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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q33.3
Chromosome location (bp)
125234853 - 125241382
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen 1,2,3,4. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) 5,6. In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone, Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
V9HWB4 [Target identity:100%; Query identity:100%] 78 kDa glucose-regulated protein
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Enzymes ENZYME proteins Hydrolases Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001554[luteolysis] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005789[endoplasmic reticulum membrane] GO:0005790[smooth endoplasmic reticulum] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006983[ER overload response] GO:0008180[COP9 signalosome] GO:0009314[response to radiation] GO:0009986[cell surface] GO:0010976[positive regulation of neuron projection development] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0021589[cerebellum structural organization] GO:0021680[cerebellar Purkinje cell layer development] GO:0021762[substantia nigra development] GO:0030182[neuron differentiation] GO:0030335[positive regulation of cell migration] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0030496[midbody] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0031072[heat shock protein binding] GO:0031204[post-translational protein targeting to membrane, translocation] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031398[positive regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034620[cellular response to unfolded protein] GO:0034663[endoplasmic reticulum chaperone complex] GO:0034975[protein folding in endoplasmic reticulum] GO:0034976[response to endoplasmic reticulum stress] GO:0035437[maintenance of protein localization in endoplasmic reticulum] GO:0042026[protein refolding] GO:0042149[cellular response to glucose starvation] GO:0042220[response to cocaine] GO:0042470[melanosome] GO:0043022[ribosome binding] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0044183[protein folding chaperone] GO:0045296[cadherin binding] GO:0051082[unfolded protein binding] GO:0051085[chaperone cofactor-dependent protein refolding] GO:0051087[chaperone binding] GO:0051402[neuron apoptotic process] GO:0051603[proteolysis involved in protein catabolic process] GO:0051787[misfolded protein binding] GO:0060904[regulation of protein folding in endoplasmic reticulum] GO:0070062[extracellular exosome] GO:0071236[cellular response to antibiotic] GO:0071277[cellular response to calcium ion] GO:0071287[cellular response to manganese ion] GO:0071320[cellular response to cAMP] GO:0071353[cellular response to interleukin-4] GO:0071466[cellular response to xenobiotic stimulus] GO:0071480[cellular response to gamma radiation] GO:0097501[stress response to metal ion] GO:0140662[ATP-dependent protein folding chaperone] GO:1901998[toxin transport] GO:1903891[regulation of ATF6-mediated unfolded protein response] GO:1903894[regulation of IRE1-mediated unfolded protein response] GO:1903895[negative regulation of IRE1-mediated unfolded protein response] GO:1903897[regulation of PERK-mediated unfolded protein response] GO:1904313[response to methamphetamine hydrochloride] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
The Human Protein Atlas project is funded
