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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q11.21
Chromosome location (bp)
44370165 - 44386493
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner 1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Growth factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chemotaxis, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666[response to hypoxia] GO:0001764[neuron migration] GO:0001938[positive regulation of endothelial cell proliferation] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006874[cellular calcium ion homeostasis] GO:0006935[chemotaxis] GO:0006952[defense response] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007411[axon guidance] GO:0007420[brain development] GO:0008009[chemokine activity] GO:0008015[blood circulation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0008344[adult locomotory behavior] GO:0009314[response to radiation] GO:0009408[response to heat] GO:0009605[response to external stimulus] GO:0009612[response to mechanical stimulus] GO:0009615[response to virus] GO:0009897[external side of plasma membrane] GO:0022029[telencephalon cell migration] GO:0030335[positive regulation of cell migration] GO:0031100[animal organ regeneration] GO:0033603[positive regulation of dopamine secretion] GO:0033622[integrin activation] GO:0038146[chemokine (C-X-C motif) ligand 12 signaling pathway] GO:0042379[chemokine receptor binding] GO:0043434[response to peptide hormone] GO:0045236[CXCR chemokine receptor binding] GO:0045666[positive regulation of neuron differentiation] GO:0045785[positive regulation of cell adhesion] GO:0048842[positive regulation of axon extension involved in axon guidance] GO:0050930[induction of positive chemotaxis] GO:0050965[detection of temperature stimulus involved in sensory perception of pain] GO:0050966[detection of mechanical stimulus involved in sensory perception of pain] GO:0051924[regulation of calcium ion transport] GO:0060326[cell chemotaxis] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070098[chemokine-mediated signaling pathway] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090280[positive regulation of calcium ion import] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1903237[negative regulation of leukocyte tethering or rolling] GO:1990478[response to ultrasound] GO:1990869[cellular response to chemokine] GO:2000406[positive regulation of T cell migration] GO:2000669[negative regulation of dendritic cell apoptotic process]
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006874[cellular calcium ion homeostasis] GO:0006935[chemotaxis] GO:0006952[defense response] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007411[axon guidance] GO:0008009[chemokine activity] GO:0008015[blood circulation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008083[growth factor activity] GO:0009605[response to external stimulus] GO:0009615[response to virus] GO:0009897[external side of plasma membrane] GO:0030335[positive regulation of cell migration] GO:0033622[integrin activation] GO:0038146[chemokine (C-X-C motif) ligand 12 signaling pathway] GO:0042379[chemokine receptor binding] GO:0045236[CXCR chemokine receptor binding] GO:0045785[positive regulation of cell adhesion] GO:0050930[induction of positive chemotaxis] GO:0060326[cell chemotaxis] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070098[chemokine-mediated signaling pathway] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090280[positive regulation of calcium ion import] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1903237[negative regulation of leukocyte tethering or rolling] GO:1990869[cellular response to chemokine] GO:2000406[positive regulation of T cell migration] GO:2000669[negative regulation of dendritic cell apoptotic process]
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006874[cellular calcium ion homeostasis] GO:0006935[chemotaxis] GO:0006952[defense response] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007411[axon guidance] GO:0008009[chemokine activity] GO:0008015[blood circulation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008083[growth factor activity] GO:0009605[response to external stimulus] GO:0009615[response to virus] GO:0009897[external side of plasma membrane] GO:0030335[positive regulation of cell migration] GO:0033622[integrin activation] GO:0038146[chemokine (C-X-C motif) ligand 12 signaling pathway] GO:0042379[chemokine receptor binding] GO:0045236[CXCR chemokine receptor binding] GO:0045785[positive regulation of cell adhesion] GO:0050930[induction of positive chemotaxis] GO:0060326[cell chemotaxis] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070098[chemokine-mediated signaling pathway] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090280[positive regulation of calcium ion import] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1903237[negative regulation of leukocyte tethering or rolling] GO:1990869[cellular response to chemokine] GO:2000406[positive regulation of T cell migration] GO:2000669[negative regulation of dendritic cell apoptotic process]
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006874[cellular calcium ion homeostasis] GO:0006935[chemotaxis] GO:0006952[defense response] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007411[axon guidance] GO:0008009[chemokine activity] GO:0008015[blood circulation] GO:0008064[regulation of actin polymerization or depolymerization] GO:0008083[growth factor activity] GO:0009605[response to external stimulus] GO:0009615[response to virus] GO:0009897[external side of plasma membrane] GO:0030335[positive regulation of cell migration] GO:0033622[integrin activation] GO:0038146[chemokine (C-X-C motif) ligand 12 signaling pathway] GO:0042379[chemokine receptor binding] GO:0045236[CXCR chemokine receptor binding] GO:0045785[positive regulation of cell adhesion] GO:0050930[induction of positive chemotaxis] GO:0060326[cell chemotaxis] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070098[chemokine-mediated signaling pathway] GO:0090026[positive regulation of monocyte chemotaxis] GO:0090280[positive regulation of calcium ion import] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1903237[negative regulation of leukocyte tethering or rolling] GO:1990869[cellular response to chemokine] GO:2000406[positive regulation of T cell migration] GO:2000669[negative regulation of dendritic cell apoptotic process]
The Human Protein Atlas project is funded
