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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q22.2
Chromosome location (bp)
73436433 - 73496024
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals 1,2,3,4. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis 5,6. Dephosphorylates and activates transcription factor NFATC1 7. Dephosphorylates and inactivates transcription factor ELK1 8. Dephosphorylates DARPP32 9. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding, Hydrolase, Protein phosphatase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001913[T cell mediated cytotoxicity] GO:0001915[negative regulation of T cell mediated cytotoxicity] GO:0001946[lymphangiogenesis] GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004723[calcium-dependent protein serine/threonine phosphatase activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005955[calcineurin complex] GO:0006468[protein phosphorylation] GO:0006470[protein dephosphorylation] GO:0007165[signal transduction] GO:0007507[heart development] GO:0007612[learning] GO:0007613[memory] GO:0008287[protein serine/threonine phosphatase complex] GO:0010468[regulation of gene expression] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0017156[calcium-ion regulated exocytosis] GO:0019899[enzyme binding] GO:0023057[negative regulation of signaling] GO:0030018[Z disc] GO:0030217[T cell differentiation] GO:0030315[T-tubule] GO:0030346[protein phosphatase 2B binding] GO:0031987[locomotion involved in locomotory behavior] GO:0032991[protein-containing complex] GO:0033173[calcineurin-NFAT signaling cascade] GO:0033192[calmodulin-dependent protein phosphatase activity] GO:0034097[response to cytokine] GO:0035774[positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042098[T cell proliferation] GO:0042110[T cell activation] GO:0043029[T cell homeostasis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048675[axon extension] GO:0048741[skeletal muscle fiber development] GO:0050796[regulation of insulin secretion] GO:0051049[regulation of transport] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097720[calcineurin-mediated signaling] GO:0098978[glutamatergic synapse] GO:1900242[regulation of synaptic vesicle endocytosis] GO:1901386[negative regulation of voltage-gated calcium channel activity] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905949[negative regulation of calcium ion import across plasma membrane]
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004723[calcium-dependent protein serine/threonine phosphatase activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005955[calcineurin complex] GO:0006468[protein phosphorylation] GO:0006470[protein dephosphorylation] GO:0007165[signal transduction] GO:0007612[learning] GO:0007613[memory] GO:0008287[protein serine/threonine phosphatase complex] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0017156[calcium-ion regulated exocytosis] GO:0019899[enzyme binding] GO:0023057[negative regulation of signaling] GO:0030346[protein phosphatase 2B binding] GO:0032991[protein-containing complex] GO:0033173[calcineurin-NFAT signaling cascade] GO:0033192[calmodulin-dependent protein phosphatase activity] GO:0035774[positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042098[T cell proliferation] GO:0042110[T cell activation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048675[axon extension] GO:0048741[skeletal muscle fiber development] GO:0050796[regulation of insulin secretion] GO:0051049[regulation of transport] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097720[calcineurin-mediated signaling] GO:1901386[negative regulation of voltage-gated calcium channel activity] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905949[negative regulation of calcium ion import across plasma membrane]
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721[phosphoprotein phosphatase activity] GO:0004722[protein serine/threonine phosphatase activity] GO:0004723[calcium-dependent protein serine/threonine phosphatase activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005955[calcineurin complex] GO:0006468[protein phosphorylation] GO:0006470[protein dephosphorylation] GO:0007165[signal transduction] GO:0007612[learning] GO:0007613[memory] GO:0008287[protein serine/threonine phosphatase complex] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0017018[myosin phosphatase activity] GO:0017156[calcium-ion regulated exocytosis] GO:0019899[enzyme binding] GO:0023057[negative regulation of signaling] GO:0030346[protein phosphatase 2B binding] GO:0032991[protein-containing complex] GO:0033173[calcineurin-NFAT signaling cascade] GO:0033192[calmodulin-dependent protein phosphatase activity] GO:0035774[positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042098[T cell proliferation] GO:0042110[T cell activation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0046983[protein dimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0048675[axon extension] GO:0048741[skeletal muscle fiber development] GO:0050796[regulation of insulin secretion] GO:0051049[regulation of transport] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0097720[calcineurin-mediated signaling] GO:1901386[negative regulation of voltage-gated calcium channel activity] GO:1901387[positive regulation of voltage-gated calcium channel activity] GO:1905665[positive regulation of calcium ion import across plasma membrane] GO:1905949[negative regulation of calcium ion import across plasma membrane]
The Human Protein Atlas project is funded
