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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.33
Chromosome location (bp)
2050411 - 2185395
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q05513 [Direct mapping] Protein kinase C zeta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000226[microtubule cytoskeleton organization] GO:0001725[stress fiber] GO:0001954[positive regulation of cell-matrix adhesion] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005635[nuclear envelope] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005923[bicellular tight junction] GO:0005938[cell cortex] GO:0006468[protein phosphorylation] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007616[long-term memory] GO:0008104[protein localization] GO:0008284[positive regulation of cell population proliferation] GO:0014069[postsynaptic density] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016324[apical plasma membrane] GO:0016363[nuclear matrix] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0030010[establishment of cell polarity] GO:0030054[cell junction] GO:0031252[cell leading edge] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031584[activation of phospholipase D activity] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032733[positive regulation of interleukin-10 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032754[positive regulation of interleukin-5 production] GO:0032869[cellular response to insulin stimulus] GO:0035556[intracellular signal transduction] GO:0035748[myelin sheath abaxonal region] GO:0043066[negative regulation of apoptotic process] GO:0043203[axon hillock] GO:0043231[intracellular membrane-bounded organelle] GO:0043274[phospholipase binding] GO:0043560[insulin receptor substrate binding] GO:0044877[protein-containing complex binding] GO:0045121[membrane raft] GO:0045179[apical cortex] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045630[positive regulation of T-helper 2 cell differentiation] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0047496[vesicle transport along microtubule] GO:0048471[perinuclear region of cytoplasm] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050806[positive regulation of synaptic transmission] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051222[positive regulation of protein transport] GO:0051346[negative regulation of hydrolase activity] GO:0051899[membrane depolarization] GO:0060081[membrane hyperpolarization] GO:0060291[long-term synaptic potentiation] GO:0070062[extracellular exosome] GO:0070160[tight junction] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070528[protein kinase C signaling] GO:0071889[14-3-3 protein binding] GO:0072659[protein localization to plasma membrane] GO:0098685[Schaffer collateral - CA1 synapse] GO:0098696[regulation of neurotransmitter receptor localization to postsynaptic specialization membrane] GO:0098978[glutamatergic synapse] GO:0106310[protein serine kinase activity] GO:0120157[PAR polarity complex] GO:1990138[neuron projection extension] GO:2000463[positive regulation of excitatory postsynaptic potential] GO:2000553[positive regulation of T-helper 2 cell cytokine production]
Q05513 [Direct mapping] Protein kinase C zeta type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0006468[protein phosphorylation] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030010[establishment of cell polarity] GO:0030054[cell junction] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031982[vesicle] GO:0032733[positive regulation of interleukin-10 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032754[positive regulation of interleukin-5 production] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043560[insulin receptor substrate binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045630[positive regulation of T-helper 2 cell differentiation] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060291[long-term synaptic potentiation] GO:0070062[extracellular exosome] GO:0070160[tight junction] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0106310[protein serine kinase activity] GO:0120157[PAR polarity complex] GO:2000463[positive regulation of excitatory postsynaptic potential] GO:2000553[positive regulation of T-helper 2 cell cytokine production]
Q05513 [Direct mapping] Protein kinase C zeta type
Show all
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0006468[protein phosphorylation] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0030010[establishment of cell polarity] GO:0030054[cell junction] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031982[vesicle] GO:0032733[positive regulation of interleukin-10 production] GO:0032736[positive regulation of interleukin-13 production] GO:0032753[positive regulation of interleukin-4 production] GO:0032754[positive regulation of interleukin-5 production] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043560[insulin receptor substrate binding] GO:0045197[establishment or maintenance of epithelial cell apical/basal polarity] GO:0045630[positive regulation of T-helper 2 cell differentiation] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060291[long-term synaptic potentiation] GO:0070062[extracellular exosome] GO:0070160[tight junction] GO:0070161[anchoring junction] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0106310[protein serine kinase activity] GO:0120157[PAR polarity complex] GO:2000463[positive regulation of excitatory postsynaptic potential] GO:2000553[positive regulation of T-helper 2 cell cytokine production]
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