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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q12.1
Chromosome location (bp)
26491225 - 26512505
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Biomineralization, mRNA processing, mRNA splicing
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9UBB9 [Direct mapping] Tuftelin-interacting protein 11
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A0A024R1I7 [Target identity:100%; Query identity:100%] Tuftelin-interacting protein 11
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MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000390[spliceosomal complex disassembly] GO:0000398[mRNA splicing, via spliceosome] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006396[RNA processing] GO:0006397[mRNA processing] GO:0006807[nitrogen compound metabolic process] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031214[biomineral tissue development] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031848[protection from non-homologous end joining at telomere] GO:0032091[negative regulation of protein binding] GO:0043170[macromolecule metabolic process] GO:0044238[primary metabolic process] GO:0071008[U2-type post-mRNA release spliceosomal complex] GO:0071013[catalytic step 2 spliceosome] GO:1904876[negative regulation of DNA ligase activity] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
Q9UBB9 [Direct mapping] Tuftelin-interacting protein 11
Show all
A0A024R1I7 [Target identity:100%; Query identity:100%] Tuftelin-interacting protein 11
Show all
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000390[spliceosomal complex disassembly] GO:0000398[mRNA splicing, via spliceosome] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006396[RNA processing] GO:0006397[mRNA processing] GO:0006807[nitrogen compound metabolic process] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031214[biomineral tissue development] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031848[protection from non-homologous end joining at telomere] GO:0032091[negative regulation of protein binding] GO:0043170[macromolecule metabolic process] GO:0044238[primary metabolic process] GO:0071008[U2-type post-mRNA release spliceosomal complex] GO:0071013[catalytic step 2 spliceosome] GO:1904876[negative regulation of DNA ligase activity] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
Q9UBB9 [Direct mapping] Tuftelin-interacting protein 11
Show all
A0A024R1I7 [Target identity:100%; Query identity:100%] Tuftelin-interacting protein 11
Show all
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000390[spliceosomal complex disassembly] GO:0000398[mRNA splicing, via spliceosome] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006396[RNA processing] GO:0006397[mRNA processing] GO:0006807[nitrogen compound metabolic process] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031214[biomineral tissue development] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031848[protection from non-homologous end joining at telomere] GO:0032091[negative regulation of protein binding] GO:0043170[macromolecule metabolic process] GO:0044238[primary metabolic process] GO:0071008[U2-type post-mRNA release spliceosomal complex] GO:0071013[catalytic step 2 spliceosome] GO:1904876[negative regulation of DNA ligase activity] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
Q9UBB9 [Direct mapping] Tuftelin-interacting protein 11
Show all
A0A024R1I7 [Target identity:100%; Query identity:100%] Tuftelin-interacting protein 11
Show all
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000390[spliceosomal complex disassembly] GO:0000398[mRNA splicing, via spliceosome] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006396[RNA processing] GO:0006397[mRNA processing] GO:0006807[nitrogen compound metabolic process] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031012[extracellular matrix] GO:0031214[biomineral tissue development] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031848[protection from non-homologous end joining at telomere] GO:0032091[negative regulation of protein binding] GO:0043170[macromolecule metabolic process] GO:0044238[primary metabolic process] GO:0071008[U2-type post-mRNA release spliceosomal complex] GO:0071013[catalytic step 2 spliceosome] GO:1904876[negative regulation of DNA ligase activity] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
Q9UBB9 [Direct mapping] Tuftelin-interacting protein 11
Show all
A0A024R1I7 [Target identity:100%; Query identity:100%] Tuftelin-interacting protein 11
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000390[spliceosomal complex disassembly] GO:0000398[mRNA splicing, via spliceosome] GO:0000781[chromosome, telomeric region] GO:0003676[nucleic acid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0006396[RNA processing] GO:0006397[mRNA processing] GO:0006807[nitrogen compound metabolic process] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031214[biomineral tissue development] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031848[protection from non-homologous end joining at telomere] GO:0032091[negative regulation of protein binding] GO:0043170[macromolecule metabolic process] GO:0044238[primary metabolic process] GO:0071008[U2-type post-mRNA release spliceosomal complex] GO:0071013[catalytic step 2 spliceosome] GO:1904876[negative regulation of DNA ligase activity] GO:2001033[negative regulation of double-strand break repair via nonhomologous end joining]
The Human Protein Atlas project is funded
