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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q13.1
Chromosome location (bp)
29699367 - 29968915
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton 1,2. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells 3. Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling 4. With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q07157 [Direct mapping] Tight junction protein ZO-1
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002102[podosome] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005921[gap junction] GO:0005923[bicellular tight junction] GO:0007043[cell-cell junction assembly] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0030054[cell junction] GO:0030335[positive regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032991[protein-containing complex] GO:0034334[adherens junction maintenance] GO:0035633[maintenance of blood-brain barrier] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043296[apical junction complex] GO:0045177[apical part of cell] GO:0045216[cell-cell junction organization] GO:0045296[cadherin binding] GO:0050839[cell adhesion molecule binding] GO:0051493[regulation of cytoskeleton organization] GO:0051497[negative regulation of stress fiber assembly] GO:0070160[tight junction] GO:0070161[anchoring junction] GO:0071896[protein localization to adherens junction] GO:0090557[establishment of endothelial intestinal barrier] GO:0098609[cell-cell adhesion] GO:0150105[protein localization to cell-cell junction] GO:1901888[regulation of cell junction assembly] GO:1902396[protein localization to bicellular tight junction] GO:1903672[positive regulation of sprouting angiogenesis] GO:1905605[positive regulation of blood-brain barrier permeability] GO:2000049[positive regulation of cell-cell adhesion mediated by cadherin] GO:2000250[negative regulation of actin cytoskeleton reorganization] GO:2000810[regulation of bicellular tight junction assembly]
G3V1L9 [Direct mapping] Tight junction protein ZO-1
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Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Q07157 [Direct mapping] Tight junction protein ZO-1
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102[podosome] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005921[gap junction] GO:0005923[bicellular tight junction] GO:0007043[cell-cell junction assembly] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016323[basolateral plasma membrane] GO:0030054[cell junction] GO:0030335[positive regulation of cell migration] GO:0031032[actomyosin structure organization] GO:0032991[protein-containing complex] GO:0034334[adherens junction maintenance] GO:0035633[maintenance of blood-brain barrier] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043296[apical junction complex] GO:0045177[apical part of cell] GO:0045216[cell-cell junction organization] GO:0045296[cadherin binding] GO:0050839[cell adhesion molecule binding] GO:0051493[regulation of cytoskeleton organization] GO:0051497[negative regulation of stress fiber assembly] GO:0070160[tight junction] GO:0070161[anchoring junction] GO:0071896[protein localization to adherens junction] GO:0090557[establishment of endothelial intestinal barrier] GO:0098609[cell-cell adhesion] GO:0150105[protein localization to cell-cell junction] GO:1901888[regulation of cell junction assembly] GO:1902396[protein localization to bicellular tight junction] GO:1903672[positive regulation of sprouting angiogenesis] GO:1905605[positive regulation of blood-brain barrier permeability] GO:2000049[positive regulation of cell-cell adhesion mediated by cadherin] GO:2000250[negative regulation of actin cytoskeleton reorganization] GO:2000810[regulation of bicellular tight junction assembly]
The Human Protein Atlas project is funded
