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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q11.22
Chromosome location (bp)
21919425 - 21952848
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Magnesium, Manganese, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005829[cytosol] GO:0006469[negative regulation of protein kinase activity] GO:0006470[protein dephosphorylation] GO:0006915[apoptotic process] GO:0008138[protein tyrosine/serine/threonine phosphatase activity] GO:0010628[positive regulation of gene expression] GO:0010634[positive regulation of epithelial cell migration] GO:0010811[positive regulation of cell-substrate adhesion] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0030335[positive regulation of cell migration] GO:0032880[regulation of protein localization] GO:0032991[protein-containing complex] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0033192[calmodulin-dependent protein phosphatase activity] GO:0035970[peptidyl-threonine dephosphorylation] GO:0043169[cation binding] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045927[positive regulation of growth] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050921[positive regulation of chemotaxis] GO:0051224[negative regulation of protein transport] GO:0051496[positive regulation of stress fiber assembly] GO:0051894[positive regulation of focal adhesion assembly] GO:0070262[peptidyl-serine dephosphorylation] GO:0071466[cellular response to xenobiotic stimulus] GO:0097193[intrinsic apoptotic signaling pathway] GO:2000048[negative regulation of cell-cell adhesion mediated by cadherin]
A8MX49 [Direct mapping] Protein phosphatase 1F; Protein phosphatase 1F (PP2C domain containing), isoform CRA_b
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
B5MCT7 [Direct mapping] Protein phosphatase 1F; Protein phosphatase 1F (PP2C domain containing), isoform CRA_a
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
