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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q32.3
Chromosome location (bp)
211326615 - 211374946
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0009898[cytoplasmic side of plasma membrane] GO:0023019[signal transduction involved in regulation of gene expression] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035631[CD40 receptor complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046330[positive regulation of JNK cascade] GO:0046872[metal ion binding] GO:0048255[mRNA stabilization] GO:0048584[positive regulation of response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070534[protein K63-linked ubiquitination] GO:0097400[interleukin-17-mediated signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035631[CD40 receptor complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046330[positive regulation of JNK cascade] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070534[protein K63-linked ubiquitination]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035631[CD40 receptor complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046330[positive regulation of JNK cascade] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070534[protein K63-linked ubiquitination]
The Human Protein Atlas project is funded
