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Galanin is a predominantly inhibitory neuropeptide that is widely expressed in the brain of mammals. Galanin RNA is highly enriched in the human pituitary gland while, within the mouse CNS, highest RNA and protein is found in the hypothalamus with lower but distinct levels in the brainstem and septum. In general, moderate to strong intensity immunostaining of dense axonal networks is noticed in multiple but distinct brain regions of the mouse brain. Strong intensity very dense axonal staining is observed in the BNST nuclei, anterior and tuberal hypothalamus, especially in the dorsomedial and arcuate nuclei, thalamic paraventricular nucleus, central amygdala, locus coeruleus and dorsal motor nucleus of the vagus. Moderate-intensity axonal staining is observed in the 'prefrontal' cortical areas, entorhinal cortex, hippocampus, ventral tegmental area, substantia nigra, periaqueductal gray matter, nucleus accumbens shell, lateral septum and ventral pallidum. In addition, strong intensity immunostaining of neuronal cell bodies is noticed in the central amygdala and the locus coeruleus while median eminence and area postrema are strongly immunoreactive too.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
Soma and axon in neurons. Circumventricular organs of ependymal cells.
The Human Protein Atlas project is funded
