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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q21.2
Chromosome location (bp)
78863993 - 79452008
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes 1....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome. [provided by RefSeq, Jan 2023]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0001786[phosphatidylserine binding] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005543[phospholipid binding] GO:0005544[calcium-dependent phospholipid binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0007268[chemical synaptic transmission] GO:0007269[neurotransmitter secretion] GO:0007420[brain development] GO:0008021[synaptic vesicle] GO:0008022[protein C-terminus binding] GO:0014059[regulation of dopamine secretion] GO:0016020[membrane] GO:0016079[synaptic vesicle exocytosis] GO:0016192[vesicle-mediated transport] GO:0017075[syntaxin-1 binding] GO:0017156[calcium-ion regulated exocytosis] GO:0017157[regulation of exocytosis] GO:0017158[regulation of calcium ion-dependent exocytosis] GO:0019905[syntaxin binding] GO:0030141[secretory granule] GO:0030154[cell differentiation] GO:0030276[clathrin binding] GO:0030348[syntaxin-3 binding] GO:0030424[axon] GO:0030658[transport vesicle membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030672[synaptic vesicle membrane] GO:0031045[dense core granule] GO:0031340[positive regulation of vesicle fusion] GO:0031410[cytoplasmic vesicle] GO:0033603[positive regulation of dopamine secretion] GO:0042584[chromaffin granule membrane] GO:0042734[presynaptic membrane] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043229[intracellular organelle] GO:0044306[neuron projection terminus] GO:0045202[synapse] GO:0045956[positive regulation of calcium ion-dependent exocytosis] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0048278[vesicle docking] GO:0048306[calcium-dependent protein binding] GO:0048488[synaptic vesicle endocytosis] GO:0048791[calcium ion-regulated exocytosis of neurotransmitter] GO:0050750[low-density lipoprotein particle receptor binding] GO:0050806[positive regulation of synaptic transmission] GO:0051291[protein heterooligomerization] GO:0051592[response to calcium ion] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0060076[excitatory synapse] GO:0060201[clathrin-sculpted acetylcholine transport vesicle membrane] GO:0060203[clathrin-sculpted glutamate transport vesicle membrane] GO:0061202[clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] GO:0061669[spontaneous neurotransmitter secretion] GO:0061891[calcium ion sensor activity] GO:0070083[clathrin-sculpted monoamine transport vesicle membrane] GO:0070382[exocytic vesicle] GO:0071277[cellular response to calcium ion] GO:0071911[synchronous neurotransmitter secretion] GO:0098686[hippocampal mossy fiber to CA3 synapse] GO:0098746[fast, calcium ion-dependent exocytosis of neurotransmitter] GO:0098978[glutamatergic synapse] GO:0099502[calcium-dependent activation of synaptic vesicle fusion] GO:1903235[positive regulation of calcium ion-dependent exocytosis of neurotransmitter] GO:1903305[regulation of regulated secretory pathway] GO:1903861[positive regulation of dendrite extension] GO:2000300[regulation of synaptic vesicle exocytosis]
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0001786[phosphatidylserine binding] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005544[calcium-dependent phospholipid binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007268[chemical synaptic transmission] GO:0007269[neurotransmitter secretion] GO:0008021[synaptic vesicle] GO:0014059[regulation of dopamine secretion] GO:0016020[membrane] GO:0016192[vesicle-mediated transport] GO:0017075[syntaxin-1 binding] GO:0017156[calcium-ion regulated exocytosis] GO:0017157[regulation of exocytosis] GO:0017158[regulation of calcium ion-dependent exocytosis] GO:0019905[syntaxin binding] GO:0030154[cell differentiation] GO:0030276[clathrin binding] GO:0030424[axon] GO:0030658[transport vesicle membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030672[synaptic vesicle membrane] GO:0031045[dense core granule] GO:0031410[cytoplasmic vesicle] GO:0042584[chromaffin granule membrane] GO:0043005[neuron projection] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0048488[synaptic vesicle endocytosis] GO:0048791[calcium ion-regulated exocytosis of neurotransmitter] GO:0050750[low-density lipoprotein particle receptor binding] GO:0050806[positive regulation of synaptic transmission] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0060201[clathrin-sculpted acetylcholine transport vesicle membrane] GO:0060203[clathrin-sculpted glutamate transport vesicle membrane] GO:0061202[clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] GO:0070083[clathrin-sculpted monoamine transport vesicle membrane] GO:0070382[exocytic vesicle] GO:0071277[cellular response to calcium ion] GO:0098746[fast, calcium ion-dependent exocytosis of neurotransmitter] GO:1903235[positive regulation of calcium ion-dependent exocytosis of neurotransmitter] GO:1903305[regulation of regulated secretory pathway] GO:1903861[positive regulation of dendrite extension]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149[SNARE binding] GO:0001786[phosphatidylserine binding] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005544[calcium-dependent phospholipid binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0007268[chemical synaptic transmission] GO:0007269[neurotransmitter secretion] GO:0008021[synaptic vesicle] GO:0014059[regulation of dopamine secretion] GO:0016020[membrane] GO:0016192[vesicle-mediated transport] GO:0017075[syntaxin-1 binding] GO:0017156[calcium-ion regulated exocytosis] GO:0017157[regulation of exocytosis] GO:0017158[regulation of calcium ion-dependent exocytosis] GO:0019905[syntaxin binding] GO:0030154[cell differentiation] GO:0030276[clathrin binding] GO:0030424[axon] GO:0030658[transport vesicle membrane] GO:0030669[clathrin-coated endocytic vesicle membrane] GO:0030672[synaptic vesicle membrane] GO:0031045[dense core granule] GO:0031410[cytoplasmic vesicle] GO:0042584[chromaffin granule membrane] GO:0043005[neuron projection] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0048488[synaptic vesicle endocytosis] GO:0048791[calcium ion-regulated exocytosis of neurotransmitter] GO:0050750[low-density lipoprotein particle receptor binding] GO:0050806[positive regulation of synaptic transmission] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0060201[clathrin-sculpted acetylcholine transport vesicle membrane] GO:0060203[clathrin-sculpted glutamate transport vesicle membrane] GO:0061202[clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] GO:0070083[clathrin-sculpted monoamine transport vesicle membrane] GO:0070382[exocytic vesicle] GO:0071277[cellular response to calcium ion] GO:0098746[fast, calcium ion-dependent exocytosis of neurotransmitter] GO:1903235[positive regulation of calcium ion-dependent exocytosis of neurotransmitter] GO:1903305[regulation of regulated secretory pathway] GO:1903861[positive regulation of dendrite extension]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
