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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes CD markers FDA approved drug targets Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.2
Chromosome location (bp)
10271093 - 10286615
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Host cell receptor for virus entry, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell adhesion, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A0A384MEK5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein
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CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001618[virus receptor activity] GO:0001910[regulation of leukocyte mediated cytotoxicity] GO:0002291[T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell] GO:0002693[positive regulation of cellular extravasation] GO:0004888[transmembrane signaling receptor activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007155[cell adhesion] GO:0007157[heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159[leukocyte cell-cell adhesion] GO:0009986[cell surface] GO:0016020[membrane] GO:0022614[membrane to membrane docking] GO:0038023[signaling receptor activity] GO:0044406[adhesion of symbiont to host] GO:0046718[viral entry into host cell] GO:0046813[receptor-mediated virion attachment to host cell] GO:0050900[leukocyte migration] GO:0061028[establishment of endothelial barrier] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0098609[cell-cell adhesion] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1904646[cellular response to amyloid-beta] GO:2000352[negative regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
