GENERAL INFORMATIONi
Gene namei TREM2
Synonyms TREM-2, Trem2a, Trem2b, Trem2c
Gene descriptioni Triggering receptor expressed on myeloid cells 2
Protein classi Disease related genes
Human disease related genes
Potential drug targets
Transporters
Predicted locationi Secreted, Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 6
Cytoband p21.1
Chromosome location (bp) 41158506 - 41163186
Number of transcriptsi 3
Ensembl ENSG00000095970 (version 109)
Entrez gene 54209
HGNC HGNC:17761
UniProt Q9NZC2 (UniProt - Evidence at protein level)
neXtProt NX_Q9NZC2
GeneCards TREM2
Antibodypedia TREM2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding 1. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia 2, 3. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia 4. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin 5. Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity). Required for microglial phagocytosis of apoptotic neurons 6. Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity). Plays a role in microglial MTOR activation and metabolism (By similarity). Regulates age-related changes in microglial numbers 7. Triggers activation of the immune responses in macrophages and dendritic cells 8. Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival 9. Involved in the positive regulation of osteoclast differentiation 10. show less
Molecular function (UniProt)i Receptor
Ligand (UniProt)i Lipid-binding
Gene summary (Entrez)i This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
TREM2-201
ENSP00000342651
ENST00000338469
Q9NZC2
[Direct mapping] Triggering receptor expressed on myeloid cells 2
Show all
Transporters
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0001540 [amyloid-beta binding]
GO:0001774 [microglial cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002282 [microglial cell activation involved in immune response]
GO:0002588 [positive regulation of antigen processing and presentation of peptide antigen via MHC class II]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006959 [humoral immune response]
GO:0007613 [memory]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008289 [lipid binding]
GO:0008429 [phosphatidylethanolamine binding]
GO:0010468 [regulation of gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010822 [positive regulation of mitochondrion organization]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0010983 [positive regulation of high-density lipoprotein particle clearance]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0019209 [kinase activator activity]
GO:0019216 [regulation of lipid metabolic process]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030316 [osteoclast differentiation]
GO:0032006 [regulation of TOR signaling]
GO:0032008 [positive regulation of TOR signaling]
GO:0032675 [regulation of interleukin-6 production]
GO:0033674 [positive regulation of kinase activity]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034151 [regulation of toll-like receptor 6 signaling pathway]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034189 [very-low-density lipoprotein particle binding]
GO:0034241 [positive regulation of macrophage fusion]
GO:0034351 [negative regulation of glial cell apoptotic process]
GO:0035176 [social behavior]
GO:0038023 [signaling receptor activity]
GO:0038160 [CXCL12-activated CXCR4 signaling pathway]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043277 [apoptotic cell clearance]
GO:0044853 [plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045088 [regulation of innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0045960 [positive regulation of complement activation, classical pathway]
GO:0048143 [astrocyte activation]
GO:0048678 [response to axon injury]
GO:0050714 [positive regulation of protein secretion]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050866 [negative regulation of cell activation]
GO:0050921 [positive regulation of chemotaxis]
GO:0055088 [lipid homeostasis]
GO:0060075 [regulation of resting membrane potential]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0061518 [microglial cell proliferation]
GO:0061889 [negative regulation of astrocyte activation]
GO:0070269 [pyroptosis]
GO:0070345 [negative regulation of fat cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071396 [cellular response to lipid]
GO:0071640 [regulation of macrophage inflammatory protein 1 alpha production]
GO:0071813 [lipoprotein particle binding]
GO:0097028 [dendritic cell differentiation]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0098657 [import into cell]
GO:0110089 [regulation of hippocampal neuron apoptotic process]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0120146 [sulfatide binding]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:0150062 [complement-mediated synapse pruning]
GO:0150079 [negative regulation of neuroinflammatory response]
GO:0150094 [amyloid-beta clearance by cellular catabolic process]
GO:1900015 [regulation of cytokine production involved in inflammatory response]
GO:1900016 [negative regulation of cytokine production involved in inflammatory response]
GO:1900223 [positive regulation of amyloid-beta clearance]
GO:1900226 [negative regulation of NLRP3 inflammasome complex assembly]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1901980 [positive regulation of inward rectifier potassium channel activity]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902531 [regulation of intracellular signal transduction]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903082 [positive regulation of C-C chemokine receptor CCR7 signaling pathway]
GO:1903376 [regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:1903980 [positive regulation of microglial cell activation]
GO:1904093 [negative regulation of autophagic cell death]
GO:1904141 [positive regulation of microglial cell migration]
GO:1904646 [cellular response to amyloid-beta]
GO:1904951 [positive regulation of establishment of protein localization]
GO:1905291 [positive regulation of CAMKK-AMPK signaling cascade]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905805 [excitatory synapse pruning]
GO:1905808 [positive regulation of synapse pruning]
GO:1905907 [negative regulation of amyloid fibril formation]
GO:1990782 [protein tyrosine kinase binding]
GO:2000350 [positive regulation of CD40 signaling pathway]
GO:2001171 [positive regulation of ATP biosynthetic process]
Show all
 219 aa
24.3 kDa 		Yes 0
TREM2-202
ENSP00000362205
ENST00000373113
Q9NZC2
[Direct mapping] Triggering receptor expressed on myeloid cells 2
Show all
Q5TCX1
[Target identity:100%; Query identity:100%] Triggering receptor expressed on myeloid cells 2; cDNA, FLJ92504, Homo sapiens triggering receptor expressed on myeloid cells 2(TREM2), mRNA
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001540 [amyloid-beta binding]
GO:0001774 [microglial cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002282 [microglial cell activation involved in immune response]
GO:0002588 [positive regulation of antigen processing and presentation of peptide antigen via MHC class II]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0002931 [response to ischemia]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006911 [phagocytosis, engulfment]
GO:0006959 [humoral immune response]
GO:0007613 [memory]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008289 [lipid binding]
GO:0008429 [phosphatidylethanolamine binding]
GO:0010468 [regulation of gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010822 [positive regulation of mitochondrion organization]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0010983 [positive regulation of high-density lipoprotein particle clearance]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0019209 [kinase activator activity]
GO:0019216 [regulation of lipid metabolic process]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030316 [osteoclast differentiation]
GO:0032006 [regulation of TOR signaling]
GO:0032008 [positive regulation of TOR signaling]
GO:0032497 [detection of lipopolysaccharide]
GO:0032499 [detection of peptidoglycan]
GO:0032675 [regulation of interleukin-6 production]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0033674 [positive regulation of kinase activity]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034151 [regulation of toll-like receptor 6 signaling pathway]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034189 [very-low-density lipoprotein particle binding]
GO:0034241 [positive regulation of macrophage fusion]
GO:0034351 [negative regulation of glial cell apoptotic process]
GO:0035176 [social behavior]
GO:0038023 [signaling receptor activity]
GO:0038160 [CXCL12-activated CXCR4 signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042834 [peptidoglycan binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043277 [apoptotic cell clearance]
GO:0044853 [plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045088 [regulation of innate immune response]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045728 [respiratory burst after phagocytosis]
GO:0045960 [positive regulation of complement activation, classical pathway]
GO:0048143 [astrocyte activation]
GO:0048678 [response to axon injury]
GO:0050714 [positive regulation of protein secretion]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050866 [negative regulation of cell activation]
GO:0050921 [positive regulation of chemotaxis]
GO:0055088 [lipid homeostasis]
GO:0060075 [regulation of resting membrane potential]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0061518 [microglial cell proliferation]
GO:0061889 [negative regulation of astrocyte activation]
GO:0070269 [pyroptosis]
GO:0070345 [negative regulation of fat cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070392 [detection of lipoteichoic acid]
GO:0070891 [lipoteichoic acid binding]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0071224 [cellular response to peptidoglycan]
GO:0071333 [cellular response to glucose stimulus]
GO:0071396 [cellular response to lipid]
GO:0071456 [cellular response to hypoxia]
GO:0071640 [regulation of macrophage inflammatory protein 1 alpha production]
GO:0071813 [lipoprotein particle binding]
GO:0097028 [dendritic cell differentiation]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0097242 [amyloid-beta clearance]
GO:0098657 [import into cell]
GO:0110089 [regulation of hippocampal neuron apoptotic process]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0120146 [sulfatide binding]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:0150062 [complement-mediated synapse pruning]
GO:0150076 [neuroinflammatory response]
GO:0150078 [positive regulation of neuroinflammatory response]
GO:0150079 [negative regulation of neuroinflammatory response]
GO:0150094 [amyloid-beta clearance by cellular catabolic process]
GO:1900015 [regulation of cytokine production involved in inflammatory response]
GO:1900016 [negative regulation of cytokine production involved in inflammatory response]
GO:1900223 [positive regulation of amyloid-beta clearance]
GO:1900226 [negative regulation of NLRP3 inflammasome complex assembly]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1901980 [positive regulation of inward rectifier potassium channel activity]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902531 [regulation of intracellular signal transduction]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903082 [positive regulation of C-C chemokine receptor CCR7 signaling pathway]
GO:1903376 [regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:1903980 [positive regulation of microglial cell activation]
GO:1904093 [negative regulation of autophagic cell death]
GO:1904141 [positive regulation of microglial cell migration]
GO:1904646 [cellular response to amyloid-beta]
GO:1904951 [positive regulation of establishment of protein localization]
GO:1905291 [positive regulation of CAMKK-AMPK signaling cascade]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905805 [excitatory synapse pruning]
GO:1905808 [positive regulation of synapse pruning]
GO:1905907 [negative regulation of amyloid fibril formation]
GO:1990782 [protein tyrosine kinase binding]
GO:2000350 [positive regulation of CD40 signaling pathway]
GO:2001171 [positive regulation of ATP biosynthetic process]
Show all
 230 aa
25.4 kDa 		Yes 1
TREM2-203
ENSP00000362214
ENST00000373122
Q9NZC2
[Direct mapping] Triggering receptor expressed on myeloid cells 2
Show all
Transporters
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Human disease related genes
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0001540 [amyloid-beta binding]
GO:0001774 [microglial cell activation]
GO:0001786 [phosphatidylserine binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002282 [microglial cell activation involved in immune response]
GO:0002588 [positive regulation of antigen processing and presentation of peptide antigen via MHC class II]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006910 [phagocytosis, recognition]
GO:0006959 [humoral immune response]
GO:0007613 [memory]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008289 [lipid binding]
GO:0008429 [phosphatidylethanolamine binding]
GO:0010468 [regulation of gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010822 [positive regulation of mitochondrion organization]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010891 [negative regulation of sequestering of triglyceride]
GO:0010983 [positive regulation of high-density lipoprotein particle clearance]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0019209 [kinase activator activity]
GO:0019216 [regulation of lipid metabolic process]
GO:0030169 [low-density lipoprotein particle binding]
GO:0030316 [osteoclast differentiation]
GO:0032006 [regulation of TOR signaling]
GO:0032008 [positive regulation of TOR signaling]
GO:0032675 [regulation of interleukin-6 production]
GO:0033674 [positive regulation of kinase activity]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0034151 [regulation of toll-like receptor 6 signaling pathway]
GO:0034185 [apolipoprotein binding]
GO:0034186 [apolipoprotein A-I binding]
GO:0034189 [very-low-density lipoprotein particle binding]
GO:0034241 [positive regulation of macrophage fusion]
GO:0034351 [negative regulation of glial cell apoptotic process]
GO:0035176 [social behavior]
GO:0038023 [signaling receptor activity]
GO:0038160 [CXCL12-activated CXCR4 signaling pathway]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043277 [apoptotic cell clearance]
GO:0044853 [plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045088 [regulation of innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0045960 [positive regulation of complement activation, classical pathway]
GO:0048143 [astrocyte activation]
GO:0048678 [response to axon injury]
GO:0050714 [positive regulation of protein secretion]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050766 [positive regulation of phagocytosis]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050866 [negative regulation of cell activation]
GO:0050921 [positive regulation of chemotaxis]
GO:0055088 [lipid homeostasis]
GO:0060075 [regulation of resting membrane potential]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0061518 [microglial cell proliferation]
GO:0061889 [negative regulation of astrocyte activation]
GO:0070269 [pyroptosis]
GO:0070345 [negative regulation of fat cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071396 [cellular response to lipid]
GO:0071640 [regulation of macrophage inflammatory protein 1 alpha production]
GO:0071813 [lipoprotein particle binding]
GO:0097028 [dendritic cell differentiation]
GO:0097062 [dendritic spine maintenance]
GO:0097110 [scaffold protein binding]
GO:0098657 [import into cell]
GO:0110089 [regulation of hippocampal neuron apoptotic process]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0120146 [sulfatide binding]
GO:0140052 [cellular response to oxidised low-density lipoprotein particle stimulus]
GO:0150062 [complement-mediated synapse pruning]
GO:0150079 [negative regulation of neuroinflammatory response]
GO:0150094 [amyloid-beta clearance by cellular catabolic process]
GO:1900015 [regulation of cytokine production involved in inflammatory response]
GO:1900016 [negative regulation of cytokine production involved in inflammatory response]
GO:1900223 [positive regulation of amyloid-beta clearance]
GO:1900226 [negative regulation of NLRP3 inflammasome complex assembly]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1901980 [positive regulation of inward rectifier potassium channel activity]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1902531 [regulation of intracellular signal transduction]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903082 [positive regulation of C-C chemokine receptor CCR7 signaling pathway]
GO:1903376 [regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903753 [negative regulation of p38MAPK cascade]
GO:1903980 [positive regulation of microglial cell activation]
GO:1904093 [negative regulation of autophagic cell death]
GO:1904141 [positive regulation of microglial cell migration]
GO:1904646 [cellular response to amyloid-beta]
GO:1904951 [positive regulation of establishment of protein localization]
GO:1905291 [positive regulation of CAMKK-AMPK signaling cascade]
GO:1905581 [positive regulation of low-density lipoprotein particle clearance]
GO:1905805 [excitatory synapse pruning]
GO:1905808 [positive regulation of synapse pruning]
GO:1905907 [negative regulation of amyloid fibril formation]
GO:1990782 [protein tyrosine kinase binding]
GO:2000350 [positive regulation of CD40 signaling pathway]
GO:2001171 [positive regulation of ATP biosynthetic process]
Show all
 222 aa
24.7 kDa 		Yes 0

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