Cell lines

Name	Description of cell line	Original reference	Origin	Sex & Age	Source	Cellosaurus (ExPaSy)
Brain
AF22	iPS derived Neuroepithelia stem (NES) cell line	Falk et al., PLoS One 7(1) (2012)	Skin	Female, 36	NA	Uncategorised
U-251MG	Glioblastoma cell line	Westermark B., Int J Cancer12: 438 (1973)	Brain	Male	BW¹	CVCL_0021 Cancer cell line
GAMG	Glioblastoma cell line	Akslen et al, Anticancer Res. 8(4): 797-803 (1988)		Female, 42	DSMZ	CVCL_1226 Cancer cell line
SH-SY5Y	Metastatic neuroblastoma, clonal subline of neuroepithelioma cell line SK-N-SH	Biedler et al., Cancer Res 33: 2643 (1973)	Bone marrow	Female, 4	DSMZ	CVCL_0019 Cancer cell line
Eye
HTCEpi	Telomerase-immortalized corneal epithelial cell line	Robertson et al., Invest Ophthalmol Vis Sci 46(2): 470-478 (2005)	Cornea	Male, 62	Evercyte	CVCL_AQ44 Telomerase immortalized cell line
HTERT-RPE1 (serum starved)	Retinal pigment epithelial cells immortalized with hTERT	Rambhatla L et al.. Invest Ophthalmol Vis Sci. 43(5):1622-30. (2002)	Retina, eye	Female, 1		CVCL_4388 Telomerase immortalized cell line
HTERT-RPE1	Retinal pigment epithelial cells immortalized with hTERT	Rambhatla L et al.. Invest Ophthalmol Vis Sci. 43(5):1622-30. (2002)	Retina, eye	Female, 1		CVCL_4388 Telomerase immortalized cell line
Proximal digestive tract
OE19	Esophageal adenocarcinoma cell line	PMID: 9010035	Esophagus	Male, 72	DSMZ	CVCL_1622 Cancer cell line
Gastrointestinal tract
CACO-2	Colon adenocarcinoma cell line	Fogh J., et al. J. Natl. Cancer Inst. 58: 209 (1977)	Colon	Male, 72	DSMZ	CVCL_0025 Cancer cell line
Liver & Gallbladder
Hep-G2	Hepatocellular carcinoma cell line	Aden et al., Nature 282: 615 (1979)	Liver	Male, 15	DSMZ	CVCL_0027 Cancer cell line
Kidney & Urinary bladder
RT-4	Urinary bladder transitional cell carcinoma cell line	Rigby et al., Br J Cancer 24: 746 (1970)	Urinary bladder	Male, 63	DSMZ/ECACC	CVCL_0036 Cancer cell line
RPTEC/TERT1	Proximal tubular epithelial cell line	Wieser et al., Am J Physiol Renal Physiol 295(5): 1365-1375 (2008)	Human kidney cortex	Male	Evercyte	CVCL_K278 Telomerase immortalized cell line
HEK293	Embryonal kidney cell line, transformed by adenovirus type 5	Graham et al., J Gen Virol 36: 59 (1977)	Embryonal kidney	Female	DSMZ	CVCL_0045 Transformed cell line
Male reproductive system
SuSa	Testicular germ cell tumor	PMID: 593370	Testis	Male, 30	DSMZ	CVCL_L280 Cancer cell line
PC-3	Metastatic poorly differentiated prostate adenocarcinoma cell line	Kaighn et al., Invest Urol 17: 16-23 (1979)	Bone marrow	Male, 62	DSMZ	CVCL_0035 Cancer cell line
Skin
HaCaT	Keratinocyte cell line	Boukamp et al., J Cell Biol Mar 106(3): 761 (1988)	Skin	Male	NEF²	CVCL_0038 Spontaneously immortalized cell line
SK-MEL-30	Metastatic malignant melanoma cell line	Carey et al., Proc Natl Acad Sci USA 73: 3278 (1976)	Subcutis	Male, 67	DSMZ	CVCL_0039 Cancer cell line
A-431	Epidermoid carcinoma cell line	Giard et al., J Natl Cancer Inst 51: 1417 (1973)	Skin	Female, 85	DSMZ	CVCL_0037 Cancer cell line
Lung
A-549	Lung carcinoma cell line	Giard et al., J Natl Cancer Inst 51: 1417 (1973)	Lung	Male, 58	DSMZ	CVCL_0023 Cancer cell line
HBEC3-KT	Immortalized human bronchial epithelial cell line		Central lung bronchiole	Female, 65	Evercyte	CVCL_X491 Telomerase immortalized cell line
Female reproductive system
HTERT-HME1	Immortalized mammary epithelial cell line		Mammary gland	Female, 53	Evercyte	CVCL_3383 Telomerase immortalized cell line
HeLa	Cervical epithelial adenocarcinoma cell line	Scherer et al., J Exp Med 97: 695 (1953)	Cervix	Female, 31	DSMZ	CVCL_0030 Cancer cell line
MCF-7	Metastatic breast adenocarcinoma cell line	Soule et al., J Natl Cancer Inst 51: 1409 (1973)	Pleural effusion	Female, 69	DSMZ	CVCL_0031 Cancer cell line
EFO-21	Metastatic ovarian serous cystadenocarcinoma cell line	Simon et al., J Natl Cancer Inst 70: 839 (1983)	Ascites	Female, 56	DSMZ	CVCL_0029 Cancer cell line
SiHa	Cervical squamous cell carcinoma cell line, integrated 1-2 copies of HPV16	Friedl F. et al.Proc., Soc. Exp. Biol. Med. 135: 543-545 (1970)	Cervix	Female, 55	LGC/ATCC	CVCL_0032 Cancer cell line
Endothelial
HUVEC/TERT2	Umbilical vein endothelial cell line	NA	Umbilical vein	Female	Evercyte	CVCL_9Q53 Telomerase immortalized cell line
Mesenchymal
Rh30	Metastatic rhabdomyosarcoma cell line	Douglass et al., Cytogenet Cell Genet 45: 148-155 (1987)	Bone marrow	Male, 17	DSMZ	CVCL_0041 Cancer cell line
ASC52telo	Adipose tissue-derived mesenchymal stem cell line	Wolbank S. et al., Tissue Eng Part A: Jul;15(7):1843-54 (2009)	Adipose tissue	Female	Evercyte	CVCL_U602 Telomerase immortalized cell line
U2OS	Osteosarcoma cell line	Ponten J., Saksela E. Int. J. Cancer 2: 434 (1967)	Bone	Female, 15	LGC/ATCC	CVCL_0042 Cancer cell line
BJ [Human fibroblast]	Adherent fibroblast cell line	Bodnar AG., et al. Science 279: 349-352 (1998)	Foreskin	Male	LGC/ATCC	CVCL_3653 Finite cell line
FHDF/TERT166	Immortalized human foreskin fibroblast cell line		Foreskin	Male	Evercyte	CVCL_GZ73 Telomerase immortalized cell line
HBF/TERT88	Adherent brain fibroblast cell line	NA	Brain	Female	Evercyte	CVCL_9Q52 Telomerase immortalized cell line
LHCN-M2	Adherent myoblast cell line	Zhu et al., Aging Cell 6(4): 515-523 (2007)	Satellite cells (from pectoralis major muscle)	Male, 41	Evercyte	CVCL_8890 Telomerase immortalized cell line
Lymphoid
HTEC/SVTERT24-B	Immortalized thymic epithelial cell line		Thymus	Female	Evercyte	CVCL_JM27 Transformed cell line
REH**	Pre-B cell leukemia cell line (ALL, first relapse)	Rosenfeld et al., Nature 267: 841–3 (1977)	Peripheral blood	Female, 15	DSMZ	CVCL_1650 Cancer cell line
HDLM-2	Hodgkin lymphoma cell line	Drexler et al., Leuk Res 10: 487 (1986)	Pleural effusion	Male, 74	DSMZ	CVCL_0009 Cancer cell line
JURKAT	T-cell leukemia cell line		Peripheral blood	Male, 14	DSMZ	CVCL_0065 Cancer cell line
Myeloid
HAP1	Haploid karyotype cell line from Chronic myelogenous leukemia	Carette et al., Nature 477(7364): 340-343 (2011)	Leukemia	Male	Horizon Discovery	CVCL_Y019 Cancer cell line
HEL	Erythroleukemia cell line (AML M6 in relapse after treatment for Hodgkin's disease)	Martin et al., Science 216: 1233 (1982)	Peripheral blood	Male, 30	DSMZ	CVCL_0001 Cancer cell line
NB4	Acute promyelocytic leukemia (APL) cell line	Lanotte et al., Blood 77: 1080 (1991)	Bone marrow	Female, 23	DSMZ	CVCL_0005 Cancer cell line
THP-1	Acute monocytic leukemia (AML) cell line	Tsuchiya et al., Int J Cancer 26: 171 (1980)	Peripheral blood	Male, 1	DSMZ	CVCL_0006 Cancer cell line
K-562	Chronic myeloid leukemia (CML) cell line	Lozzio et al., J Natl Cancer Inst 50: 535 (1973)	Pleural effusion	Female, 53	DSMZ	CVCL_0004 Cancer cell line
Mouse
NIH 3T3	Mouse embryonal fibroblast cell line	Aaronson et al., J Cell Physio 72(2): 141-148 (1968)	Embryo		DSMZ	CVCL_0594 Spontaneously immortalized cell line

Notes

Allen M, Bjerke M, Edlund H, Nelander S and Westermark B: Origin of the U87MG glioma cell line: Good news and bad news. Science Translational Medicine 31 Aug 2016: Vol. 8, Issue 354, pp. 354. DOI: 10.1126/scitranslmed.aaf6853

REH was previously listed as KM3. Due to misidentification, KM3 has been deleted from the DSMZ catalogue and the true identity is REH. DSMZ - False leukemia and lymphoma cell lines. Drexler et al., False leukemia-lymphoma cell lines: An update on over 500 cell lines. Leukemia 17: 416-426 (2003)

Source information

Prof. Bengt Westermark, Uppsala University, Uppsala, Sweden
Prof. Norbert E Fusenig, DKFZ, Heidelberg, Germany

Hematopoietic cell lines

Schematic description of hematopoietic differentiation lineages, and cellular origin for hematopoietic cell lines.

Cell lines

Brain

Eye

Proximal digestive tract

Gastrointestinal tract

Liver & Gallbladder

Kidney & Urinary bladder

Male reproductive system

Skin

Lung

Female reproductive system

Endothelial

Mesenchymal

Lymphoid

Myeloid

Mouse

Notes

Source information

Hematopoietic cell lines