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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q22
Chromosome location (bp)
58982638 - 59106921
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin-protein ligase required to prevent centriole reduplication 1,2. Probably acts by ubiquitinating positive regulators of centriole reduplication 3. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes 4. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome 5. Has anti-HIV activity 6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Repressor, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005777[peroxisome] GO:0005778[peroxisomal membrane] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0016235[aggresome] GO:0016558[protein import into peroxisome matrix] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031625[ubiquitin protein ligase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0035098[ESC/E(Z) complex] GO:0035518[histone H2A monoubiquitination] GO:0036353[histone H2A-K119 monoubiquitination] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045893[positive regulation of DNA-templated transcription] GO:0046600[negative regulation of centriole replication] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0070842[aggresome assembly]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005777[peroxisome] GO:0005778[peroxisomal membrane] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0016235[aggresome] GO:0016558[protein import into peroxisome matrix] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031625[ubiquitin protein ligase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0035098[ESC/E(Z) complex] GO:0035518[histone H2A monoubiquitination] GO:0036353[histone H2A-K119 monoubiquitination] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045893[positive regulation of DNA-templated transcription] GO:0046600[negative regulation of centriole replication] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0070842[aggresome assembly]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005777[peroxisome] GO:0005778[peroxisomal membrane] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0016020[membrane] GO:0016235[aggresome] GO:0016558[protein import into peroxisome matrix] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0031625[ubiquitin protein ligase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0035098[ESC/E(Z) complex] GO:0035518[histone H2A monoubiquitination] GO:0036353[histone H2A-K119 monoubiquitination] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0045893[positive regulation of DNA-templated transcription] GO:0046600[negative regulation of centriole replication] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0070842[aggresome assembly]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
