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Pax6 is a transcription factor with a key regulatory role in eye and brain development. Within the mouse brain, both transcriptomic and proteomic databases show high expression in olfactory areas, where it is involved in the development of cell that process smell. However, in both human and mouse brain, PAX6 is predominantly seen in cerebellum, with a distinct distribution in cells of the granular layer.
In the current immunostaining, strong neuronal nuclear staining is noticed, which is highly restricted to a limited brain areas/nuclei:
In the olfactory bulb: granular and glomerular layers;
In the forebrain: lateral septum, piriform cortex, hypothalamic paraventricular nucleus, multiple amygdala nuclei, zona incerta, lateral hypothalamus, habenulae, caudal part of the hippocampus, entorhinal cortex;
In the brainstem: periaqueductal gray matter, dorsal raphe and raphe magnus, vestibular nucelus;
In the cerebellum: the staining is highly abundant in the cerebellar molecular layer.
In addition, very rare, sparse immunoreactive nuclei are noticed throughout the entire brain.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
Nucleus in neurons. Ventricle wall and circumventricular organs of ependymal cells.
The Human Protein Atlas project is funded
