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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Protein kinase cAMP-activated catalytic subunit alpha
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.12
Chromosome location (bp)
14091688 - 14118084
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Phosphorylates a large number of substrates in the cytoplasm and the nucleus 1,2,3,4,5,6,7,8,9,10,11,12. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP 13,14,15,16,17,18,19,20,21,22,23,24. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis 25. RORA is activated by phosphorylation 26. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts 27. Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP 28,29. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated 30. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) 31. PSMC5/RPT6 activation by phosphorylation stimulates proteasome 32. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation 33. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding 34. Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis 35. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA 36,37. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock 38....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, cAMP, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P17612 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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A0A024R7J0 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0001669[acrosomal vesicle] GO:0001707[mesoderm formation] GO:0001843[neural tube closure] GO:0002027[regulation of heart rate] GO:0003091[renal water homeostasis] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004679[AMP-activated protein kinase activity] GO:0004691[cAMP-dependent protein kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005929[cilium] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006397[mRNA processing] GO:0006468[protein phosphorylation] GO:0006611[protein export from nucleus] GO:0007189[adenylate cyclase-activating G protein-coupled receptor signaling pathway] GO:0010737[protein kinase A signaling] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016241[regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0019904[protein domain specific binding] GO:0030145[manganese ion binding] GO:0031410[cytoplasmic vesicle] GO:0031514[motile cilium] GO:0031588[nucleotide-activated protein kinase complex] GO:0031594[neuromuscular junction] GO:0031625[ubiquitin protein ligase binding] GO:0032024[positive regulation of insulin secretion] GO:0034237[protein kinase A regulatory subunit binding] GO:0034380[high-density lipoprotein particle assembly] GO:0034605[cellular response to heat] GO:0034704[calcium channel complex] GO:0035584[calcium-mediated signaling using intracellular calcium source] GO:0036126[sperm flagellum] GO:0042995[cell projection] GO:0043197[dendritic spine] GO:0043393[regulation of protein binding] GO:0044853[plasma membrane raft] GO:0045667[regulation of osteoblast differentiation] GO:0046777[protein autophosphorylation] GO:0046827[positive regulation of protein export from nucleus] GO:0048240[sperm capacitation] GO:0048471[perinuclear region of cytoplasm] GO:0050804[modulation of chemical synaptic transmission] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0051726[regulation of cell cycle] GO:0055117[regulation of cardiac muscle contraction] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0061136[regulation of proteasomal protein catabolic process] GO:0070062[extracellular exosome] GO:0070417[cellular response to cold] GO:0070613[regulation of protein processing] GO:0071333[cellular response to glucose stimulus] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:0097546[ciliary base] GO:0098978[glutamatergic synapse] GO:0099170[postsynaptic modulation of chemical synaptic transmission] GO:0106310[protein serine kinase activity] GO:1901621[negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] GO:1903779[regulation of cardiac conduction] GO:1990044[protein localization to lipid droplet] GO:2000810[regulation of bicellular tight junction assembly]
B7Z708 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha; cDNA FLJ58698, highly similar to cAMP-dependent protein kinase, alpha-catalytic subunit
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Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
K7EMV1 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
P17612 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001669[acrosomal vesicle] GO:0002027[regulation of heart rate] GO:0003091[renal water homeostasis] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004679[AMP-activated protein kinase activity] GO:0004691[cAMP-dependent protein kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005929[cilium] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006397[mRNA processing] GO:0006468[protein phosphorylation] GO:0010737[protein kinase A signaling] GO:0010881[regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020[membrane] GO:0016241[regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016607[nuclear speck] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0031410[cytoplasmic vesicle] GO:0031514[motile cilium] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0034237[protein kinase A regulatory subunit binding] GO:0034380[high-density lipoprotein particle assembly] GO:0034605[cellular response to heat] GO:0034704[calcium channel complex] GO:0035584[calcium-mediated signaling using intracellular calcium source] GO:0042995[cell projection] GO:0043393[regulation of protein binding] GO:0044853[plasma membrane raft] GO:0045667[regulation of osteoblast differentiation] GO:0048240[sperm capacitation] GO:0048471[perinuclear region of cytoplasm] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0051726[regulation of cell cycle] GO:0055117[regulation of cardiac muscle contraction] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0061136[regulation of proteasomal protein catabolic process] GO:0070062[extracellular exosome] GO:0071333[cellular response to glucose stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:0097225[sperm midpiece] GO:0097546[ciliary base] GO:0106310[protein serine kinase activity] GO:1903779[regulation of cardiac conduction] GO:2000810[regulation of bicellular tight junction assembly]
K7ENJ5 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
Q15136 [Direct mapping] Protein kinase A-alpha; cAMP-dependent protein kinase catalytic subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
