Expression of ACTB in testis cancer - The Human Protein Atlas

TESTIS CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

ACTB is not prognostic in testis cancer

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1808.93

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1806.2

Number of samples

134

Samples

Sample	Description	FPKM
TCGA-2G-AAGV-01A	23 years, male, white, alive, 4527 days	3319.4
TCGA-ZM-AA0N-01A	44 years, male, white, stage:ib, alive, 634 days	3198.9
TCGA-VF-A8AE-01A	39 years, male, white, stage:ia, alive, 727 days	2918.5
TCGA-ZM-AA0D-01A	34 years, male, white, stage:ia, alive, 848 days	2808.7
TCGA-2G-AALP-01A	43 years, male, white, stage:iiib, alive, 2645 days	2780.3
TCGA-YU-A90S-01A	26 years, male, white, stage:ia, alive, 971 days	2745.2
TCGA-VF-A8A9-01A	31 years, male, white, stage:ia, alive, 1119 days	2656.4
TCGA-4K-AA1H-01A	26 years, male, white, stage:ia, alive, 518 days	2623.1
TCGA-2G-AAGT-01A	30 years, male, white, stage:is, alive, 4406 days	2574.3
TCGA-2G-AAFM-01A	31 years, male, white, stage:iia, alive, 503 days	2570.7
TCGA-2G-AAKG-01A	22 years, male, white, stage:i, alive, 6598 days	2538.2
TCGA-XE-AAOB-01A	27 years, male, white, stage:is, dead, 513 days	2515.7
TCGA-2G-AAFY-01A	24 years, male, white, stage:iia, alive, 1099 days	2505.3
TCGA-2G-AAL7-01A	32 years, male, white, stage:is, alive, 3991 days	2492.7
TCGA-2G-AAFN-01A	26 years, male, white, stage:iiib, alive, 773 days	2448.2
TCGA-XE-AAOJ-01A	24 years, male, white, stage:is, alive, 1550 days	2432.9
TCGA-4K-AA1I-01A	26 years, male, white, stage:ia, alive, 3 days	2430.7
TCGA-2G-AAG7-01A	33 years, male, white, stage:is, alive, 2475 days	2373.6
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:iiic, alive, 1573 days	2355.4
TCGA-2G-AAHN-01A	32 years, male, white, stage:i, alive, 6445 days	2349.1
TCGA-2G-AAG8-01A	21 years, male, white, stage:ib, alive, 2289 days	2340.3
TCGA-2G-AAG0-01A	23 years, male, white, stage:is, alive, 1529 days	2339.9
TCGA-ZM-AA0B-01A	32 years, male, white, stage:ia, alive, 838 days	2317.4
TCGA-VF-A8A8-01A	18 years, male, white, stage:ia, alive, 1131 days	2312.7
TCGA-ZM-AA0F-01A	35 years, male, white, stage:ia, alive, 681 days	2294.2
TCGA-2G-AAHL-01A	26 years, male, white, stage:i, alive, 7081 days	2270.9
TCGA-2G-AAGN-01A	41 years, male, white, stage:iiib, alive, 3656 days	2263.7
TCGA-2G-AAGK-01A	20 years, male, white, stage:is, alive, 3621 days	2262.4
TCGA-VF-A8AD-01A	36 years, male, white, stage:ib, alive, 1006 days	2248.5
TCGA-XY-A8S2-01A	67 years, male, white, stage:i, alive, 672 days	2241.9
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:ia, alive, 760 days	2217.8
TCGA-2G-AAGF-01A	28 years, male, white, stage:is, alive, 2734 days	2169.8
TCGA-XY-A8S3-01B	24 years, male, white, stage:is, alive, 843 days	2140.5
TCGA-X3-A8G4-01A	33 years, male, white, stage:is, alive, 856 days	2140.1
TCGA-2G-AAGZ-01A	27 years, male, white, stage:iiia, alive, 5233 days	2135.3
TCGA-ZM-AA0H-01A	50 years, male, white, stage:is, alive, 1736 days	2124.1
TCGA-ZM-AA0E-01A	39 years, male, white, stage:ia, alive, 811 days	2121.4
TCGA-2G-AAGP-01A	33 years, male, white, stage:iia, alive, 4018 days	2116.9
TCGA-W4-A7U4-01A	23 years, male, white, alive, 738 days	2109.6
TCGA-2G-AAGS-01A	39 years, male, white, stage:iiib, alive, 4816 days	2074.9
TCGA-2G-AAFG-01A	30 years, male, white, stage:is, alive, 6183 days	2073.6
TCGA-XE-AAOF-01A	50 years, male, asian, stage:ia, alive, 1268 days	2046.5
TCGA-ZM-AA05-01A	36 years, male, white, stage:iic, alive, 1126 days	2034.2
TCGA-2G-AAFO-01A	33 years, male, white, stage:iia, alive, 685 days	2031.1
TCGA-2G-AAHA-01A	48 years, male, white, stage:ib, alive, 3349 days	2008.2
TCGA-VF-A8AC-01A	29 years, male, white, stage:ia, alive, 1083 days	2000.9
TCGA-2G-AAKL-01A	26 years, male, white, stage:ii, alive, 7023 days	1982.0
TCGA-WZ-A8D5-01A	38 years, male, white, alive, 774 days	1965.1
TCGA-2G-AAKD-01A	18 years, male, white, stage:iii, alive, 6340 days	1954.1
TCGA-2G-AAHC-01A	33 years, male, white, stage:is, alive, 5539 days	1905.2
TCGA-2G-AAGW-01A	38 years, male, white, stage:is, alive, 4899 days	1893.7
TCGA-SN-A84Y-01A	18 years, male, white, stage:is, alive, 524 days	1887.4
TCGA-2G-AAG6-01A	24 years, male, white, stage:is, alive, 2231 days	1862.8
TCGA-2G-AAFL-01A	35 years, male, white, stage:ib, alive, 750 days	1860.3
TCGA-2G-AAKH-01A	19 years, male, white, stage:ii, alive, 6862 days	1854.0
TCGA-YU-AA61-01A	29 years, male, white, stage:is, alive, 864 days	1852.8
TCGA-2G-AAFV-01A	31 years, male, white, stage:is, alive, 1389 days	1847.8
TCGA-YU-A90P-01A	25 years, male, white, stage:ia, alive, 2069 days	1841.1
TCGA-2G-AAH4-01A	34 years, male, white, stage:ii, alive, 6210 days	1839.4
TCGA-2G-AAGC-01A	28 years, male, white, stage:is, alive, 2585 days	1830.3
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:iiic, dead, 17 days	1787.6
TCGA-2G-AAGA-01A	38 years, male, white, stage:iia, alive, 2439 days	1757.8
TCGA-XE-AAO6-01A	47 years, male, white, stage:ia, alive, 240 days	1750.3
TCGA-XE-A8H1-01A	24 years, male, white, stage:is, alive, 209 days	1740.6
TCGA-2G-AAEX-01A	38 years, male, white, stage:is, alive, 1259 days	1736.8
TCGA-XE-A9SE-01A	35 years, male, white, stage:ia, alive, 708 days	1729.8
TCGA-W4-A7U3-01A	26 years, male, white, alive, 149 days	1725.1
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:ia, alive, 2938 days	1708.6
TCGA-2G-AAGX-01A	22 years, male, white, stage:ia, alive, 5514 days	1701.0
TCGA-2G-AAKM-01A	14 years, male, white, stage:ii, dead, 6972 days	1694.0
TCGA-2G-AAGE-01A	21 years, male, white, stage:is, alive, 2478 days	1687.2
TCGA-2G-AAFH-01A	38 years, male, white, stage:iib, alive, 1375 days	1680.8
TCGA-2G-AAGI-01A	33 years, male, white, stage:is, alive, 3137 days	1680.1
TCGA-XE-A8H5-01A	29 years, male, stage:is, alive, 1217 days	1670.3
TCGA-2G-AAGY-01A	28 years, male, white, stage:is, alive, 5329 days	1662.0
TCGA-2G-AAFI-01A	41 years, male, white, stage:ib, alive, 675 days	1644.8
TCGA-XE-AAOD-01A	39 years, male, white, stage:ib, alive, 2058 days	1623.3
TCGA-2G-AAFE-01A	37 years, male, white, stage:iia, alive, 4702 days	1621.7
TCGA-2G-AAFZ-01A	32 years, male, white, stage:iii, alive, 1353 days	1618.0
TCGA-2G-AAL5-01A	31 years, male, white, stage:i, alive, 7437 days	1616.2
TCGA-XY-A9T9-01A	37 years, male, white, stage:is, alive, 281 days	1604.8
TCGA-2G-AAGG-01A	20 years, male, white, stage:iiic, alive, 2611 days	1604.5
TCGA-2G-AAH2-01A	20 years, male, white, stage:is, alive, 6060 days	1603.9
TCGA-XE-A8H4-01A	23 years, male, white, stage:ia, alive, 559 days	1602.3
TCGA-XE-AANI-01A	37 years, male, white, stage:is, alive, 1041 days	1595.7
TCGA-VF-A8AA-01A	51 years, male, white, stage:i, alive, 1146 days	1594.7
TCGA-SN-A84X-01A	21 years, male, white, stage:is, alive, 312 days	1578.7
TCGA-YU-A912-01A	34 years, male, black or african american, stage:iiic, alive, 866 days	1563.8
TCGA-YU-A90W-01A	45 years, male, white, stage:ia, alive, 1113 days	1550.8
TCGA-2G-AAG9-01A	25 years, male, white, stage:iiib, alive, 2234 days	1547.5
TCGA-WZ-A7V4-01A	28 years, male, white, stage:i, alive, 894 days	1547.0
TCGA-SB-A6J6-01A	22 years, male, white, stage:ia, alive, 413 days	1542.2
TCGA-4K-AAAL-01A	31 years, male, white, stage:is, alive, 483 days	1540.4
TCGA-2G-AAG5-01A	36 years, male, white, stage:is, alive, 2299 days	1539.6
TCGA-XE-AAO4-01A	40 years, male, white, stage:ia, alive, 367 days	1536.6
TCGA-2G-AAH0-01A	30 years, male, white, stage:is, alive, 5477 days	1527.5
TCGA-XE-AAO3-01A	33 years, male, asian, stage:i, alive, 2857 days	1521.9
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:i, alive, 13 days	1518.0
TCGA-2G-AAF4-01A	30 years, male, white, stage:i, alive, 2315 days	1482.6
TCGA-2G-AAHT-01A	32 years, male, white, stage:is, alive, 542 days	1467.5
TCGA-YU-A94I-01A	66 years, male, stage:ia, alive, 536 days	1466.9
TCGA-XY-A89B-01A	35 years, male, white, stage:ia, alive, 471 days	1431.7
TCGA-SB-A76C-01A	38 years, male, white, alive, 42 days	1424.3
TCGA-2G-AAH8-01A	45 years, male, white, stage:iiic, alive, 2248 days	1415.9
TCGA-2G-AAEW-01A	31 years, male, white, stage:is, dead, 618 days	1396.3
TCGA-SN-A6IS-01A	26 years, male, white, stage:is, alive, 496 days	1393.2
TCGA-XE-AANR-01A	24 years, male, white, stage:i, alive, 14 days	1371.6
TCGA-2G-AAF1-01A	28 years, male, asian, stage:is, alive, 1403 days	1354.9
TCGA-2G-AAHP-01A	31 years, male, white, stage:is, alive, 5667 days	1350.3
TCGA-WZ-A7V3-01A	20 years, male, white, stage:i, alive, 753 days	1349.8
TCGA-2G-AAF6-01A	28 years, male, white, stage:is, alive, 3491 days	1337.8
TCGA-2G-AAGM-01A	51 years, male, white, stage:is, alive, 3891 days	1320.3
TCGA-2G-AAGO-01A	41 years, male, white, stage:is, alive, 4026 days	1312.6
TCGA-XE-AAOC-01A	31 years, male, white, stage:ia, alive, 270 days	1304.5
TCGA-2G-AAG3-01A	53 years, male, white, stage:is, alive, 1593 days	1282.6
TCGA-2G-AAFJ-01A	23 years, male, asian, alive, 792 days	1260.8
TCGA-2X-A9D5-01A	49 years, male, white, stage:i, alive, 435 days	1251.8
TCGA-S6-A8JW-01A	37 years, male, white, stage:is, alive, 698 days	1249.8
TCGA-YU-A94D-01A	28 years, male, stage:iiib, alive, 2167 days	1249.4
TCGA-XE-AANJ-01A	39 years, male, white, stage:is, alive, 2007 days	1238.9
TCGA-XE-AANV-01A	52 years, male, stage:ib, alive, 1701 days	1233.6
TCGA-SN-A84W-01A	30 years, male, white, stage:is, alive, 293 days	1223.7
TCGA-WZ-A7V5-01A	27 years, male, white, stage:i, alive, 1061 days	1217.1
TCGA-W4-A7U2-01A	26 years, male, white, alive, 1263 days	1209.6
TCGA-2X-A9D6-01A	42 years, male, white, stage:i, alive, 607 days	1170.8
TCGA-2G-AAHG-01A	25 years, male, white, stage:i, alive, 1819 days	1158.8
TCGA-4K-AA1G-01A	34 years, male, white, stage:is, alive, 436 days	1121.1
TCGA-S6-A8JY-01A	27 years, male, white, stage:is, alive, 278 days	1105.0
TCGA-ZM-AA06-01A	45 years, male, white, stage:ib, alive, 1498 days	1094.2
TCGA-2G-AAF8-01A	33 years, male, white, stage:ia, alive, 3911 days	1046.1
TCGA-S6-A8JX-01A	27 years, male, white, stage:ib, alive, 552 days	982.1
TCGA-2G-AAH3-01A	20 years, male, white, stage:i, alive, 1822 days	897.1
TCGA-SO-A8JP-01A	29 years, male, white, stage:i, alive, 540 days	747.7
TCGA-YU-A90Q-01A	21 years, male, stage:ib, alive, 1964 days	711.0
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TESTIS CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA041264	Antibody HPA041271	Antibody CAB002621
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details