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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes CD markers Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.22
Chromosome location (bp)
12166991 - 12209228
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P20333 [Direct mapping] Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor receptor superfamily member 1b, membrane form Tumor necrosis factor-binding protein 2
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002718[regulation of cytokine production involved in immune response] GO:0002724[regulation of T cell cytokine production] GO:0002947[tumor necrosis factor receptor superfamily complex] GO:0003176[aortic valve development] GO:0003177[pulmonary valve development] GO:0003332[negative regulation of extracellular matrix constituent secretion] GO:0005031[tumor necrosis factor receptor activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007166[cell surface receptor signaling pathway] GO:0007568[aging] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010614[negative regulation of cardiac muscle hypertrophy] GO:0016020[membrane] GO:0030424[axon] GO:0031625[ubiquitin protein ligase binding] GO:0031641[regulation of myelination] GO:0031643[positive regulation of myelination] GO:0032496[response to lipopolysaccharide] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035579[specific granule membrane] GO:0042129[regulation of T cell proliferation] GO:0043025[neuronal cell body] GO:0043120[tumor necrosis factor binding] GO:0043196[varicosity] GO:0045121[membrane raft] GO:0048471[perinuclear region of cytoplasm] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0050728[negative regulation of inflammatory response] GO:0050779[RNA destabilization] GO:0051044[positive regulation of membrane protein ectodomain proteolysis] GO:0060548[negative regulation of cell death] GO:0071222[cellular response to lipopolysaccharide] GO:0071356[cellular response to tumor necrosis factor] GO:0071363[cellular response to growth factor stimulus] GO:0097191[extrinsic apoptotic signaling pathway] GO:0150077[regulation of neuroinflammatory response] GO:0150079[negative regulation of neuroinflammatory response] GO:0150098[glial cell-neuron signaling] GO:1901215[negative regulation of neuron death] GO:1902339[positive regulation of apoptotic process involved in morphogenesis] GO:2001141[regulation of RNA biosynthetic process]
The Human Protein Atlas project is funded
