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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q21.11
Chromosome location (bp)
81699010 - 81770438
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor, Serine protease homolog
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0000902[cell morphogenesis] GO:0001837[epithelial to mesenchymal transition] GO:0001889[liver development] GO:0001934[positive regulation of protein phosphorylation] GO:0004252[serine-type endopeptidase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006508[proteolysis] GO:0008083[growth factor activity] GO:0010507[negative regulation of autophagy] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014856[skeletal muscle cell proliferation] GO:0016020[membrane] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0031100[animal organ regeneration] GO:0031643[positive regulation of myelination] GO:0032715[negative regulation of interleukin-6 production] GO:0032733[positive regulation of interleukin-10 production] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043410[positive regulation of MAPK cascade] GO:0044877[protein-containing complex binding] GO:0045669[positive regulation of osteoblast differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0050673[epithelial cell proliferation] GO:0050728[negative regulation of inflammatory response] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0051450[myoblast proliferation] GO:0060326[cell chemotaxis] GO:0060665[regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0070572[positive regulation of neuron projection regeneration] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1900744[regulation of p38MAPK cascade] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902947[regulation of tau-protein kinase activity] GO:2000573[positive regulation of DNA biosynthetic process]
Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0001837[epithelial to mesenchymal transition] GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008083[growth factor activity] GO:0010507[negative regulation of autophagy] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0060326[cell chemotaxis] GO:0060665[regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:2000573[positive regulation of DNA biosynthetic process]
Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278[mitotic cell cycle] GO:0001837[epithelial to mesenchymal transition] GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008083[growth factor activity] GO:0010507[negative regulation of autophagy] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0060326[cell chemotaxis] GO:0060665[regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:2000573[positive regulation of DNA biosynthetic process]
Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0001837[epithelial to mesenchymal transition] GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008083[growth factor activity] GO:0010507[negative regulation of autophagy] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0060326[cell chemotaxis] GO:0060665[regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:2000573[positive regulation of DNA biosynthetic process]
Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the digestive system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278[mitotic cell cycle] GO:0001837[epithelial to mesenchymal transition] GO:0001934[positive regulation of protein phosphorylation] GO:0004252[serine-type endopeptidase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006508[proteolysis] GO:0008083[growth factor activity] GO:0010507[negative regulation of autophagy] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045669[positive regulation of osteoblast differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0060326[cell chemotaxis] GO:0060665[regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:2000573[positive regulation of DNA biosynthetic process]
The Human Protein Atlas project is funded
