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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.33
Chromosome location (bp)
47745546 - 47757058
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis 1. In ribosome biogenesis, may also play a role in rRNA transcription 2. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions 3,4,5. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation 6,7. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation 8. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway 9,10,11. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 12. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation 13. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex 14. May also regulate cellular aerobic respiration 15. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI 16....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Ribosome biogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of cellular protein metabolic process; and regulation of intracellular signal transduction. Located in cytosol; fibrillar center; and nucleoplasm. Colocalizes with rDNA heterochromatin. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9NZM5 [Direct mapping] Ribosome biogenesis protein NOP53
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000027[ribosomal large subunit assembly] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001650[fibrillar center] GO:0001932[regulation of protein phosphorylation] GO:0002039[p53 binding] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006364[rRNA processing] GO:0006974[cellular response to DNA damage stimulus] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0008097[5S rRNA binding] GO:0014067[negative regulation of phosphatidylinositol 3-kinase signaling] GO:0031333[negative regulation of protein-containing complex assembly] GO:0032435[negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0033553[rDNA heterochromatin] GO:0039535[regulation of RIG-I signaling pathway] GO:0042254[ribosome biogenesis] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0050821[protein stabilization] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0071456[cellular response to hypoxia] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1901797[negative regulation of signal transduction by p53 class mediator] GO:1901837[negative regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902570[protein localization to nucleolus] GO:1903006[positive regulation of protein K63-linked deubiquitination] GO:1903715[regulation of aerobic respiration] GO:1990173[protein localization to nucleoplasm]
The Human Protein Atlas project is funded
