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The search result lists the genes found by the search function.
The show/hide columns function can be used to customize the columns in the search result list.
To refine the search results with specific criterias, use the "Fields". For more information and examples see the Search help.
Data for all genes included in the search result can be downloaded in different formats, links are found in the upper right corner of the search result page: XML - An XML-file with more extensive data (including antigen sequences, protein expression, transcriptomics data, external references and more (see XSD)) for up to 10000 genes. RDF - Structured nanopublication data for the tissue annotations TSV - Tab-separated file with a subset of the data available in the XML-file JSON - JSON formatted file with the same subset of the data available in the TSV-file Custom - Custom dataset defined by the user in TSV or JSON format. Useful if you only need some of the data columns available in the TSV/JSON format
1. Select data columns:i
Change the selections below to determine which columns to have in the final file. The ensembl gene id is always added to have a identifier present in the output.
A whole group can be selected/unselected as well as individual data columns by toggling the checkboxes.
This paragraph provides an overview of proteins elevated in brain from a whole body perspective and proteins elevated in regions of the brain from a whole brain perspective.
Protein classi
Protein class(es) of the gene product according to selected gene lists. List of protein classes.
Biological processi
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Molecular functioni
Keywords assigned by UniProt to proteins due to their particular molecular function.
Disease involvementi
Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Antibodies used for immunohistochemistry (results presented in Tissue, Pathology and Brain Atlas) and immunocytochemistry/IF (results presented in Cell Atlas) assays. The assays are described in detail in Assays & annotation.
Reliability (IH)i
Reliability score, divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Reliability (Mouse Brain)i
Reliability score, divided into Supported or Uncertain, is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein/RNA/gene characterization data.
Reliability (IF)i
Reliability score, divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in cell lines and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are:
secreted into blood
locally secreted in a tissue or from a cell type
or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.
Cell Cycle Dependent Proteini
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Cell Cycle Dependent Transcripti
Cell cycle dependency of RNA expression in the FUCCI u-2 OS cell line, determined by RNA sequencing and monitoring of cell cycle stage in single cells. Genes encoding assayed transcripts are classified as CCD transcript "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Blood expression cluster
Tissue expression cluster
Brain expression cluster
Cell line expression cluster
Single cell expression cluster
Num protein interactions
Subcellular main location
Subcellular additional location
Antibody RRIDi
All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are:
secreted into blood
locally secreted in a tissue or from a cell type
or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Cervical canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Colorectal canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Endometrial canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Gliomai
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Head and neck canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Liver canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Lung canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Melanomai
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Ovarian canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Pancreatic canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Prostate canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Renal canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Stomach canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Testis canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Thyroid canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Urothelial canceri
Cell cycle dependency of protein expression in the FUCCI U-2 OS cell line, determined by ICC-IF and monitoring of cell cycle stage in single cells. Genes encoding assayed proteins are classified as CCD protein "Yes" or "No", while a lack of classification indicates that data on cell cycle dependency is lacking.
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Bile duct cancer (7 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Bladder cancer (26 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Bone cancer (21 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Brain cancer (80 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Breast cancer (62 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Cervical cancer (8 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Colorectal cancer (63 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Esophageal cancer (27 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Gallbladder cancer (1 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Gastric cancer (42 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Head and neck cancer (38 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Kidney cancer (35 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Leukemia (93 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Liver cancer (24 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Lung cancer (232 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Lymphoma (76 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Myeloma (34 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Neuroblastoma (17 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Non-cancerous (63 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Ovarian cancer (59 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Pancreatic cancer (46 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Prostate cancer (8 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Rhabdoid (14 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Sarcoma (15 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Skin cancer (62 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Testis cancer (1 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Thyroid cancer (11 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Uncategorized (11 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
Uterine cancer (29 cell lines) [nTPM]i
Normalized gene expression ("nTPM") for each cell line in primary cancer group. All cell lines included are listed here.
2. Select format to download:i
Selecting of format.
Clicking one of the Downlod boxes will download a file in the corresponding format with the selected data columns for the genes shown in the search result.
The copy boxes will give you a link to the file if you want to share it or save for later as a reference.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
x
Tissuei
The Tissue section contains information regarding the expression profile of human gene both on the mRNA and protein level. The protein expression data from 44 normal tissue types are derived from antibody-based profiling using immunohistchemistry. The green piechart indicates the level of reliability of the analyzed protein expression pattern based on available RNA-seq data, protein/gene characterization and immunohistochemical data from one or several antibodies with non-overlapping epitopes.
Braini
The Brain section describes gene expression in various regions of the human, mouse and pig brain, both on the mRNA and protein level.
Single celli
The Single Cell Type section describes RNA expression in single cell types based on scRNAseq from human tissues. Transcriptomics analysis of human blood and cultured cell lines are also presented.
Tissue celli
The tissue cell type section describes the cell type specificity profile of each gene within a given tissue based on an integrative co-expression analysis of bulk RNAseq data.
Pathologyi
The Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human genes in cancer tissue and the clinical outcome for almost 8000 cancer patients is presented in a gene-centric manner. The green piechart indicates the level of reliability of the analyzed protein expression pattern based on available RNA-seq data, protein/gene characterization and immunohistochemical data from one or several antibodies with non-overlapping epitopes.
Diseasei
The Human Disease Blood Atlas contains information on the protein levels in blood in patients with different diseases, as well as, the panels of proteins associated with the diseases according to AI-based prediction models.
Immunei
The Immune cell section contains single cell type mRNA expression data for human protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes.
Bloodi
The Blood Protein section presents estimated plasma concentrations of the proteins detected in human blood from mass spectrometry-based proteomics studies, published immune assay data and a longitudinal study based on proximity extension assay (PEA). Analysis of the human secretome (including annotation of genes predicted to be actively secreted to human blood) is also presented.
Subcelli
The Subcellular section contains high-resolution images showing the subcellular distribution of proteins and the RNA sequencing data of various tissue culture cell lines. The green piechart indicates the level of reliability of the detection protein localization based on available protein/gene characterization data and antibody validation level.
Cell linei
The Cell line section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines.
Structurei
The Structure section contains information on the available predicted and experimental protein structures for the majority of the genes, with the possibility to display related antigen sequences, and population and clinical variants.
Interactioni
The Interaction section enables exploration of protein interactions and metabolic networks.
The Human Protein Atlas project is funded
