GENERAL INFORMATIONi
Gene namei DNAJA3
Synonyms hTid-1, TID1
Gene descriptioni DnaJ heat shock protein family (Hsp40) member A3
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 16
Cytoband p13.3
Chromosome location (bp) 4425805 - 4456775
Number of transcriptsi 4
Ensembl ENSG00000103423 (version 109)
Entrez gene 9093
HGNC HGNC:11808
UniProt Q96EY1 (UniProt - Evidence at protein level)
neXtProt NX_Q96EY1
GeneCards DNAJA3
Antibodypedia DNAJA3 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. show less
Molecular function (UniProt)i Chaperone
Biological process (UniProt)i Apoptosis
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
DNAJA3-201
ENSP00000262375
ENST00000262375
Q96EY1
[Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
Show all
Q53G26
[Target identity:100%; Query identity:100%] DnaJ (Hsp40) homolog, subfamily A, member 3 variant; DnaJ (Hsp40) homolog, subfamily A, member 3, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0005133 [interferon-gamma receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006264 [mitochondrial DNA replication]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006924 [activation-induced cell death of T cells]
GO:0007005 [mitochondrion organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007528 [neuromuscular junction development]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009408 [response to heat]
GO:0016020 [membrane]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030544 [Hsp70 protein binding]
GO:0030695 [GTPase regulator activity]
GO:0031072 [heat shock protein binding]
GO:0031594 [neuromuscular junction]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0033077 [T cell differentiation in thymus]
GO:0034341 [response to type II interferon]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042645 [mitochondrial nucleoid]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044877 [protein-containing complex binding]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0050821 [protein stabilization]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
GO:0090398 [cellular senescence]
GO:0106137 [IkappaB kinase complex binding]
GO:0140297 [DNA-binding transcription factor binding]
Show all
 480 aa
52.5 kDa 		No 0
DNAJA3-202
ENSP00000347445
ENST00000355296
Q96EY1
[Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0005133 [interferon-gamma receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006915 [apoptotic process]
GO:0007005 [mitochondrion organization]
GO:0007528 [neuromuscular junction development]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009408 [response to heat]
GO:0016020 [membrane]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019901 [protein kinase binding]
GO:0031072 [heat shock protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031594 [neuromuscular junction]
GO:0034341 [response to type II interferon]
GO:0042645 [mitochondrial nucleoid]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044877 [protein-containing complex binding]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
GO:0106137 [IkappaB kinase complex binding]
Show all
 453 aa
49.6 kDa 		No 0
DNAJA3-203
ENSP00000393970
ENST00000431375
Q96EY1
[Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006915 [apoptotic process]
GO:0007005 [mitochondrion organization]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009408 [response to heat]
GO:0016020 [membrane]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019901 [protein kinase binding]
GO:0031072 [heat shock protein binding]
GO:0031594 [neuromuscular junction]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046872 [metal ion binding]
GO:0051082 [unfolded protein binding]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
Show all
 300 aa
33.1 kDa 		No 0
DNAJA3-210
ENSP00000459088
ENST00000574895
I3L1T6
[Direct mapping] DnaJ homolog subfamily A member 3, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 185 aa
20.4 kDa 		No 0

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