GENERAL INFORMATIONi
Gene namei CAV1
Synonyms CAV
Gene descriptioni Caveolin 1
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Potential drug targets
Transporters
Predicted locationi Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 7
Cytoband q31.2
Chromosome location (bp) 116524994 - 116561179
Number of transcriptsi 7
Ensembl ENSG00000105974 (version 109)
Entrez gene 857
HGNC HGNC:1527
UniProt Q03135 (UniProt - Evidence at protein level)
neXtProt NX_Q03135
GeneCards CAV1
Antibodypedia CAV1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i May act as a scaffolding protein within caveolar membranes 1. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae 2. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner 3. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation 4. show less
Biological process (UniProt)i Host-virus interaction
Gene summary (Entrez)i The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CAV1-201
ENSP00000339191
ENST00000341049
Q03135
[Direct mapping] Caveolin-1
Show all
Q2TNI1
[Target identity:100%; Query identity:100%] Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001935 [endothelial cell proliferation]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002026 [regulation of the force of heart contraction]
GO:0002067 [glandular epithelial cell differentiation]
GO:0002080 [acrosomal membrane]
GO:0002095 [caveolar macromolecular signaling complex]
GO:0002931 [response to ischemia]
GO:0003057 [regulation of the force of heart contraction by chemical signal]
GO:0005102 [signaling receptor binding]
GO:0005113 [patched binding]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0005938 [cell cortex]
GO:0006641 [triglyceride metabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007519 [skeletal muscle tissue development]
GO:0007595 [lactation]
GO:0008104 [protein localization]
GO:0008283 [cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009617 [response to bacterium]
GO:0009968 [negative regulation of signal transduction]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010608 [post-transcriptional regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0015031 [protein transport]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031267 [small GTPase binding]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032991 [protein-containing complex]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0038016 [insulin receptor internalization]
GO:0042310 [vasoconstriction]
GO:0042383 [sarcolemma]
GO:0042532 [negative regulation of tyrosine phosphorylation of STAT protein]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044325 [transmembrane transporter binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046426 [negative regulation of receptor signaling pathway via JAK-STAT]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046982 [protein heterodimerization activity]
GO:0048144 [fibroblast proliferation]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051117 [ATPase binding]
GO:0051480 [regulation of cytosolic calcium ion concentration]
GO:0051592 [response to calcium ion]
GO:0051649 [establishment of localization in cell]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060090 [molecular adaptor activity]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0060546 [negative regulation of necroptotic process]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071711 [basement membrane organization]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903609 [negative regulation of inward rectifier potassium channel activity]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 178 aa
20.5 kDa 		No 1
CAV1-202
ENSP00000377110
ENST00000393467
Q03135
[Direct mapping] Caveolin-1
Show all
A0A024R757
[Target identity:100%; Query identity:100%] Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000139 [Golgi membrane]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [signaling receptor binding]
GO:0005113 [patched binding]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031267 [small GTPase binding]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032991 [protein-containing complex]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042383 [sarcolemma]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044325 [transmembrane transporter binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046426 [negative regulation of receptor signaling pathway via JAK-STAT]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051117 [ATPase binding]
GO:0051480 [regulation of cytosolic calcium ion concentration]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060090 [molecular adaptor activity]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903609 [negative regulation of inward rectifier potassium channel activity]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 147 aa
17 kDa 		No 1
CAV1-203
ENSP00000377111
ENST00000393468
Q03135
[Direct mapping] Caveolin-1
Show all
A0A024R757
[Target identity:100%; Query identity:100%] Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000139 [Golgi membrane]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [signaling receptor binding]
GO:0005113 [patched binding]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031267 [small GTPase binding]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032991 [protein-containing complex]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042383 [sarcolemma]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044325 [transmembrane transporter binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046426 [negative regulation of receptor signaling pathway via JAK-STAT]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051117 [ATPase binding]
GO:0051480 [regulation of cytosolic calcium ion concentration]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060090 [molecular adaptor activity]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903609 [negative regulation of inward rectifier potassium channel activity]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 147 aa
17 kDa 		No 1
CAV1-204
ENSP00000377113
ENST00000393470
E9PCT5
[Direct mapping] Caveolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0016020 [membrane]
GO:0045121 [membrane raft]
GO:0070836 [caveola assembly]
Show all
 167 aa
19.2 kDa 		No 1
CAV1-205
ENSP00000384348
ENST00000405348
Q03135
[Direct mapping] Caveolin-1
Show all
A0A024R757
[Target identity:100%; Query identity:100%] Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000139 [Golgi membrane]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [signaling receptor binding]
GO:0005113 [patched binding]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid droplet]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031267 [small GTPase binding]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032991 [protein-containing complex]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042383 [sarcolemma]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044325 [transmembrane transporter binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0044877 [protein-containing complex binding]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046426 [negative regulation of receptor signaling pathway via JAK-STAT]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051117 [ATPase binding]
GO:0051480 [regulation of cytosolic calcium ion concentration]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060090 [molecular adaptor activity]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903609 [negative regulation of inward rectifier potassium channel activity]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 147 aa
17 kDa 		No 1
CAV1-207
ENSP00000389033
ENST00000456473
C9JKI3
[Direct mapping] Caveolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0016020 [membrane]
GO:0045121 [membrane raft]
GO:0070836 [caveola assembly]
Show all
 138 aa
15.9 kDa 		No 1
CAV1-209
ENSP00000479447
ENST00000614113
A0A7P0YWJ6
[Direct mapping] Caveolin-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Hypertensive diseases
   Congenital disorders of metabolism
   Other congenital disorders of metabolism
Protein evidence (Ezkurdia et al 2014)
Show all
 115 aa
12.4 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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