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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Ras protein specific guanine nucleotide releasing factor 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q25.1
Chromosome location (bp)
78959906 - 79090780
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes the exchange of Ras-bound GDP by GTP....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007616[long-term memory] GO:0030426[growth cone] GO:0031175[neuron projection development] GO:0034976[response to endoplasmic reticulum stress] GO:0035020[regulation of Rac protein signal transduction] GO:0035023[regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0043547[positive regulation of GTPase activity] GO:0046578[regulation of Ras protein signal transduction] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048167[regulation of synaptic plasticity] GO:0090630[activation of GTPase activity]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007616[long-term memory] GO:0030426[growth cone] GO:0031175[neuron projection development] GO:0034976[response to endoplasmic reticulum stress] GO:0035020[regulation of Rac protein signal transduction] GO:0035023[regulation of Rho protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0043547[positive regulation of GTPase activity] GO:0046578[regulation of Ras protein signal transduction] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048167[regulation of synaptic plasticity] GO:0090630[activation of GTPase activity]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0007616[long-term memory] GO:0030426[growth cone] GO:0031175[neuron projection development] GO:0034976[response to endoplasmic reticulum stress] GO:0035020[regulation of Rac protein signal transduction] GO:0035023[regulation of Rho protein signal transduction] GO:0035254[glutamate receptor binding] GO:0035556[intracellular signal transduction] GO:0043005[neuron projection] GO:0043547[positive regulation of GTPase activity] GO:0044342[type B pancreatic cell proliferation] GO:0046578[regulation of Ras protein signal transduction] GO:0046579[positive regulation of Ras protein signal transduction] GO:0048167[regulation of synaptic plasticity] GO:0048168[regulation of neuronal synaptic plasticity] GO:0090630[activation of GTPase activity] GO:2000310[regulation of NMDA receptor activity]
The Human Protein Atlas project is funded
