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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q21.11
Chromosome location (bp)
80742538 - 80922359
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001755[neural crest cell migration] GO:0001756[somitogenesis] GO:0001974[blood vessel remodeling] GO:0003148[outflow tract septum morphogenesis] GO:0003151[outflow tract morphogenesis] GO:0003215[cardiac right ventricle morphogenesis] GO:0003350[pulmonary myocardium development] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0007399[nervous system development] GO:0007411[axon guidance] GO:0007507[heart development] GO:0009410[response to xenobiotic stimulus] GO:0009791[post-embryonic development] GO:0021915[neural tube development] GO:0030154[cell differentiation] GO:0030215[semaphorin receptor binding] GO:0030335[positive regulation of cell migration] GO:0045499[chemorepellent activity] GO:0048843[negative regulation of axon extension involved in axon guidance] GO:0050919[negative chemotaxis] GO:0060174[limb bud formation] GO:0060666[dichotomous subdivision of terminal units involved in salivary gland branching] GO:0070062[extracellular exosome] GO:0071526[semaphorin-plexin signaling pathway] GO:0140074[cardiac endothelial to mesenchymal transition] GO:1905312[positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis]
The Human Protein Atlas project is funded
