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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q14.3
Chromosome location (bp)
88717117 - 88904257
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0045893[positive regulation of DNA-templated transcription] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0048513[animal organ development]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors alpha-Helices exposed by beta-structures Disease related genes Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000165[MAPK cascade] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001649[osteoblast differentiation] GO:0001764[neuron migration] GO:0001782[B cell homeostasis] GO:0001947[heart looping] GO:0001958[endochondral ossification] GO:0001974[blood vessel remodeling] GO:0002062[chondrocyte differentiation] GO:0002467[germinal center formation] GO:0002634[regulation of germinal center formation] GO:0002931[response to ischemia] GO:0003138[primary heart field specification] GO:0003139[secondary heart field specification] GO:0003151[outflow tract morphogenesis] GO:0003185[sinoatrial valve morphogenesis] GO:0003211[cardiac ventricle formation] GO:0003677[DNA binding] GO:0003680[minor groove of adenine-thymine-rich DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006959[humoral immune response] GO:0007399[nervous system development] GO:0007507[heart development] GO:0007517[muscle organ development] GO:0007519[skeletal muscle tissue development] GO:0007521[muscle cell fate determination] GO:0007611[learning or memory] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010694[positive regulation of alkaline phosphatase activity] GO:0014033[neural crest cell differentiation] GO:0014902[myotube differentiation] GO:0016528[sarcoplasm] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0030220[platelet formation] GO:0030279[negative regulation of ossification] GO:0030318[melanocyte differentiation] GO:0030501[positive regulation of bone mineralization] GO:0030890[positive regulation of B cell proliferation] GO:0032991[protein-containing complex] GO:0035984[cellular response to trichostatin A] GO:0042100[B cell proliferation] GO:0042826[histone deacetylase binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043406[positive regulation of MAP kinase activity] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045652[regulation of megakaryocyte differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046928[regulation of neurotransmitter secretion] GO:0046982[protein heterodimerization activity] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048513[animal organ development] GO:0048643[positive regulation of skeletal muscle tissue development] GO:0048666[neuron development] GO:0048667[cell morphogenesis involved in neuron differentiation] GO:0050853[B cell receptor signaling pathway] GO:0051145[smooth muscle cell differentiation] GO:0051963[regulation of synapse assembly] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060025[regulation of synaptic activity] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060079[excitatory postsynaptic potential] GO:0060998[regulation of dendritic spine development] GO:0061333[renal tubule morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071277[cellular response to calcium ion] GO:0071374[cellular response to parathyroid hormone stimulus] GO:0071466[cellular response to xenobiotic stimulus] GO:0071498[cellular response to fluid shear stress] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072102[glomerulus morphogenesis] GO:0072160[nephron tubule epithelial cell differentiation] GO:0098794[postsynapse] GO:0140297[DNA-binding transcription factor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000111[positive regulation of macrophage apoptotic process] GO:2000310[regulation of NMDA receptor activity] GO:2000311[regulation of AMPA receptor activity] GO:2000727[positive regulation of cardiac muscle cell differentiation] GO:2000987[positive regulation of behavioral fear response] GO:2001013[epithelial cell proliferation involved in renal tubule morphogenesis] GO:2001016[positive regulation of skeletal muscle cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Other congenital disorders Chromosomal abnormalities Other diseases Mental and behavioural disorders