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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q21.11
Chromosome location (bp)
83955777 - 84492724
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001755[neural crest cell migration] GO:0001764[neuron migration] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0007399[nervous system development] GO:0007411[axon guidance] GO:0008045[motor neuron axon guidance] GO:0010977[negative regulation of neuron projection development] GO:0021675[nerve development] GO:0021772[olfactory bulb development] GO:0030154[cell differentiation] GO:0030215[semaphorin receptor binding] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0030425[dendrite] GO:0030517[negative regulation of axon extension] GO:0038191[neuropilin binding] GO:0045499[chemorepellent activity] GO:0046330[positive regulation of JNK cascade] GO:0048485[sympathetic nervous system development] GO:0048841[regulation of axon extension involved in axon guidance] GO:0048843[negative regulation of axon extension involved in axon guidance] GO:0048846[axon extension involved in axon guidance] GO:0048880[sensory system development] GO:0050919[negative chemotaxis] GO:0060385[axonogenesis involved in innervation] GO:0061549[sympathetic ganglion development] GO:0071526[semaphorin-plexin signaling pathway] GO:0097490[sympathetic neuron projection extension] GO:0097491[sympathetic neuron projection guidance] GO:0150020[basal dendrite arborization] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1902285[semaphorin-plexin signaling pathway involved in neuron projection guidance] GO:2001224[positive regulation of neuron migration]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001755[neural crest cell migration] GO:0001764[neuron migration] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0007399[nervous system development] GO:0007411[axon guidance] GO:0008045[motor neuron axon guidance] GO:0010977[negative regulation of neuron projection development] GO:0021675[nerve development] GO:0021772[olfactory bulb development] GO:0030154[cell differentiation] GO:0030215[semaphorin receptor binding] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0038191[neuropilin binding] GO:0045499[chemorepellent activity] GO:0046330[positive regulation of JNK cascade] GO:0048485[sympathetic nervous system development] GO:0048841[regulation of axon extension involved in axon guidance] GO:0048843[negative regulation of axon extension involved in axon guidance] GO:0048846[axon extension involved in axon guidance] GO:0048880[sensory system development] GO:0050919[negative chemotaxis] GO:0060385[axonogenesis involved in innervation] GO:0061549[sympathetic ganglion development] GO:0071526[semaphorin-plexin signaling pathway] GO:0097490[sympathetic neuron projection extension] GO:0097491[sympathetic neuron projection guidance] GO:0150020[basal dendrite arborization] GO:1901166[neural crest cell migration involved in autonomic nervous system development] GO:1902285[semaphorin-plexin signaling pathway involved in neuron projection guidance] GO:2001224[positive regulation of neuron migration]
The Human Protein Atlas project is funded
