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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q24.22
Chromosome location (bp)
117208142 - 117452170
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding, Oxidoreductase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Transporters Accessory Factors Involved in Transport SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666[response to hypoxia] GO:0001917[photoreceptor inner segment] GO:0002028[regulation of sodium ion transport] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006527[arginine catabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0006936[muscle contraction] GO:0006941[striated muscle contraction] GO:0007263[nitric oxide mediated signal transduction] GO:0007520[myoblast fusion] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010523[negative regulation of calcium ion transport into cytosol] GO:0012506[vesicle membrane] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016529[sarcoplasmic reticulum] GO:0017080[sodium channel regulator activity] GO:0018119[peptidyl-cysteine S-nitrosylation] GO:0020037[heme binding] GO:0031284[positive regulation of guanylate cyclase activity] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033555[multicellular organismal response to stress] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0035066[positive regulation of histone acetylation] GO:0042136[neurotransmitter biosynthetic process] GO:0042178[xenobiotic catabolic process] GO:0042311[vasodilation] GO:0042383[sarcolemma] GO:0042995[cell projection] GO:0043197[dendritic spine] GO:0043267[negative regulation of potassium ion transport] GO:0044249[cellular biosynthetic process] GO:0044325[transmembrane transporter binding] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045454[cell redox homeostasis] GO:0045776[negative regulation of blood pressure] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046870[cadmium ion binding] GO:0046872[metal ion binding] GO:0048306[calcium-dependent protein binding] GO:0048471[perinuclear region of cytoplasm] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0051346[negative regulation of hydrolase activity] GO:0051612[negative regulation of serotonin uptake] GO:0051926[negative regulation of calcium ion transport] GO:0055117[regulation of cardiac muscle contraction] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0071363[cellular response to growth factor stimulus] GO:0071944[cell periphery] GO:0097110[scaffold protein binding] GO:0098735[positive regulation of the force of heart contraction] GO:0098924[retrograde trans-synaptic signaling by nitric oxide] GO:1902307[positive regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Transporters Accessory Factors Involved in Transport SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666[response to hypoxia] GO:0001917[photoreceptor inner segment] GO:0002028[regulation of sodium ion transport] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006527[arginine catabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0006936[muscle contraction] GO:0006941[striated muscle contraction] GO:0007263[nitric oxide mediated signal transduction] GO:0007520[myoblast fusion] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010523[negative regulation of calcium ion transport into cytosol] GO:0012506[vesicle membrane] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016529[sarcoplasmic reticulum] GO:0017080[sodium channel regulator activity] GO:0018119[peptidyl-cysteine S-nitrosylation] GO:0020037[heme binding] GO:0031284[positive regulation of guanylate cyclase activity] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033555[multicellular organismal response to stress] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0035066[positive regulation of histone acetylation] GO:0042136[neurotransmitter biosynthetic process] GO:0042178[xenobiotic catabolic process] GO:0042311[vasodilation] GO:0042383[sarcolemma] GO:0042995[cell projection] GO:0043197[dendritic spine] GO:0043267[negative regulation of potassium ion transport] GO:0044249[cellular biosynthetic process] GO:0044325[transmembrane transporter binding] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045454[cell redox homeostasis] GO:0045776[negative regulation of blood pressure] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046870[cadmium ion binding] GO:0046872[metal ion binding] GO:0048306[calcium-dependent protein binding] GO:0048471[perinuclear region of cytoplasm] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0051346[negative regulation of hydrolase activity] GO:0051612[negative regulation of serotonin uptake] GO:0051926[negative regulation of calcium ion transport] GO:0055117[regulation of cardiac muscle contraction] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0071363[cellular response to growth factor stimulus] GO:0071944[cell periphery] GO:0097110[scaffold protein binding] GO:0098735[positive regulation of the force of heart contraction] GO:0098924[retrograde trans-synaptic signaling by nitric oxide] GO:1902307[positive regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666[response to hypoxia] GO:0001917[photoreceptor inner segment] GO:0002028[regulation of sodium ion transport] GO:0004517[nitric-oxide synthase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006527[arginine catabolic process] GO:0006809[nitric oxide biosynthetic process] GO:0006936[muscle contraction] GO:0006941[striated muscle contraction] GO:0007263[nitric oxide mediated signal transduction] GO:0007520[myoblast fusion] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010181[FMN binding] GO:0010523[negative regulation of calcium ion transport into cytosol] GO:0012506[vesicle membrane] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016529[sarcoplasmic reticulum] GO:0017080[sodium channel regulator activity] GO:0018119[peptidyl-cysteine S-nitrosylation] GO:0020037[heme binding] GO:0031284[positive regulation of guanylate cyclase activity] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033555[multicellular organismal response to stress] GO:0034617[tetrahydrobiopterin binding] GO:0034618[arginine binding] GO:0035066[positive regulation of histone acetylation] GO:0042136[neurotransmitter biosynthetic process] GO:0042178[xenobiotic catabolic process] GO:0042311[vasodilation] GO:0042383[sarcolemma] GO:0042995[cell projection] GO:0043197[dendritic spine] GO:0043267[negative regulation of potassium ion transport] GO:0044249[cellular biosynthetic process] GO:0044325[transmembrane transporter binding] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045454[cell redox homeostasis] GO:0045776[negative regulation of blood pressure] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046870[cadmium ion binding] GO:0046872[metal ion binding] GO:0048306[calcium-dependent protein binding] GO:0048471[perinuclear region of cytoplasm] GO:0050660[flavin adenine dinucleotide binding] GO:0050661[NADP binding] GO:0051346[negative regulation of hydrolase activity] GO:0051612[negative regulation of serotonin uptake] GO:0051926[negative regulation of calcium ion transport] GO:0055117[regulation of cardiac muscle contraction] GO:0060314[regulation of ryanodine-sensitive calcium-release channel activity] GO:0071363[cellular response to growth factor stimulus] GO:0071944[cell periphery] GO:0097110[scaffold protein binding] GO:0098735[positive regulation of the force of heart contraction] GO:0098924[retrograde trans-synaptic signaling by nitric oxide] GO:1902307[positive regulation of sodium ion transmembrane transport] GO:1902514[regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]