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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q11.21
Chromosome location (bp)
20917407 - 20953747
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May mediate the transduction of intracellular signals....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558[regulation of cell growth] GO:0001568[blood vessel development] GO:0001655[urogenital system development] GO:0001764[neuron migration] GO:0001783[B cell apoptotic process] GO:0001784[phosphotyrosine residue binding] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0002685[regulation of leukocyte migration] GO:0003151[outflow tract morphogenesis] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007254[JNK cascade] GO:0007265[Ras protein signal transduction] GO:0007283[spermatogenesis] GO:0007338[single fertilization] GO:0007389[pattern specification process] GO:0007507[heart development] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0008584[male gonad development] GO:0009887[animal organ morphogenesis] GO:0009952[anterior/posterior pattern specification] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016358[dendrite development] GO:0016477[cell migration] GO:0021766[hippocampus development] GO:0021987[cerebral cortex development] GO:0030010[establishment of cell polarity] GO:0030971[receptor tyrosine kinase binding] GO:0031594[neuromuscular junction] GO:0032991[protein-containing complex] GO:0033628[regulation of cell adhesion mediated by integrin] GO:0035556[intracellular signal transduction] GO:0035591[signaling adaptor activity] GO:0035685[helper T cell diapedesis] GO:0038026[reelin-mediated signaling pathway] GO:0042802[identical protein binding] GO:0043410[positive regulation of MAPK cascade] GO:0045202[synapse] GO:0045296[cadherin binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048538[thymus development] GO:0050773[regulation of dendrite development] GO:0050852[T cell receptor signaling pathway] GO:0060017[parathyroid gland development] GO:0060326[cell chemotaxis] GO:0060465[pharynx development] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071466[cellular response to xenobiotic stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0071774[response to fibroblast growth factor] GO:0086100[endothelin receptor signaling pathway] GO:0090630[activation of GTPase activity] GO:0095500[acetylcholine receptor signaling pathway] GO:0098698[postsynaptic specialization assembly] GO:0098749[cerebellar neuron development] GO:0098761[cellular response to interleukin-7] GO:0098890[extrinsic component of postsynaptic membrane] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1903977[positive regulation of glial cell migration] GO:1904393[regulation of skeletal muscle acetylcholine-gated channel clustering] GO:1904888[cranial skeletal system development] GO:2000404[regulation of T cell migration]
The Human Protein Atlas project is funded
