Cell line expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in.	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function.	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Neuronal	Visual perception	227	Medium
2	Mucus-secreting cells	Unknown function	94	Medium
3	Rhabdoid	Membrane components	129	Low
4	Non-specific	Transcription	500	High
5	Rhabdoid	Unknown function	423	Medium
6	Leukemia	Signal transduction	196	Medium
7	Liver cancer	Metabolism	312	Medium
8	Non-specific	Basic cellular processes	177	Medium
9	Skin cancer	Melanin biosynthesis	199	Medium
10	Ciliated cells	Ion channel activity	610	Low
11	Neuronal	Sensory perception	177	Low
12	Bone cancer	Neuronal signaling	237	Medium
13	Non-specific	Mixed function	151	Low
14	Myeloid leukemia	Innate immune response	453	High
15	Kidney cancer	Membrane components	689	Low
16	Thyroid cancer	Neuronal signaling	242	Low
17	Neuroblastoma	Neuronal signaling	400	Medium
18	Liver cancer	Metabolism	215	High
19	Non-specific	Unknown function	130	High
20	Myeloma	Immune response	89	Medium
21	Lymphoma	Adaptive immune response	117	Low
22	Non-specific	mRNA splicing & Cell cycle	414	Medium
23	Non-specific	Transcription	236	Medium
24	Non-specific	Unknown function	427	Medium
25	Non-specific	Ribosome	130	High
26	Non-specific	Mitochondria & RNA binding	312	Medium
27	Breast cancer	Unknown function	687	Low
28	Non-specific	Nuclear processes	266	Medium
29	Non-specific	Unknown function	48	High
30	Non-specific	Gene expression regulation	362	Medium
31	Non-specific	Antiviral immune response	108	Medium
32	Non-specific	Cell proliferation	122	Very low
33	Sarcoma	Muscle contraction	159	Medium
34	Testis cancer	Unknown function	159	Low
35	RS4;11	Unknown function	154	Low
36	Non-specific	mRNA processing	220	Medium
37	Non-specific	mRNA processing	355	Low
38	Non-specific	Transcription	299	High
39	Non-specific	Transcription	233	High
40	Non-specific	Unknown function	259	High
41	Non-specific	Nucleosome assembly	70	Medium
42	Non-specific	Unknown function	149	Medium
43	Non-specific	Basic cellular processes	232	Medium
44	Connective tissue cells	ECM organization	165	Medium
45	Non-specific	Nuclear processes	294	Medium
46	Lymphoma	Humoral immune response	454	Medium
47	Leukemia	Hemostasis	382	Low
48	Adipocytes & Endothelial cells	Angiogenesis	112	Medium
49	HMC-1	Innate immune response	136	Medium
50	Lymphoma	Unknown function	88	Medium
51	Myeloma	Immunoglobulins	676	Medium
52	Non-specific	Mitochondria	220	Low
53	Squamous epithelial cells	Keratinization	967	Medium
54	Non-specific	Transcription	224	Low
55	Lymphoma	Immune response	400	Medium
56	Non-specific	Sensory perception	262	Low
57	Stomach & Colon cancer	Digestion	414	Medium
58	Non-specific	Nuclear processes	191	Low
59	Leukemia	T-cell receptor	439	Medium
60	Prostate cancer	Unknown function	146	High
61	BICR 18	Protein kinases	75	Very low
62	Non-specific	Plasma proteins	192	Low
63	Non-specific	Protein processing	236	Medium
64	Connective tissue cells	ECM organization	527	Medium
65	Non-specific	Unknown function	103	Low
66	Non-specific	Mitochondria	222	Low
67	Non-specific	Unknown function	133	Medium
68	Non-specific	Cell cycle regulation	172	Medium
69	Skin cancer	ECM organization	288	Medium
70	DU4475	Unknown function	120	Medium
71	Lymphoma	Inflammatory response	258	Low
72	Neuronal	Signal transduction	444	Low

The interactive UMAP plot displays the 72 gene clusters resulting from Louvain clustering of gene expression across all cell lines. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all cell lines for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.

Bone cancer, Lymphoma
Brain cancer, Neuroblastoma
Colorectal cancer, Gastric cancer, Head and Neck cancer
Bladder cancer, Kidney cancer
Bile duct cancer, Gallbladder cancer, Liver cancer
Myeloma
Prostate cancer, Sarcoma, Testis cancer
Rhabdoid
Skin cancer
Adrenocortical cancer, Leukemia, Thyroid cancer
Breast cancer, Cervical cancer, Ovarian cancer, Uterine cancer
Other
Non-Specific