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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q12
Chromosome location (bp)
35005990 - 35089319
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0010008[endosome membrane] GO:0010762[regulation of fibroblast migration] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0032006[regulation of TOR signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872[metal ion binding] GO:0055038[recycling endosome membrane] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001271[negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002020[protease binding] GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0010008[endosome membrane] GO:0010762[regulation of fibroblast migration] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0032006[regulation of TOR signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872[metal ion binding] GO:0055038[recycling endosome membrane] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001271[negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0010008[endosome membrane] GO:0010762[regulation of fibroblast migration] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0032006[regulation of TOR signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872[metal ion binding] GO:0055038[recycling endosome membrane] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001271[negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0010008[endosome membrane] GO:0010762[regulation of fibroblast migration] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0032006[regulation of TOR signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872[metal ion binding] GO:0055038[recycling endosome membrane] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001271[negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0010008[endosome membrane] GO:0010762[regulation of fibroblast migration] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0032006[regulation of TOR signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872[metal ion binding] GO:0055038[recycling endosome membrane] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001271[negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020[protease binding] GO:0002039[p53 binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006915[apoptotic process] GO:0010008[endosome membrane] GO:0010762[regulation of fibroblast migration] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0032006[regulation of TOR signaling] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872[metal ion binding] GO:0055038[recycling endosome membrane] GO:0061630[ubiquitin protein ligase activity] GO:0070936[protein K48-linked ubiquitination] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2001271[negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
The Human Protein Atlas project is funded
