Kidney sample 57 nTPM: 7
Cell types%
Cells in tubules:
80
Cells in glomeruli:
10
Fibroblasts:
5
Other cell types:
5
Male, age 46
Kidney sample 58 nTPM: 3.2
Cell types%
Cells in tubules:
60
Cells in glomeruli:
25
Fibroblasts:
5
Other cell types:
10
Female, age 57
Kidney sample 358 nTPM: 2.8
Cell types%
Cells in tubules:
60
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
20
Male, age 78
Kidney sample 377 nTPM: 3.6
Cell types%
Cells in tubules:
65
Cells in glomeruli:
10
Fibroblasts:
5
Other cell types:
20
Male, age 73
Kidney sample 380 nTPM: 3.9
Cell types%
Cells in tubules:
60
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
20
Female, age 59
Kidney sample 394 nTPM: 3.9
Cell types%
Cells in tubules:
65
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
15
Female, age 48
Kidney sample 414 nTPM: 2
Cell types%
Cells in tubules:
60
Cells in glomeruli:
5
Fibroblasts:
10
Other cell types:
25
KIDNEY - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
9.2
GTEx sample id
Sample description
nTPM
Kidney - Cortex Average nTPM: 9.2
Samples: 85
Max nTPM: 29.2
Min nTPM: 0.5
Std nTPM: 6.0
Median nTPM: 7.8
GTEX-O5YV-1226-SM-EV795
60-69 years, female
29.2
GTEX-1GN1U-2126-SM-AHZ4J
50-59 years, female
29.1
GTEX-Y5V6-2026-SM-5IFHO
60-69 years, male
22.0
GTEX-14C39-2126-SM-664OH
40-49 years, male
20.2
GTEX-1GMR3-2426-SM-7MXV2
40-49 years, male
20.1
GTEX-1JJ6O-2526-SM-AHZ3J
60-69 years, male
19.7
GTEX-145MN-0326-SM-5QGQI
30-39 years, male
19.4
GTEX-14C5O-2026-SM-5YYB1
60-69 years, male
19.4
GTEX-P4QS-1126-SM-3NMD5
60-69 years, male
18.8
GTEX-12WSG-0826-SM-5EQ5A
50-59 years, female
16.6
GTEX-1BAJH-1826-SM-731DA
70-79 years, male
16.1
GTEX-1EKGG-2226-SM-7IGOA
60-69 years, male
15.6
GTEX-ZYFG-1626-SM-5GZYY
60-69 years, female
15.0
GTEX-RN64-1626-SM-48FD7
50-59 years, male
14.6
GTEX-1OJC4-2326-SM-DTXA5
50-59 years, female
14.5
GTEX-11GS4-2326-SM-5A5KS
60-69 years, male
14.0
GTEX-1K9T9-1826-SM-CXZK2
50-59 years, female
13.0
GTEX-REY6-1826-SM-EAZAT
60-69 years, male
12.6
GTEX-13RTJ-2226-SM-5S2Q1
60-69 years, male
12.3
GTEX-1C6VQ-2326-SM-7IGN1
50-59 years, male
12.2
GTEX-17F96-1926-SM-7MGWY
70-79 years, male
12.2
GTEX-1F48J-2226-SM-7MXTN
50-59 years, female
12.0
GTEX-1KWVE-0826-SM-CXZKO
30-39 years, male
11.9
GTEX-1QP6S-1526-SM-EXUSG
40-49 years, male
11.8
GTEX-11OF3-1326-SM-5N9FJ
60-69 years, male
11.5
GTEX-1HBPI-2026-SM-CE6RZ
50-59 years, male
11.4
GTEX-12696-0926-SM-5FQTV
60-69 years, male
11.2
GTEX-1GTWX-1826-SM-9QEHG
60-69 years, male
11.2
GTEX-1NV8Z-2226-SM-EXOJ2
60-69 years, male
11.2
GTEX-Y5V5-1226-SM-EYYVP
60-69 years, female
10.8
GTEX-1CB4J-1926-SM-7MGX8
60-69 years, male
10.5
GTEX-1JMLX-1526-SM-AHZ3N
50-59 years, male
10.5
GTEX-T5JC-1526-SM-4DM68
20-29 years, male
10.4
GTEX-ZC5H-1726-SM-5HL7X
40-49 years, female
10.3
GTEX-1I1GP-1926-SM-CNNQU
50-59 years, male
9.7
GTEX-15DYW-2026-SM-6AJBD
60-69 years, female
9.4
GTEX-ZYT6-2226-SM-5GIC9
30-39 years, male
9.3
GTEX-S33H-1426-SM-EZ6L7
30-39 years, male
9.3
GTEX-1GF9W-1326-SM-7P8PX
60-69 years, male
8.8
GTEX-17HHY-2326-SM-7KFSR
50-59 years, male
8.7
GTEX-QLQW-1626-SM-CMKFE
30-39 years, male
8.3
GTEX-1E2YA-1626-SM-7MGXS
50-59 years, male
8.2
GTEX-1GF9V-1926-SM-9JGHE
60-69 years, male
7.8
GTEX-1JMPZ-1226-SM-ARU8Y
30-39 years, male
7.8
GTEX-1PWST-2226-SM-EVR3G
70-79 years, male
7.7
GTEX-1A8FM-2026-SM-7P8RN
50-59 years, female
7.5
GTEX-13112-2126-SM-5GCO4
50-59 years, male
7.4
GTEX-1LG7Y-2726-SM-D5OVW
50-59 years, male
6.9
GTEX-13NYB-1726-SM-5N9G2
40-49 years, male
6.8
GTEX-XPVG-0526-SM-4B65N
50-59 years, male
6.7
GTEX-ZVZP-0926-SM-5GIDB
50-59 years, male
6.6
GTEX-1HCU7-1826-SM-A9G2A
50-59 years, male
6.6
GTEX-1JMQK-1926-SM-CJI3B
60-69 years, male
6.2
GTEX-1IKK5-0926-SM-A9G2U
60-69 years, male
6.1
GTEX-14E6D-2526-SM-5YYA9
50-59 years, male
5.8
GTEX-1R9PO-1626-SM-E6CPT
60-69 years, female
5.6
GTEX-T6MN-1826-SM-EXOHN
50-59 years, male
5.6
GTEX-1N2DW-1826-SM-EAZ54
50-59 years, male
5.2
GTEX-13OW6-1826-SM-5N9F9
50-59 years, male
4.9
GTEX-QDVN-1626-SM-48TZC
50-59 years, male
4.9
GTEX-1JMQJ-1726-SM-E9U4V
50-59 years, male
4.9
GTEX-147F4-2626-SM-5Q5CS
50-59 years, male
4.7
GTEX-ZDXO-0226-SM-4WKH7
60-69 years, male
4.7
GTEX-17F97-1926-SM-7IGM4
50-59 years, male
4.6
GTEX-13OVL-1826-SM-5KLZR
50-59 years, male
4.5
GTEX-1H3VY-1926-SM-9JGHJ
50-59 years, male
4.0
GTEX-1497J-0826-SM-5NQAJ
60-69 years, male
3.8
GTEX-16MT8-1926-SM-7EPGL
60-69 years, female
3.8
GTEX-1AX8Z-2326-SM-731CR
60-69 years, male
3.7
GTEX-1A3MW-2226-SM-73KUX
60-69 years, female
3.6
GTEX-ZLFU-0926-SM-5P9F8
40-49 years, male
3.6
GTEX-1H3NZ-2126-SM-9WPQ6
60-69 years, male
3.6
GTEX-NPJ8-2226-SM-3TW8D
40-49 years, male
3.4
GTEX-1MUQO-2526-SM-E9TJN
60-69 years, male
3.4
GTEX-15CHQ-2126-SM-6871M
60-69 years, male
3.2
GTEX-1399S-0526-SM-5IJG8
30-39 years, female
3.1
GTEX-13OVI-1126-SM-5KLZF
60-69 years, female
3.1
GTEX-1J1OQ-1426-SM-AHZ3P
40-49 years, female
2.4
GTEX-11TTK-1926-SM-5PNW8
60-69 years, female
2.2
GTEX-1N2EF-1426-SM-EXUSH
60-69 years, male
2.2
GTEX-13O1R-2526-SM-5N9FW
60-69 years, male
1.9
GTEX-QDT8-1726-SM-EYYV6
30-39 years, female
1.8
GTEX-1HB9E-1826-SM-D4P33
50-59 years, male
1.7
GTEX-1IL2V-1826-SM-ARU7R
70-79 years, male
1.6
GTEX-ZE9C-1426-SM-4WKGM
60-69 years, male
0.5
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Kidney - Medulla Average nTPM: 8.9
Samples: 4
Max nTPM: 12.4
Min nTPM: 6.2
Std nTPM: 2.2
Median nTPM: 8.5
GTEX-TKQ2-0626-SM-EZ6LB
50-59 years, male
12.4
GTEX-RU72-1926-SM-EAZ3F
50-59 years, female
8.8
GTEX-T5JC-1626-SM-EZ6KW
20-29 years, male
8.2
GTEX-R55E-2026-SM-EZ6L1
20-29 years, male
6.2
KIDNEY - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
The Human Protein Atlas project is funded
