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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q31.2
Chromosome location (bp)
116672196 - 116798377
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001886[endothelial cell morphogenesis] GO:0001889[liver development] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005008[hepatocyte growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006909[phagocytosis] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017154[semaphorin receptor activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019903[protein phosphatase binding] GO:0030182[neuron differentiation] GO:0031016[pancreas development] GO:0031116[positive regulation of microtubule polymerization] GO:0033674[positive regulation of kinase activity] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042802[identical protein binding] GO:0043235[receptor complex] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0048754[branching morphogenesis of an epithelial tube] GO:0050918[positive chemotaxis] GO:0051497[negative regulation of stress fiber assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0061436[establishment of skin barrier] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:0071526[semaphorin-plexin signaling pathway] GO:0140677[molecular function activator activity] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity] GO:2001028[positive regulation of endothelial cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001886[endothelial cell morphogenesis] GO:0001889[liver development] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005008[hepatocyte growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006909[phagocytosis] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017154[semaphorin receptor activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019903[protein phosphatase binding] GO:0030182[neuron differentiation] GO:0031016[pancreas development] GO:0031116[positive regulation of microtubule polymerization] GO:0033674[positive regulation of kinase activity] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042802[identical protein binding] GO:0043235[receptor complex] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0048754[branching morphogenesis of an epithelial tube] GO:0050918[positive chemotaxis] GO:0051497[negative regulation of stress fiber assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0061436[establishment of skin barrier] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:0071526[semaphorin-plexin signaling pathway] GO:0140677[molecular function activator activity] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity] GO:2001028[positive regulation of endothelial cell chemotaxis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Transporters Accessory Factors Involved in Transport Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001886[endothelial cell morphogenesis] GO:0001889[liver development] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005008[hepatocyte growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006909[phagocytosis] GO:0007165[signal transduction] GO:0007166[cell surface receptor signaling pathway] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007399[nervous system development] GO:0009925[basal plasma membrane] GO:0009986[cell surface] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017154[semaphorin receptor activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019903[protein phosphatase binding] GO:0030182[neuron differentiation] GO:0031016[pancreas development] GO:0031116[positive regulation of microtubule polymerization] GO:0033674[positive regulation of kinase activity] GO:0035024[negative regulation of Rho protein signal transduction] GO:0042802[identical protein binding] GO:0043235[receptor complex] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048012[hepatocyte growth factor receptor signaling pathway] GO:0048754[branching morphogenesis of an epithelial tube] GO:0050918[positive chemotaxis] GO:0051497[negative regulation of stress fiber assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0061436[establishment of skin barrier] GO:0070495[negative regulation of thrombin-activated receptor signaling pathway] GO:0071526[semaphorin-plexin signaling pathway] GO:0140677[molecular function activator activity] GO:1901299[negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1905098[negative regulation of guanyl-nucleotide exchange factor activity] GO:2001028[positive regulation of endothelial cell chemotaxis]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
