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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Microtubule associated protein RP/EB family member 3
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p23.3
Chromosome location (bp)
26970637 - 27027219
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton 1,2. Promotes microtubule growth 3,4. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes 5,6. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement 7. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules 8....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, Mitosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9UPY8 [Direct mapping] Microtubule-associated protein RP/EB family member 3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005881[cytoplasmic microtubule] GO:0007049[cell cycle] GO:0008017[microtubule binding] GO:0008022[protein C-terminus binding] GO:0008104[protein localization] GO:0015630[microtubule cytoskeleton] GO:0019901[protein kinase binding] GO:0030496[midbody] GO:0031110[regulation of microtubule polymerization or depolymerization] GO:0031113[regulation of microtubule polymerization] GO:0035371[microtubule plus-end] GO:0035372[protein localization to microtubule] GO:0042802[identical protein binding] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045860[positive regulation of protein kinase activity] GO:0045893[positive regulation of DNA-templated transcription] GO:0048471[perinuclear region of cytoplasm] GO:0051010[microtubule plus-end binding] GO:0051225[spindle assembly] GO:0051233[spindle midzone] GO:0051301[cell division] GO:1903033[positive regulation of microtubule plus-end binding] GO:1905721[mitotic spindle astral microtubule end]
Q9UPY8 [Direct mapping] Microtubule-associated protein RP/EB family member 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q9UPY8 [Direct mapping] Microtubule-associated protein RP/EB family member 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Q9UPY8 [Direct mapping] Microtubule-associated protein RP/EB family member 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
