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                                  PATHOLOGY GLIOMA Show tissue menu
                                  BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA
                                  MELANOMA OVARIAN CANCER PANCREATIC CANCER PROSTATE CANCER RENAL CANCER SKIN CANCER STOMACH CANCER TESTIS CANCER THYROID CANCER UROTHELIAL CANCER
                                  ANTIBODIES
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                                  Glioma
                                  Human pathology
                                  Glioma
                                  GLIOMA - Interactive survival scatter ploti

                                  The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

                                  The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

                                  Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

                                  Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

                                  & Survival analysisi

                                  Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.

                                  FTL is not prognostic in glioma


                                  Stage:
                                  0 1 2 3 4 5 6 7Time after diagnosis (years)0.02.0k4.0k6.0k8.0k10k12k14k16k18k20kExpression level (FPKM)Dead (n=123)Alive (n=30)3.4e+3Density dead2.6e+3Density alive1.2Density dead under cut off0.89Density dead over cut off0.00.20.40.60.81.0P score0.00.40.30.20.60.81.0Medain separation0.1P scoreDead median separationCut off
                                  0.00.10.20.30.40.50.60.70.80.91.0Survival probability 0 1 2 3 4 5 6 7Time (years)Low expression (n=42)High expression (n=111)
                                  Survival analysis
                                  Current cut offi

                                  Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.

                                  :
                                  Best expression cut offi

                                  Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .

                                  When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.

                                  : 2342.66
                                  Median expressioni

                                  Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.

                                  : 3404.26
                                  Median follow up timei

                                  Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.

                                  : 0.94
                                  P scorei

                                  Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.

                                  0.067
                                  3-year survival highi

                                  5-year survival for patients with higher expression than the expression cutoff.

                                  For melanoma and glioma, 3-year survival is shown.

                                  6%
                                  3-year survival lowi

                                  5-year survival for patients with lower expression than the expression cutoff.

                                  For melanoma and glioma, 3-year survival is shown.

                                  17%
                                  TCGA RNA samplesi

                                  RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .

                                  Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.

                                  Average FPKM 4015.5
                                  Number of samples 153
                                  Samples
                                  Sample Description FPKM
                                  TCGA-06-0139-01A 40 years, male, white, dead, 362 days 21576.3
                                  TCGA-06-5410-01A 72 years, female, white, dead, 108 days 13780.4
                                  TCGA-02-2486-01A 64 years, male, white, dead, 618 days 11520.5
                                  TCGA-28-1753-01A 53 years, male, white, alive, 37 days 11381.6
                                  TCGA-06-0141-01A 62 years, male, white, dead, 313 days 11106.8
                                  TCGA-06-0178-01A 39 years, male, white, dead, 2681 days 9340.7
                                  TCGA-06-0132-01A 49 years, male, white, dead, 771 days 8910.3
                                  TCGA-06-0219-01A 67 years, male, white, dead, 22 days 8799.7
                                  TCGA-14-0817-01A 69 years, female, white, dead, 164 days 8746.8
                                  TCGA-28-5213-01A 72 years, male, white, alive, 951 days 8256.9
                                  TCGA-06-0645-01A 56 years, female, white, dead, 175 days 8138.9
                                  TCGA-06-0749-01A 50 years, male, black or african american, dead, 82 days 8008.0
                                  TCGA-27-2524-01A 56 years, male, white, dead, 231 days 7950.6
                                  TCGA-14-1829-01A 57 years, male, black or african american, alive, 218 days 7688.0
                                  TCGA-06-0130-01A 54 years, male, white, dead, 394 days 7231.1
                                  TCGA-06-0184-01A 63 years, male, white, dead, 2126 days 6810.0
                                  TCGA-14-1823-01A 58 years, female, white, dead, 543 days 6704.2
                                  TCGA-32-1980-01A 72 years, male, white, dead, 36 days 6660.9
                                  TCGA-06-5412-01A 78 years, female, white, dead, 138 days 6440.8
                                  TCGA-06-0750-01A 43 years, male, white, dead, 28 days 6285.9
                                  TCGA-16-1045-01B 49 years, female, white, dead, 883 days 6167.8
                                  TCGA-14-0789-01A 54 years, male, white, dead, 342 days 6138.8
                                  TCGA-06-0238-01A 46 years, male, white, dead, 405 days 6066.2
                                  TCGA-27-1831-01A 66 years, male, white, dead, 505 days 6048.6
                                  TCGA-32-5222-01A 66 years, male, white, dead, 585 days 5998.5
                                  TCGA-02-0055-01A 62 years, female, white, dead, 76 days 5993.6
                                  TCGA-12-1597-01B 62 years, female, white, dead, 675 days 5989.4
                                  TCGA-28-5208-01A 52 years, male, white, dead, 544 days 5596.1
                                  TCGA-19-4065-01A 36 years, male, white, alive, 214 days 5517.5
                                  TCGA-02-2483-01A 43 years, male, asian, alive, 466 days 5477.1
                                  TCGA-06-0210-01A 72 years, female, white, dead, 225 days 5461.9
                                  TCGA-06-0138-01A 43 years, male, white, dead, 737 days 5395.4
                                  TCGA-14-0787-01A 69 years, male, asian, dead, 68 days 5340.4
                                  TCGA-32-4213-01A 47 years, female, white, alive, 604 days 5184.3
                                  TCGA-12-5299-01A 56 years, female, white, dead, 98 days 5099.2
                                  TCGA-27-2526-01A 79 years, female, white, dead, 87 days 5098.6
                                  TCGA-12-3650-01A 46 years, male, white, dead, 333 days 5082.1
                                  TCGA-12-0619-01A 60 years, male, white, dead, 1062 days 5019.2
                                  TCGA-41-3915-01A 48 years, male, white, dead, 360 days 4950.5
                                  TCGA-41-2571-01A 89 years, male, white, dead, 26 days 4884.0
                                  TCGA-76-4927-01A 58 years, male, white, dead, 535 days 4840.0
                                  TCGA-06-5411-01A 51 years, male, white, dead, 254 days 4829.2
                                  TCGA-06-0649-01B 73 years, female, black or african american, dead, 64 days 4758.5
                                  TCGA-06-2557-01A 76 years, male, black or african american, dead, 33 days 4731.1
                                  TCGA-06-0156-01A 57 years, male, white, dead, 178 days 4573.5
                                  TCGA-26-5135-01A 72 years, female, white, dead, 270 days 4541.3
                                  TCGA-06-0744-01A 67 years, male, white, dead, 1426 days 4456.1
                                  TCGA-28-2513-01A 69 years, female, white, alive, 222 days 4434.0
                                  TCGA-14-2554-01A 52 years, female, white, dead, 532 days 4433.9
                                  TCGA-06-5413-01A 67 years, male, white, alive, 268 days 4433.7
                                  TCGA-06-5418-01A 75 years, female, white, dead, 83 days 4423.8
                                  TCGA-16-0846-01A 85 years, male, white, dead, 119 days 4356.0
                                  TCGA-26-5132-01A 74 years, male, white, alive, 286 days 4334.4
                                  TCGA-32-2616-01A 48 years, female, white, dead, 224 days 4288.0
                                  TCGA-06-0190-01A 62 years, male, white, dead, 317 days 4222.9
                                  TCGA-12-5295-01A 60 years, female, white, dead, 454 days 4111.2
                                  TCGA-06-0644-01A 71 years, male, black or african american, dead, 384 days 4094.5
                                  TCGA-06-2564-01A 50 years, male, white, alive, 181 days 4065.4
                                  TCGA-06-0745-01A 59 years, male, white, dead, 239 days 4014.5
                                  TCGA-76-4929-01A 76 years, female, white, dead, 111 days 4000.6
                                  TCGA-12-3652-01A 60 years, male, white, dead, 1062 days 3995.4
                                  TCGA-28-1747-01C 44 years, male, white, dead, 77 days 3936.7
                                  TCGA-19-2625-01A 76 years, female, white, dead, 124 days 3857.1
                                  TCGA-28-5218-01A 63 years, male, white, dead, 157 days 3778.0
                                  TCGA-06-2570-01A 21 years, female, white, alive, 958 days 3698.8
                                  TCGA-27-1834-01A 56 years, male, white, dead, 1233 days 3662.8
                                  TCGA-28-5220-01A 67 years, male, white, dead, 388 days 3641.1
                                  TCGA-06-0168-01A 59 years, female, white, dead, 598 days 3568.5
                                  TCGA-32-2615-01A 62 years, male, white, dead, 485 days 3564.7
                                  TCGA-06-0882-01A 30 years, male, white, dead, 632 days 3511.7
                                  TCGA-32-2638-01A 67 years, male, white, dead, 766 days 3486.5
                                  TCGA-14-0781-01B 49 years, male, black or african american, dead, 29 days 3481.8
                                  TCGA-06-5856-01A 58 years, male, white, dead, 114 days 3435.2
                                  TCGA-06-2558-01A 75 years, female, white, dead, 380 days 3429.1
                                  TCGA-27-1830-01A 57 years, male, white, dead, 154 days 3426.8
                                  TCGA-19-1787-01B 49 years, male, white, dead, 385 days 3422.4
                                  TCGA-28-5216-01A 52 years, male, white, alive, 415 days 3404.3
                                  TCGA-32-1982-01A 76 years, female, white, dead, 142 days 3381.7
                                  TCGA-32-2632-01A 80 years, male, white, dead, 269 days 3367.0
                                  TCGA-26-5136-01B 78 years, female, white, dead, 577 days 3332.8
                                  TCGA-06-0129-01A 30 years, male, asian, dead, 1024 days 3314.3
                                  TCGA-41-2572-01A 67 years, male, white, dead, 406 days 3306.7
                                  TCGA-06-0646-01A 61 years, male, white, dead, 175 days 3247.2
                                  TCGA-27-1832-01A 59 years, female, white, dead, 300 days 3211.5
                                  TCGA-06-0743-01A 69 years, male, white, dead, 803 days 3207.8
                                  TCGA-06-0878-01A 74 years, male, white, alive, 218 days 3192.4
                                  TCGA-06-2567-01A 65 years, male, white, dead, 133 days 3160.3
                                  TCGA-12-0821-01A 62 years, male, white, dead, 323 days 3128.2
                                  TCGA-76-4928-01B 85 years, female, white, dead, 94 days 3085.3
                                  TCGA-06-5414-01A 61 years, male, white, alive, 273 days 2996.4
                                  TCGA-12-0616-01A 36 years, female, white, dead, 448 days 2971.1
                                  TCGA-06-0174-01A 54 years, male, white, dead, 98 days 2968.8
                                  TCGA-06-2562-01A 81 years, male, white, dead, 382 days 2954.8
                                  TCGA-28-2499-01A 59 years, male, white, dead, 95 days 2898.2
                                  TCGA-28-5215-01A 62 years, female, white, dead, 335 days 2793.7
                                  TCGA-19-2620-01A 70 years, male, white, dead, 148 days 2792.9
                                  TCGA-14-1034-01A 60 years, female, dead, 485 days 2754.0
                                  TCGA-06-0187-01A 69 years, male, white, dead, 828 days 2749.7
                                  TCGA-76-4926-01B 68 years, male, white, dead, 138 days 2705.5
                                  TCGA-06-0686-01A 53 years, male, white, dead, 432 days 2697.5
                                  TCGA-28-2509-01A 77 years, female, white, alive, 145 days 2682.3
                                  TCGA-27-2519-01A 48 years, male, white, dead, 550 days 2680.1
                                  TCGA-06-0157-01A 63 years, female, white, dead, 97 days 2606.4
                                  TCGA-19-2629-01A 60 years, male, white, dead, 737 days 2562.5
                                  TCGA-26-5133-01A 59 years, male, white, alive, 452 days 2525.4
                                  TCGA-32-2634-01A 82 years, male, white, alive, 693 days 2498.4
                                  TCGA-27-2523-01A 63 years, male, white, dead, 489 days 2474.0
                                  TCGA-06-5408-01A 54 years, female, white, dead, 357 days 2453.7
                                  TCGA-06-2559-01A 83 years, male, white, dead, 150 days 2428.1
                                  TCGA-41-4097-01A 63 years, female, white, dead, 6 days 2413.5
                                  TCGA-06-0158-01A 73 years, male, white, dead, 329 days 2376.7
                                  TCGA-76-4932-01A 50 years, female, white, dead, 1458 days 2308.6
                                  TCGA-06-5858-01A 45 years, female, white, alive, 187 days 2285.8
                                  TCGA-14-0871-01A 75 years, female, white, dead, 880 days 2283.5
                                  TCGA-15-1444-01A 21 years, male, white, dead, 1537 days 2279.0
                                  TCGA-76-4925-01A 76 years, male, white, dead, 146 days 2265.4
                                  TCGA-14-1825-01A 70 years, male, white, dead, 232 days 2229.7
                                  TCGA-26-5134-01A 74 years, male, white, alive, 167 days 2192.3
                                  TCGA-27-1837-01A 36 years, male, white, dead, 427 days 2143.9
                                  TCGA-15-0742-01A 65 years, male, white, dead, 419 days 2116.9
                                  TCGA-06-2569-01A 24 years, female, black or african american, alive, 13 days 2116.1
                                  TCGA-27-2521-01A 34 years, male, white, dead, 510 days 2098.1
                                  TCGA-02-0047-01A 78 years, male, white, dead, 448 days 2038.4
                                  TCGA-06-2565-01A 59 years, male, asian, dead, 506 days 2037.5
                                  TCGA-12-0618-01A 49 years, male, white, dead, 395 days 2002.9
                                  TCGA-26-1442-01A 43 years, male, white, alive, 953 days 1998.4
                                  TCGA-06-2563-01A 72 years, female, white, alive, 932 days 1973.5
                                  TCGA-19-1390-01A 63 years, female, white, dead, 772 days 1912.3
                                  TCGA-76-4931-01A 70 years, female, white, dead, 279 days 1844.4
                                  TCGA-26-5139-01A 65 years, female, white, alive, 48 days 1839.0
                                  TCGA-08-0386-01A 74 years, male, white, dead, 548 days 1746.4
                                  TCGA-19-2624-01A 51 years, male, white, dead, 5 days 1663.6
                                  TCGA-06-0211-01B 47 years, male, white, dead, 360 days 1652.9
                                  TCGA-02-2485-01A 53 years, male, black or african american, alive, 470 days 1575.8
                                  TCGA-06-2561-01A 53 years, female, white, dead, 537 days 1563.9
                                  TCGA-28-5207-01A 71 years, male, white, dead, 343 days 1563.7
                                  TCGA-27-2528-01A 62 years, male, white, dead, 480 days 1530.1
                                  TCGA-06-5859-01A 63 years, male, white, alive, 139 days 1526.1
                                  TCGA-28-5204-01A 72 years, male, white, dead, 454 days 1479.5
                                  TCGA-28-5209-01A 66 years, female, white, alive, 77 days 1461.7
                                  TCGA-06-0747-01A 53 years, male, white, dead, 82 days 1448.4
                                  TCGA-14-0790-01B 64 years, female, white, dead, 419 days 1412.2
                                  TCGA-27-1835-01A 53 years, female, white, dead, 648 days 1393.3
                                  TCGA-19-5960-01A 56 years, male, white, dead, 455 days 1364.4
                                  TCGA-12-3653-01A 34 years, female, white, dead, 442 days 1332.6
                                  TCGA-41-5651-01A 59 years, female, black or african american, dead, 460 days 1217.8
                                  TCGA-06-5416-01A 23 years, female, white, alive, 204 days 1203.6
                                  TCGA-06-0125-01A 63 years, female, white, dead, 1448 days 1195.1
                                  TCGA-06-5417-01A 45 years, female, white, alive, 155 days 1169.9
                                  TCGA-28-2514-01A 45 years, male, asian, alive, 160 days 1105.5
                                  TCGA-06-1804-01A 81 years, female, white, dead, 414 days 1006.5
                                  TCGA-19-2619-01A 55 years, female, black or african american, alive, 294 days 912.6
                                  TCGA-32-1970-01A 59 years, male, white, dead, 468 days 883.9
                                  Show allShow less
                                  2279.03404.34950.5883.98910.302,0004,0006,0008,00010,00012,00014,00016,00018,00020,000
                                  2279.03404.34950.5883.98910.302,0004,0006,0008,00010,00012,00014,00016,00018,00020,000
                                  GLIOMA - Protein expressioni

                                  A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.

                                  Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

                                   

                                  Antibody stainingi

                                  Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.

                                  Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.


                                  Antibody HPA041602

                                  Antibody CAB020769
                                   Staining
                                    High
                                    Medium
                                    Low
                                    Not detected
                                   Intensity
                                    Strong
                                    Moderate
                                    Weak
                                    Negative
                                   Quantity
                                    >75%
                                    75%-25%
                                    <25%
                                    None
                                   Location
                                    Nuclear
                                    Cytoplasmic/membranous
                                    Cytoplasmic/membranous,nuclear
                                    None
                                  Click images for details

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