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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q14.11
Chromosome location (bp)
41457550 - 41470871
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9H4X1 [Direct mapping] Regulator of cell cycle RGCC
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Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001100[negative regulation of exit from mitosis] GO:0001818[negative regulation of cytokine production] GO:0001819[positive regulation of cytokine production] GO:0001937[negative regulation of endothelial cell proliferation] GO:0003331[positive regulation of extracellular matrix constituent secretion] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006956[complement activation] GO:0007049[cell cycle] GO:0008285[negative regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016525[negative regulation of angiogenesis] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0032967[positive regulation of collagen biosynthetic process] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045840[positive regulation of mitotic nuclear division] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051496[positive regulation of stress fiber assembly] GO:0051726[regulation of cell cycle] GO:0070412[R-SMAD binding] GO:0071456[cellular response to hypoxia] GO:0072537[fibroblast activation] GO:0090272[negative regulation of fibroblast growth factor production] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1901203[positive regulation of extracellular matrix assembly] GO:1901991[negative regulation of mitotic cell cycle phase transition] GO:2000048[negative regulation of cell-cell adhesion mediated by cadherin] GO:2000353[positive regulation of endothelial cell apoptotic process] GO:2000573[positive regulation of DNA biosynthetic process]
The Human Protein Atlas project is funded
