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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q22.1
Chromosome location (bp)
101127104 - 101139247
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine protease inhibitor. Inhibits TMPRSS7 1. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots 2,3,4. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading 5. Acts as a regulator of cell migration, independently of its role as protease inhibitor 6,7. It is required for stimulation of keratinocyte migration during cutaneous injury repair 8. It is involved in cellular and replicative senescence 9. Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis 10,11....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protease inhibitor, Serine protease inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A0A024QYT5 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 1, isoform CRA_b
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SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Cardiovascular diseases Hematologic diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0002020[protease binding] GO:0004867[serine-type endopeptidase inhibitor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0010466[negative regulation of peptidase activity] GO:0010469[regulation of signaling receptor activity] GO:0010757[negative regulation of plasminogen activation] GO:0010951[negative regulation of endopeptidase activity] GO:0014912[negative regulation of smooth muscle cell migration] GO:0030194[positive regulation of blood coagulation] GO:0030195[negative regulation of blood coagulation] GO:0030336[negative regulation of cell migration] GO:0030414[peptidase inhibitor activity] GO:0031093[platelet alpha granule lumen] GO:0032757[positive regulation of interleukin-8 production] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0035491[positive regulation of leukotriene production involved in inflammatory response] GO:0042730[fibrinolysis] GO:0045766[positive regulation of angiogenesis] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0050729[positive regulation of inflammatory response] GO:0050829[defense response to Gram-negative bacterium] GO:0051918[negative regulation of fibrinolysis] GO:0061044[negative regulation of vascular wound healing] GO:0061045[negative regulation of wound healing] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071222[cellular response to lipopolysaccharide] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090399[replicative senescence] GO:0097180[serine protease inhibitor complex] GO:0097187[dentinogenesis] GO:1901331[positive regulation of odontoblast differentiation] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1904090[peptidase inhibitor complex] GO:2000098[negative regulation of smooth muscle cell-matrix adhesion] GO:2000352[negative regulation of endothelial cell apoptotic process]
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