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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p13
Chromosome location (bp)
41359607 - 41700044
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with myosin II complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
Q9UPQ0 [Direct mapping] LIM and calponin homology domains-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725[stress fiber] GO:0001934[positive regulation of protein phosphorylation] GO:0003779[actin binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0016460[myosin II complex] GO:0030336[negative regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032034[myosin II head/neck binding] GO:0046872[metal ion binding] GO:0051496[positive regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0060327[cytoplasmic actin-based contraction involved in cell motility]
The Human Protein Atlas project is funded
