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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.12
Chromosome location (bp)
47209214 - 47356889
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) 1,2,3,4. May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac 5. May also act as a transcriptional corepressor for KDM5C and EZH2 6. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination 7,8,9. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters 10,11. Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression 12. Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform 13,14,15. Suppresses breast cancer, and prostate cancer cell invasion and metastasis 16,17,18....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
Q9ULU4 [Direct mapping] Protein kinase C-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000724[double-strand break repair via homologous recombination] GO:0000785[chromatin] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0006355[regulation of DNA-templated transcription] GO:0007399[nervous system development] GO:0008270[zinc ion binding] GO:0019904[protein domain specific binding] GO:0030336[negative regulation of cell migration] GO:0032968[positive regulation of transcription elongation by RNA polymerase II] GO:0035064[methylated histone binding] GO:0046872[metal ion binding] GO:0070577[lysine-acetylated histone binding] GO:0071168[protein localization to chromatin] GO:0090734[site of DNA damage] GO:0140297[DNA-binding transcription factor binding]
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