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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Golgi brefeldin A resistant guanine nucleotide exchange factor 1
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.32
Chromosome location (bp)
102245371 - 102382899
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) 1,2,3,4,5,6,7. Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adapter protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) 8. Has GEF activity towards ARF1 9. Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP 10. Required for the assembly of the Golgi apparatus 11,12. The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions 13,14. May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate 15,16. In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex 17. Plays a role in maintaining mitochondrial morphology 18....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Protein transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lipid-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005794[Golgi apparatus] GO:0015031[protein transport] GO:0032012[regulation of ARF protein signal transduction]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005794[Golgi apparatus] GO:0015031[protein transport] GO:0032012[regulation of ARF protein signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0002263[cell activation involved in immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005737[cytoplasm] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005794[Golgi apparatus] GO:0005801[cis-Golgi network] GO:0005802[trans-Golgi network] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0006888[endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0006892[post-Golgi vesicle-mediated transport] GO:0006895[Golgi to endosome transport] GO:0007030[Golgi organization] GO:0007346[regulation of mitotic cell cycle] GO:0008289[lipid binding] GO:0015031[protein transport] GO:0016020[membrane] GO:0030593[neutrophil chemotaxis] GO:0031252[cell leading edge] GO:0032012[regulation of ARF protein signal transduction] GO:0034067[protein localization to Golgi apparatus] GO:0042147[retrograde transport, endosome to Golgi] GO:0048205[COPI coating of Golgi vesicle] GO:0060271[cilium assembly] GO:0061162[establishment of monopolar cell polarity] GO:0070973[protein localization to endoplasmic reticulum exit site] GO:0080025[phosphatidylinositol-3,5-bisphosphate binding] GO:0090166[Golgi disassembly] GO:0097111[endoplasmic reticulum-Golgi intermediate compartment organization] GO:0098586[cellular response to virus] GO:1903409[reactive oxygen species biosynthetic process] GO:1903420[protein localization to endoplasmic reticulum tubular network] GO:2000008[regulation of protein localization to cell surface]
Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0002263[cell activation involved in immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005737[cytoplasm] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005794[Golgi apparatus] GO:0005801[cis-Golgi network] GO:0005802[trans-Golgi network] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0006888[endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0006892[post-Golgi vesicle-mediated transport] GO:0006895[Golgi to endosome transport] GO:0007030[Golgi organization] GO:0007346[regulation of mitotic cell cycle] GO:0008289[lipid binding] GO:0015031[protein transport] GO:0016020[membrane] GO:0030593[neutrophil chemotaxis] GO:0031252[cell leading edge] GO:0032012[regulation of ARF protein signal transduction] GO:0034067[protein localization to Golgi apparatus] GO:0042147[retrograde transport, endosome to Golgi] GO:0048205[COPI coating of Golgi vesicle] GO:0060271[cilium assembly] GO:0061162[establishment of monopolar cell polarity] GO:0070973[protein localization to endoplasmic reticulum exit site] GO:0080025[phosphatidylinositol-3,5-bisphosphate binding] GO:0090166[Golgi disassembly] GO:0097111[endoplasmic reticulum-Golgi intermediate compartment organization] GO:0098586[cellular response to virus] GO:1903409[reactive oxygen species biosynthetic process] GO:1903420[protein localization to endoplasmic reticulum tubular network] GO:2000008[regulation of protein localization to cell surface]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0002263[cell activation involved in immune response] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005737[cytoplasm] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005794[Golgi apparatus] GO:0005801[cis-Golgi network] GO:0005802[trans-Golgi network] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0006888[endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0006892[post-Golgi vesicle-mediated transport] GO:0006895[Golgi to endosome transport] GO:0007030[Golgi organization] GO:0007346[regulation of mitotic cell cycle] GO:0008289[lipid binding] GO:0015031[protein transport] GO:0016020[membrane] GO:0030593[neutrophil chemotaxis] GO:0031252[cell leading edge] GO:0032012[regulation of ARF protein signal transduction] GO:0034067[protein localization to Golgi apparatus] GO:0042147[retrograde transport, endosome to Golgi] GO:0048205[COPI coating of Golgi vesicle] GO:0060271[cilium assembly] GO:0061162[establishment of monopolar cell polarity] GO:0070973[protein localization to endoplasmic reticulum exit site] GO:0080025[phosphatidylinositol-3,5-bisphosphate binding] GO:0090166[Golgi disassembly] GO:0097111[endoplasmic reticulum-Golgi intermediate compartment organization] GO:0098586[cellular response to virus] GO:1903409[reactive oxygen species biosynthetic process] GO:1903420[protein localization to endoplasmic reticulum tubular network] GO:2000008[regulation of protein localization to cell surface]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005794[Golgi apparatus] GO:0015031[protein transport] GO:0032012[regulation of ARF protein signal transduction]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005794[Golgi apparatus] GO:0015031[protein transport] GO:0032012[regulation of ARF protein signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0032012[regulation of ARF protein signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0032012[regulation of ARF protein signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0032012[regulation of ARF protein signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0032012[regulation of ARF protein signal transduction]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005794[Golgi apparatus] GO:0032012[regulation of ARF protein signal transduction]
Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0032012[regulation of ARF protein signal transduction]
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0032012[regulation of ARF protein signal transduction]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005794[Golgi apparatus] GO:0015031[protein transport] GO:0032012[regulation of ARF protein signal transduction]
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