GENERAL INFORMATIONi
Gene namei NRP1
Synonyms CD304, NRP, VEGF165R
Gene descriptioni Neuropilin 1
Protein classi Cancer-related genes
CD markers
Plasma proteins
Transporters
Predicted locationi Secreted, Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 10
Cytoband p11.22
Chromosome location (bp) 33177492 - 33336262
Number of transcriptsi 14
Ensembl ENSG00000099250 (version 109)
Entrez gene 8829
HGNC HGNC:8004
UniProt O14786 (UniProt - Evidence at protein level)
neXtProt NX_O14786
GeneCards NRP1
Antibodypedia NRP1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins 1, 2, 3. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage 4. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB 5, 6, 7, 8. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR 9. show less
Molecular function (UniProt)i Developmental protein, Heparin-binding, Receptor
Biological process (UniProt)i Angiogenesis, Differentiation, Host-virus interaction, Neurogenesis
Ligand (UniProt)i Calcium, Metal-binding
Gene summary (Entrez)i This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
NRP1-201
ENSP00000265371
ENST00000265371
O14786
[Direct mapping] Neuropilin-1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001755 [neural crest cell migration]
GO:0001764 [neuron migration]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002116 [semaphorin receptor complex]
GO:0003148 [outflow tract septum morphogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0019955 [cytokine binding]
GO:0021675 [nerve development]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030947 [regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031966 [mitochondrial membrane]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038023 [signaling receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038085 [vascular endothelial growth factor binding]
GO:0038189 [neuropilin signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0043542 [endothelial cell migration]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0048846 [axon extension involved in axon guidance]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060301 [positive regulation of cytokine activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0060978 [angiogenesis involved in coronary vascular morphogenesis]
GO:0061299 [retina vasculature morphogenesis in camera-type eye]
GO:0061549 [sympathetic ganglion development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071679 [commissural neuron axon guidance]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097102 [endothelial tip cell fate specification]
GO:0097443 [sorting endosome]
GO:0097475 [motor neuron migration]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0150018 [basal dendrite development]
GO:0150020 [basal dendrite arborization]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1902946 [protein localization to early endosome]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 923 aa
103.1 kDa 		Yes 1
NRP1-202
ENSP00000363949
ENST00000374816
E7EX60
[Direct mapping] Neuropilin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 641 aa
72.1 kDa 		Yes 0
NRP1-203
ENSP00000363954
ENST00000374821
O14786
[Direct mapping] Neuropilin-1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001755 [neural crest cell migration]
GO:0001764 [neuron migration]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002116 [semaphorin receptor complex]
GO:0003148 [outflow tract septum morphogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0019955 [cytokine binding]
GO:0021675 [nerve development]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030947 [regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031966 [mitochondrial membrane]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038023 [signaling receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038085 [vascular endothelial growth factor binding]
GO:0038189 [neuropilin signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0043542 [endothelial cell migration]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0048846 [axon extension involved in axon guidance]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060301 [positive regulation of cytokine activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0060978 [angiogenesis involved in coronary vascular morphogenesis]
GO:0061299 [retina vasculature morphogenesis in camera-type eye]
GO:0061549 [sympathetic ganglion development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071679 [commissural neuron axon guidance]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097102 [endothelial tip cell fate specification]
GO:0097443 [sorting endosome]
GO:0097475 [motor neuron migration]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0150018 [basal dendrite development]
GO:0150020 [basal dendrite arborization]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1902946 [protein localization to early endosome]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 609 aa
68.4 kDa 		Yes 0
NRP1-204
ENSP00000363955
ENST00000374822
O14786
[Direct mapping] Neuropilin-1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001755 [neural crest cell migration]
GO:0001764 [neuron migration]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002116 [semaphorin receptor complex]
GO:0003148 [outflow tract septum morphogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0019955 [cytokine binding]
GO:0021675 [nerve development]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030947 [regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031966 [mitochondrial membrane]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038023 [signaling receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038085 [vascular endothelial growth factor binding]
GO:0038189 [neuropilin signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0043542 [endothelial cell migration]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0048846 [axon extension involved in axon guidance]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060301 [positive regulation of cytokine activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0060978 [angiogenesis involved in coronary vascular morphogenesis]
GO:0061299 [retina vasculature morphogenesis in camera-type eye]
GO:0061549 [sympathetic ganglion development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071679 [commissural neuron axon guidance]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097102 [endothelial tip cell fate specification]
GO:0097443 [sorting endosome]
GO:0097475 [motor neuron migration]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0150018 [basal dendrite development]
GO:0150020 [basal dendrite arborization]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1902946 [protein localization to early endosome]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 644 aa
71.9 kDa 		Yes 0
NRP1-205
ENSP00000363956
ENST00000374823
Q5T7F0
[Direct mapping] Neuropilin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0030154 [cell differentiation]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 704 aa
79 kDa 		Yes 0
NRP1-206
ENSP00000364001
ENST00000374867
O14786
[Direct mapping] Neuropilin-1
Show all
CD markers
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001755 [neural crest cell migration]
GO:0001764 [neuron migration]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002116 [semaphorin receptor complex]
GO:0003148 [outflow tract septum morphogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005883 [neurofilament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007413 [axonal fasciculation]
GO:0007507 [heart development]
GO:0008045 [motor neuron axon guidance]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016358 [dendrite development]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0021612 [facial nerve structural organization]
GO:0021636 [trigeminal nerve morphogenesis]
GO:0021637 [trigeminal nerve structural organization]
GO:0021649 [vestibulocochlear nerve structural organization]
GO:0021675 [nerve development]
GO:0021785 [branchiomotor neuron axon guidance]
GO:0021828 [gonadotrophin-releasing hormone neuronal migration to the hypothalamus]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030517 [negative regulation of axon extension]
GO:0030947 [regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031966 [mitochondrial membrane]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036486 [ventral trunk neural crest cell migration]
GO:0038023 [signaling receptor activity]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038085 [vascular endothelial growth factor binding]
GO:0038189 [neuropilin signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042327 [positive regulation of phosphorylation]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043542 [endothelial cell migration]
GO:0045211 [postsynaptic membrane]
GO:0045766 [positive regulation of angiogenesis]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048485 [sympathetic nervous system development]
GO:0048666 [neuron development]
GO:0048675 [axon extension]
GO:0048841 [regulation of axon extension involved in axon guidance]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048843 [negative regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0048846 [axon extension involved in axon guidance]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060301 [positive regulation of cytokine activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0060666 [dichotomous subdivision of terminal units involved in salivary gland branching]
GO:0060978 [angiogenesis involved in coronary vascular morphogenesis]
GO:0060982 [coronary artery morphogenesis]
GO:0061299 [retina vasculature morphogenesis in camera-type eye]
GO:0061441 [renal artery morphogenesis]
GO:0061549 [sympathetic ganglion development]
GO:0061551 [trigeminal ganglion development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071679 [commissural neuron axon guidance]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097102 [endothelial tip cell fate specification]
GO:0097374 [sensory neuron axon guidance]
GO:0097443 [sorting endosome]
GO:0097475 [motor neuron migration]
GO:0097490 [sympathetic neuron projection extension]
GO:0097491 [sympathetic neuron projection guidance]
GO:0098978 [glutamatergic synapse]
GO:0099173 [postsynapse organization]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
GO:0150018 [basal dendrite development]
GO:0150020 [basal dendrite arborization]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1901998 [toxin transport]
GO:1902285 [semaphorin-plexin signaling pathway involved in neuron projection guidance]
GO:1902287 [semaphorin-plexin signaling pathway involved in axon guidance]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1902378 [VEGF-activated neuropilin signaling pathway involved in axon guidance]
GO:1902946 [protein localization to early endosome]
GO:1903375 [facioacoustic ganglion development]
GO:1904835 [dorsal root ganglion morphogenesis]
GO:1905040 [otic placode development]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 923 aa
103.1 kDa 		Yes 1
NRP1-207
ENSP00000364009
ENST00000374875
Q5JWQ6
[Direct mapping] Neuropilin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0009887 [animal organ morphogenesis]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0035767 [endothelial cell chemotaxis]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
Show all
 735 aa
82 kDa 		No 1
NRP1-208
ENSP00000379317
ENST00000395995
E9PEP6
[Direct mapping] Neuropilin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0009887 [animal organ morphogenesis]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0030154 [cell differentiation]
GO:0035767 [endothelial cell chemotaxis]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0120035 [regulation of plasma membrane bounded cell projection organization]
Show all
 906 aa
101.3 kDa 		Yes 1
NRP1-209
ENSP00000390447
ENST00000413802
Q5JWQ2
[Direct mapping] Neuropilin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007411 [axon guidance]
GO:0009887 [animal organ morphogenesis]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0035767 [endothelial cell chemotaxis]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 105 aa
11.4 kDa 		No 1
NRP1-210
ENSP00000416147
ENST00000418675
H0Y7Z2
[Direct mapping] Neuropilin-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007411 [axon guidance]
GO:0009887 [animal organ morphogenesis]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0035767 [endothelial cell chemotaxis]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 77 aa
7.9 kDa 		No 0
NRP1-211
ENSP00000393071
ENST00000431894
H0Y4N6
[Direct mapping] Neuropilin-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007411 [axon guidance]
GO:0009887 [animal organ morphogenesis]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0035767 [endothelial cell chemotaxis]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 100 aa
10.6 kDa 		No 0
NRP1-212
ENSP00000408911
ENST00000432372
Q5JWQ4
[Direct mapping] Neuropilin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 597 aa
67.3 kDa 		Yes 0
NRP1-213
ENSP00000390567
ENST00000455749
H0Y4A0
[Direct mapping] Neuropilin-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 170 aa
19 kDa 		No 0
NRP1-214
ENSP00000476896
ENST00000466932
V9GYL7
[Direct mapping] Neuropilin-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005021 [vascular endothelial growth factor receptor activity]
GO:0007411 [axon guidance]
GO:0009887 [animal organ morphogenesis]
GO:0016020 [membrane]
GO:0017154 [semaphorin receptor activity]
GO:0019838 [growth factor binding]
GO:0035767 [endothelial cell chemotaxis]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
 60 aa
6.9 kDa 		No 0

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