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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.2
Chromosome location (bp)
96363452 - 96387288
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets 1,2,3. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively 4,5. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B 6. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression 7....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0019207[kinase regulator activity] GO:0019901[protein kinase binding] GO:0030111[regulation of Wnt signaling pathway] GO:0034237[protein kinase A regulatory subunit binding] GO:0051018[protein kinase A binding] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0019207[kinase regulator activity] GO:0019901[protein kinase binding] GO:0030111[regulation of Wnt signaling pathway] GO:0034237[protein kinase A regulatory subunit binding] GO:0051018[protein kinase A binding] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0019207[kinase regulator activity] GO:0019901[protein kinase binding] GO:0030111[regulation of Wnt signaling pathway] GO:0034237[protein kinase A regulatory subunit binding] GO:0051018[protein kinase A binding] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0008631[intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0019207[kinase regulator activity] GO:0019901[protein kinase binding] GO:0030111[regulation of Wnt signaling pathway] GO:0034237[protein kinase A regulatory subunit binding] GO:0051018[protein kinase A binding] GO:0060828[regulation of canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway]
The Human Protein Atlas project is funded
