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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q25.1
Chromosome location (bp)
149964904 - 150050788
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Actin-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003779[actin binding] GO:0003785[actin monomer binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0010633[negative regulation of epithelial cell migration] GO:0016043[cellular component organization] GO:0016887[ATP hydrolysis activity] GO:0030036[actin cytoskeleton organization] GO:0030833[regulation of actin filament polymerization] GO:0030837[negative regulation of actin filament polymerization] GO:0030838[positive regulation of actin filament polymerization] GO:0032233[positive regulation of actin filament bundle assembly] GO:0032781[positive regulation of ATP-dependent activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0044087[regulation of cellular component biogenesis] GO:0050804[modulation of chemical synaptic transmission] GO:0050821[protein stabilization] GO:0051496[positive regulation of stress fiber assembly] GO:0070062[extracellular exosome] GO:0098685[Schaffer collateral - CA1 synapse] GO:0098793[presynapse] GO:0098794[postsynapse] GO:0098885[modification of postsynaptic actin cytoskeleton] GO:0098978[glutamatergic synapse] GO:0099171[presynaptic modulation of chemical synaptic transmission] GO:0110053[regulation of actin filament organization] GO:1900028[negative regulation of ruffle assembly] GO:2000300[regulation of synaptic vesicle exocytosis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003779[actin binding] GO:0003785[actin monomer binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0010633[negative regulation of epithelial cell migration] GO:0016043[cellular component organization] GO:0016887[ATP hydrolysis activity] GO:0030036[actin cytoskeleton organization] GO:0030833[regulation of actin filament polymerization] GO:0030837[negative regulation of actin filament polymerization] GO:0030838[positive regulation of actin filament polymerization] GO:0032233[positive regulation of actin filament bundle assembly] GO:0032781[positive regulation of ATP-dependent activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0044087[regulation of cellular component biogenesis] GO:0050821[protein stabilization] GO:0051496[positive regulation of stress fiber assembly] GO:0070062[extracellular exosome] GO:0110053[regulation of actin filament organization] GO:1900028[negative regulation of ruffle assembly]
The Human Protein Atlas project is funded
