Lung cancer Lung Adenocarcinoma (LUAD)Lung Squamous Cell Carcinoma (LUSC)

Lung cancer

The upper left dot plot(s) shows the consistency between the cancer type related cell lines and their corresponding TCGA disease cohort based on Spearman correlation and normalized enrichment score (NES). In the lower left is a list of the cell lines ranked according to their similarity to the cancer type. By clicking on a cell line in the dot plot or in the ranked list lollipop plots showing the activity of cancer-related pathways inferred using PROGENy and CytoSig cytokines for that particular cell line will be displayed. For more details about the analysis see Methods summary and information about all cell lines can be found here.

Lung Adenocarcinoma (LUAD)

Explore the disease cohort in TCGA

Ranking	Cell line	Corr	NES
1	NCI-H3255	0.79	2.2
2	HCC4006	0.78	2.14
2	NCI-H1734	0.78	2.32
4	RERF-LC-Ad1	0.78	2.12
5	NCI-H1648	0.79	1.94
5	NCI-H1781	0.78	2.08
7	NCI-H1869	0.78	2.07
7	NCI-H2347	0.77	2.13
9	HCC1195	0.77	2.07
9	NCI-H1437	0.77	2.05
11	HCC2935	0.78	1.9
12	HCC4011	0.77	1.93
13	HCC78	0.78	1.92
14	NCI-H2291	0.78	1.89
15	SW900	0.78	1.87
16	NCI-H2110	0.77	2.08
17	NCI-H2087	0.77	1.98
18	NCI-H441	0.76	2.09
19	NCI-H2122	0.77	1.91
20	EKVX	0.77	1.91
21	NCI-H1666	0.78	1.71
22	NCI-H3122	0.77	1.77
23	RERF-LC-KJ	0.77	1.81
24	HCC827 GR5	0.76	1.95
25	NCI-H2126	0.77	1.75
26	NCI-H1573	0.77	1.84
27	HCC2302	0.77	1.75
28	NCI-H1793	0.76	1.92
29	NCI-H2228	0.78	1.62
30	NCI-H1838	0.76	1.83
31	NCI-H727	0.75	2.04
32	NCI-H647	0.77	1.74
33	NCI-H2444	0.77	1.66
34	NCI-H1651	0.75	1.87
35	NCI-H1944	0.75	1.94
35	NCI-H2023	0.76	1.78
35	NCI-H2073	0.77	1.62
38	HCC364	0.76	1.74
39	NCI-H1568	0.75	1.93
40	MOR	0.75	1.84
41	HCC827	0.76	1.65
42	Calu-3	0.78	1.52
43	NCI-H2170	0.76	1.68
44	PC-14	0.77	1.6
45	RERF-LC-Ad2	0.76	1.62
46	NCI-H2342	0.75	1.74
47	NCI-H292	0.77	1.58
48	LCLC-97TM1	0.77	1.48
49	NCI-H358	0.75	1.77
50	Lu-65	0.74	1.77
51	HCC2279	0.76	1.51
51	RERF-LC-MS	0.76	1.59
53	NCI-H1395	0.75	1.64
54	HCC1171	0.77	1.47
55	MOR/CPR	0.75	1.64
56	A-549	0.75	1.63
57	DMS 53	0.73	1.88
58	BEN	0.73	1.85
58	HCC1833	0.73	1.86
58	NCI-H820	0.76	1.42
61	SK-MES-1	0.75	1.51
62	Sq-1	0.76	1.43
63	NCI-H2009	0.75	1.5
64	NCI-H1623	0.74	1.71
64	NCI-H854	0.74	1.61
66	HCC2270	0.75	1.56
67	KNS-62	0.77	1.33
67	LUDLU-1	0.76	1.4
69	IA-LM	0.73	1.71
69	NCI-H1435	0.76	1.39
71	NCI-H920	0.74	1.57
72	HCC15	0.76	1.4
73	NCI-H1355	0.74	1.61
74	HCC95	0.74	1.52
74	NCI-H2405	0.76	1.35
76	NCI-H460	0.73	1.74
77	NCI-H1819	0.73	1.73
78	PC-9	0.75	1.39
79	ABC-1	0.74	1.6
80	NCI-H1755	0.75	1.44
81	NCI-H1563	0.75	1.44
82	HCC515	0.75	1.36
82	NCI-H1650	0.75	1.35
84	NCI-H596	0.77	1.16
85	COR-L95	0.72	1.72
85	DV-90	0.74	1.48
87	NCI-H1373	0.76	1.23
88	NCI-H510A	0.7	1.87
89	COR-L23	0.74	1.48
90	ChaGo-K-1	0.74	1.49
91	HCC1588	0.75	1.31
92	NCI-H2198	0.72	1.69
93	HCC44	0.75	1.28
94	NCI-H1915	0.72	1.69
95	NCI-H2030	0.73	1.49
96	DMS 153	0.71	1.73
96	NCI-H2029	0.7	1.76
98	NCI-H2596	0.74	1.39
99	NCI-H157	0.72	1.62
100	T3M-10	0.77	1.05
101	NCI-H1975	0.75	1.21
102	COLO 668	0.71	1.64
103	NCI-H226	0.73	1.44
103	NCI-H2795	0.74	1.33
105	NCI-H2085	0.75	1.27
106	SHP-77	0.69	1.8
107	HCC2108	0.73	1.48
107	UMC-11	0.7	1.72
109	NCI-H1048	0.73	1.51
110	EPLC-272H	0.75	1.12
110	NCI-H2172	0.72	1.52
112	CAL-12T	0.75	1.22
112	NCI-H1792	0.75	1.22
114	NCI-H209	0.7	1.68
115	NCI-H2066	0.71	1.56
116	DMS 79	0.68	1.73
117	NCI-H2196	0.71	1.57
118	DMS 454	0.71	1.57
118	HCC1438	0.74	1.32
120	HCC2814	0.74	1.24
120	LXF 289	0.75	1.12
122	HCC366	0.74	1.25
122	NCI-H2887	0.74	1.29
122	RERF-LC-Sq1	0.74	1.31
125	NCI-H661	0.72	1.48
126	Calu-1	0.74	1.2
126	NCI-H1155	0.69	1.64
128	HOP-92	0.75	1.12
129	HOP-62	0.75	1.09
130	COR-L105	0.74	1.17
131	NCI-H1385	0.67	1.65
132	Calu-6	0.74	1.18
133	COR-L279	0.68	1.6
133	NCI-H2373	0.71	1.41
135	NCI-H2803	0.73	1.26
136	LCLC-103H	0.73	1.25
137	VMRC-LCD	0.69	1.51
138	NCI-H146	0.67	1.61
139	NCI-H1436	0.67	1.59
140	A-427	0.72	1.33
141	EBC-1	0.75	0.8
142	JL-1	0.74	1.05
143	COR-L311	0.67	1.53
143	SCLC-22H	0.69	1.5
145	HCC461	0.74	0.96
145	NCI-H2452	0.74	1.09
145	NCI-H322	0.74	1.04
145	HCC4017	0.74	1.08
149	NCI-H526	0.7	1.44
150	NCI-H1930	0.66	1.57
150	RERF-LC-A1	0.73	1.18
152	NCI-H187	0.66	1.55
153	COR-L88	0.69	1.43
153	HARA [Human squamous	0.73	1.14
153	NCI-H2369	0.74	1.1
156	LC-1F	0.73	1.11
157	NCI-H650	0.71	1.31
158	HCC193	0.75	0.77
159	NCI-H23	0.72	1.22
160	NCI-H28	0.73	1.17
161	NCI-H2882	0.73	1.18
161	LXFL 529L	0.68	1.45
163	NCI-H1618	0.7	1.36
164	NCI-H810	0.69	1.4
165	NCI-H1836	0.68	1.44
166	MPP 89	0.74	1.01
166	NCI-H2286	0.73	1.15
168	ACC-MESO-1	0.71	1.26
168	NCI-H520	0.71	1.26
170	NCI-H2052	0.74	0.75
171	SCLC-21H	0.69	1.37
172	NCI-H69	0.66	1.45
173	NCI-H889	0.68	1.38
174	HCC33	0.65	1.49
174	NCI-H2461	0.73	1.04
176	HCC1534	0.73	1.08
177	NCI-H211	0.69	1.29
177	NCI-H2595	0.74	0.59
179	NCI-H1693	0.73	1
180	HCC2885	0.73	1.05
181	SW1573	0.73	0.74
182	DMS 273	0.71	1.19
182	IST-Mes2	0.74	0.62
182	NCI-H838	0.71	1.19
185	IST-Mes1	0.73	0.83
185	NCI-H1184	0.66	1.36
185	NCI-H1581	0.69	1.25
188	LK-2	0.72	1.03
189	COR-L24	0.65	1.36
190	NCI-H1694	0.65	1.39
191	HCC1359	0.73	0.64
192	NCI-H345	0.65	1.35
192	RERF-LC-OK	0.71	1.11
194	COLO 699	0.7	1.15
195	LOU-NH91	0.72	0.97
196	SK-LU-1	0.72	0.92
196	NCI-H2804	0.73	0.71
198	NCI-H2227	0.65	1.34
198	NCI-H82	0.66	1.32
200	DMS 114	0.69	1.18
200	CPC-N	0.63	1.35
202	HCC2450	0.71	1.02
202	NCI-H196	0.72	0.86
204	SW1271	0.72	0.93
204	NCI-H2810	0.73	0.69
206	NCI-H1092	0.66	1.29
207	NCI-H524	0.65	1.31
207	COR-L26	0.67	1.24
209	Lu-99	0.73	0.64
210	COR-L47	0.67	1.21
210	NCI-H847	0.64	1.31
212	HCC2429	0.71	0.98
212	NCI-H2081	0.68	1.19
212	NCI-H1770	0.66	1.27
215	NCI-H2722	0.72	0.78
216	MSTO-211H	0.72	0.58
217	SBC-5	0.7	1.05
218	NCI-H1876	0.69	1.06
219	NCI-H1882	0.68	1.15
220	NCI-H2135	0.7	0.95
221	NCI-H1963	0.66	1.2
222	NCI-H2171	0.66	1.16
223	NCI-H446	0.69	1.05
223	NCI-H841	0.7	0.94
225	NCI-H1341	0.71	0.74
226	NCI-H1703	0.71	0.61
227	NCI-H522	0.7	0.81
228	NCI-H2077	0.69	0.99
229	NCI-H2106	0.66	1.09
230	NCI-H1299	0.7	0.54
231	NCI-H1105	0.66	1.06
232	NCI-N417	0.65	0.88

CELL LINE DATA
Cell line	NCI-H3255
Patient:	Female, 52
Disease subtype:	Non-Small Cell Lung Cancer (NSCLC), Adenocarcinoma
Primary/metastasis:	Primary
Sample collection site:	Lung
Cellosaurus:	CVCL_6831
PROGENy

CytoSig

Lung Squamous Cell Carcinoma (LUSC)

Explore the disease cohort in TCGA

Ranking	Cell line	Corr	NES
1	HCC2814	0.79	2.15
1	KNS-62	0.8	2.09
3	HCC95	0.79	2.16
4	LUDLU-1	0.79	2.15
4	NCI-H1648	0.79	1.95
6	EPLC-272H	0.79	1.74
6	NCI-H1666	0.79	1.7
8	LC-1F	0.78	1.99
9	NCI-H292	0.78	1.73
10	NCI-H596	0.79	1.66
11	PC-14	0.78	1.71
12	NCI-H1734	0.78	1.64
13	RERF-LC-MS	0.77	1.82
14	NCI-H1793	0.76	1.86
15	RERF-LC-Sq1	0.76	1.85
16	HARA [Human squamous	0.77	1.64
17	NCI-H2170	0.76	1.76
17	HCC2302	0.77	1.63
19	NCI-H1573	0.77	1.65
20	LXF 289	0.76	1.71
20	NCI-H2228	0.78	1.52
22	NCI-H2023	0.76	1.78
23	NCI-H1437	0.76	1.64
24	NCI-H1869	0.77	1.55
25	NCI-H3255	0.78	1.42
26	NCI-H647	0.77	1.45
27	EKVX	0.77	1.49
28	NCI-H322	0.76	1.66
28	PC-9	0.76	1.59
30	NCI-H2122	0.77	1.45
31	RERF-LC-Ad1	0.77	1.41
32	NCI-H1623	0.75	1.67
32	NCI-H1781	0.77	1.44
34	NCI-H1650	0.77	1.39
35	NCI-H2444	0.78	1.31
36	CAL-12T	0.76	1.47
37	NCI-H1755	0.75	1.66
38	HCC366	0.76	1.57
38	SK-MES-1	0.76	1.47
40	NCI-H1568	0.76	1.49
41	HCC15	0.75	1.57
42	NCI-H2126	0.77	1.39
43	Calu-3	0.77	1.33
44	HCC2935	0.78	1.28
44	NCI-H1435	0.76	1.51
44	NCI-H1792	0.76	1.46
44	MOR	0.76	1.43
48	LK-2	0.75	1.64
49	MOR/CPR	0.75	1.57
49	NCI-H2795	0.76	1.51
51	NCI-H2286	0.74	1.67
52	RERF-LC-Ad2	0.78	1.22
53	ChaGo-K-1	0.75	1.47
54	HCC2429	0.74	1.77
54	NCI-H2073	0.77	1.25
56	LCLC-103H	0.75	1.6
56	HCC4011	0.78	1.17
58	NCI-H2085	0.76	1.34
58	NCI-H2405	0.77	1.28
60	NCI-H157	0.74	1.74
60	NCI-H1944	0.74	1.63
62	NCI-H920	0.75	1.41
63	NCI-H2110	0.76	1.31
64	HCC1438	0.75	1.42
65	HCC4006	0.78	1.12
66	NCI-H1341	0.74	1.64
67	NCI-H226	0.75	1.47
68	NCI-H2342	0.75	1.43
69	A-427	0.73	1.65
69	BEN	0.72	1.82
71	NCI-H520	0.74	1.62
72	NCI-H460	0.74	1.51
72	NCI-H820	0.77	1.17
74	SBC-5	0.72	1.84
75	NCI-H661	0.74	1.59
76	T3M-10	0.78	1.05
77	NCI-H2087	0.76	1.18
78	NCI-H1355	0.74	1.42
79	NCI-H2009	0.76	1.17
80	COR-L23	0.75	1.32
81	NCI-H2347	0.77	1.11
82	A-549	0.75	1.25
83	NCI-H650	0.73	1.56
84	SW900	0.78	0.98
85	ABC-1	0.75	1.29
86	NCI-H441	0.75	1.27
86	RERF-LC-A1	0.75	1.36
88	DV-90	0.74	1.39
89	LCLC-97TM1	0.77	1.01
90	MPP 89	0.75	1.24
91	NCI-H2291	0.77	1
92	DMS 454	0.7	1.67
93	HCC78	0.77	1.01
94	NCI-H2803	0.74	1.34
95	HCC44	0.76	1.09
95	JL-1	0.76	1.14
97	NCI-H3122	0.77	0.99
98	NCI-H1373	0.76	1.01
98	NCI-H841	0.72	1.51
100	DMS 114	0.71	1.53
100	NCI-H2066	0.72	1.48
100	NCI-H510A	0.71	1.53
103	NCI-H2887	0.74	1.37
104	HCC2270	0.76	1.1
105	IST-Mes1	0.75	1.23
106	DMS 53	0.72	1.45
107	UMC-11	0.69	1.62
108	NCI-H2172	0.73	1.38
109	RERF-LC-KJ	0.76	1.05
110	NCI-H2882	0.74	1.3
111	NCI-H727	0.73	1.35
112	RERF-LC-OK	0.72	1.39
113	NCI-H1651	0.75	1.09
114	NCI-H1299	0.72	1.4
114	NCI-H196	0.74	1.29
116	SCLC-21H	0.7	1.49
116	NCI-H810	0.69	1.53
116	HCC193	0.76	1.06
119	HOP-62	0.76	0.9
119	NCI-H1618	0.71	1.42
119	NCI-H358	0.75	1.16
122	NCI-H2227	0.67	1.66
123	HCC1171	0.77	0.58
124	HCC2279	0.76	0.86
124	NCI-H1930	0.68	1.57
126	HCC461	0.76	1.02
126	NCI-H1975	0.76	0.96
128	NCI-H146	0.69	1.54
129	Sq-1	0.76	0.95
130	NCI-H1563	0.75	1.04
130	NCI-H69	0.68	1.52
132	HCC1534	0.74	1.24
133	HCC2108	0.74	1.18
134	NCI-H2596	0.75	1.03
135	NCI-H23	0.74	1.14
136	NCI-H2052	0.76	0.96
137	HCC1195	0.76	0.86
138	HCC827	0.77	0.58
139	EBC-1	0.76	0.88
140	SHP-77	0.69	1.44
141	NCI-H1882	0.7	1.39
142	NCI-H1819	0.74	1.14
143	IST-Mes2	0.75	1.04
143	NCI-H1048	0.75	1.08
143	LXFL 529L	0.7	1.38
146	NCI-H838	0.72	1.25
147	HOP-92	0.75	0.92
148	NCI-H1838	0.76	0.86
149	HCC364	0.76	0.78
149	HCC4017	0.75	1.01
151	HCC2450	0.73	1.2
151	NCI-H1693	0.74	1.08
151	SW1271	0.73	1.17
154	NCI-H1915	0.72	1.22
154	SCLC-22H	0.7	1.36
154	VMRC-LCD	0.7	1.36
157	NCI-H2029	0.7	1.33
158	NCI-H2196	0.72	1.27
159	DMS 273	0.73	1.17
160	NCI-H854	0.73	1.17
161	NCI-H2081	0.69	1.35
162	IA-LM	0.74	1.12
162	NCI-H1836	0.69	1.38
162	NCI-H2595	0.76	0.65
165	NCI-H1694	0.68	1.4
165	NCI-H187	0.68	1.41
167	HCC1833	0.72	1.21
168	COR-L105	0.75	0.89
168	COR-L24	0.67	1.4
168	HCC827 GR5	0.75	0.86
168	NCI-H889	0.69	1.34
168	NCI-H2369	0.75	0.97
173	Calu-1	0.75	0.85
174	HCC1588	0.74	1.04
174	NCI-H2198	0.72	1.16
176	NCI-H209	0.71	1.23
177	COR-L47	0.69	1.3
177	NCI-H1703	0.73	1.13
179	NCI-H1155	0.71	1.22
180	HCC2885	0.74	0.98
181	COLO 699	0.72	1.16
182	COR-L88	0.7	1.21
183	NCI-N417	0.68	1.33
184	NCI-H1436	0.69	1.28
185	NCI-H2171	0.69	1.25
185	NCI-H2452	0.75	0.58
187	NCI-H82	0.68	1.3
188	COR-L95	0.73	1.09
189	DMS 153	0.72	1.13
189	NCI-H446	0.71	1.16
189	NCI-H2804	0.74	0.84
192	Calu-6	0.75	0.65
192	COR-L279	0.69	1.21
194	SW1573	0.75	0.65
195	HCC33	0.67	1.32
195	NCI-H1876	0.72	1.12
197	NCI-H2030	0.74	0.92
197	NCI-H2461	0.75	0.68
197	NCI-H2722	0.74	1.01
200	HCC1359	0.75	0.5
201	HCC515	0.75	0.6
202	NCI-H1385	0.67	1.28
203	NCI-H28	0.74	0.96
204	DMS 79	0.7	1.16
204	NCI-H526	0.71	1.12
204	NCI-H2373	0.73	1.03
207	NCI-H1581	0.71	1.12
208	MSTO-211H	0.74	0.77
208	NCI-H211	0.71	1.09
210	NCI-H522	0.72	1.04
211	Lu-99	0.74	0.62
211	NCI-H2810	0.74	0.61
213	COR-L311	0.69	1.15
213	NCI-H524	0.68	1.19
215	Lu-65	0.74	0.63
216	NCI-H2106	0.68	1.14
216	SK-LU-1	0.74	0.63
216	CPC-N	0.65	1.2
219	NCI-H1395	0.73	0.81
220	COLO 668	0.7	1.05
221	ACC-MESO-1	0.72	0.79
221	LOU-NH91	0.73	0.65
223	NCI-H1184	0.68	1.12
224	COR-L26	0.67	1.13
224	NCI-H847	0.67	1.16
226	NCI-H2077	0.7	0.87
227	NCI-H2135	0.71	0.75
228	NCI-H1105	0.68	1
228	NCI-H1770	0.67	1.03
230	NCI-H1963	0.68	0.87
230	NCI-H345	0.67	0.97
232	NCI-H1092	0.67	0.82

CELL LINE DATA
Cell line	HCC2814
Patient:	Male, 55
Disease subtype:	Non-Small Cell Lung Cancer (NSCLC), Squamous Cell Carcinoma
Primary/metastasis:
Sample collection site:	Lung
Cellosaurus:	CVCL_V586
PROGENy

CytoSig