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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Metabolic proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p23.3
Chromosome location (bp)
24491254 - 24770702
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Acyltransferase, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000435[positive regulation of transcription from RNA polymerase II promoter by galactose] GO:0000785[chromatin] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:1900076[regulation of cellular response to insulin stimulus] GO:1904179[positive regulation of adipose tissue development]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000435[positive regulation of transcription from RNA polymerase II promoter by galactose] GO:0000785[chromatin] GO:0002155[regulation of thyroid hormone mediated signaling pathway] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043065[positive regulation of apoptotic process] GO:0045666[positive regulation of neuron differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0060713[labyrinthine layer morphogenesis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:1900076[regulation of cellular response to insulin stimulus] GO:1904017[cellular response to Thyroglobulin triiodothyronine] GO:1904179[positive regulation of adipose tissue development]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000435[positive regulation of transcription from RNA polymerase II promoter by galactose] GO:0000785[chromatin] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:1900076[regulation of cellular response to insulin stimulus] GO:1904179[positive regulation of adipose tissue development]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435[positive regulation of transcription from RNA polymerase II promoter by galactose] GO:0000785[chromatin] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:1900076[regulation of cellular response to insulin stimulus] GO:1904179[positive regulation of adipose tissue development]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000435[positive regulation of transcription from RNA polymerase II promoter by galactose] GO:0000785[chromatin] GO:0003713[transcription coactivator activity] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0030331[nuclear estrogen receptor binding] GO:0030374[nuclear receptor coactivator activity] GO:0032870[cellular response to hormone stimulus] GO:0032991[protein-containing complex] GO:0035357[peroxisome proliferator activated receptor signaling pathway] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046983[protein dimerization activity] GO:0047485[protein N-terminus binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0090575[RNA polymerase II transcription regulator complex] GO:1900076[regulation of cellular response to insulin stimulus] GO:1904179[positive regulation of adipose tissue development]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
