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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.2
Chromosome location (bp)
99710868 - 99732127
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May be involved in the biosynthesis of heme A....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q7KZN9 [Direct mapping] Cytochrome c oxidase assembly protein COX15 homolog
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Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004129[cytochrome-c oxidase activity] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005746[mitochondrial respirasome] GO:0006123[mitochondrial electron transport, cytochrome c to oxygen] GO:0006783[heme biosynthetic process] GO:0006784[heme A biosynthetic process] GO:0007585[respiratory gaseous exchange by respiratory system] GO:0008535[respiratory chain complex IV assembly] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0016653[oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor] GO:0020037[heme binding] GO:0031966[mitochondrial membrane] GO:0045333[cellular respiration] GO:0060090[molecular adaptor activity] GO:0070069[cytochrome complex] GO:1902600[proton transmembrane transport]
Q7KZN9 [Direct mapping] Cytochrome c oxidase assembly protein COX15 homolog
Show all
Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004129[cytochrome-c oxidase activity] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005746[mitochondrial respirasome] GO:0006123[mitochondrial electron transport, cytochrome c to oxygen] GO:0006783[heme biosynthetic process] GO:0006784[heme A biosynthetic process] GO:0007585[respiratory gaseous exchange by respiratory system] GO:0008535[respiratory chain complex IV assembly] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0016653[oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor] GO:0020037[heme binding] GO:0031966[mitochondrial membrane] GO:0045333[cellular respiration] GO:0060090[molecular adaptor activity] GO:0070069[cytochrome complex] GO:1902600[proton transmembrane transport]
The Human Protein Atlas project is funded
